The Changing COVID-19 Landscape: A Feasibility Study to Capture Momentary Residential Environmental Exposures and Asthma Sypmtoms in Adults
不断变化的 COVID-19 形势:捕捉瞬时居住环境暴露和成人哮喘症状的可行性研究
基本信息
- 批准号:10250681
- 负责人:
- 金额:$ 25.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-15 至 2023-02-28
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAddressAdolescentAdultAdvocateAffectAirAir PollutantsAreaAsthmaBehaviorCOVID-19COVID-19 pandemicCOVID-19 preventionCellular PhoneChemical ExposureChemicalsChicagoChildChronicCommunicable DiseasesCommunitiesComplexComputer softwareCoronavirusDataData CollectionData ReportingDeath RateDiagnosisDirect CostsDisease OutbreaksDisinfectantsEcological momentary assessmentEconomic BurdenElderlyEnvironmental ExposureEnvironmental ImpactEnvironmental MonitoringEnvironmental Risk FactorExposure toFaceFacilities and Administrative CostsFeasibility StudiesFrequenciesFutureGoalsHandHomeHome environmentHourHouseholdHousingHygieneIndividualIndoor Air QualityIndoor environmentInterventionLung diseasesMeasuresMidwestern United StatesMonitorNotificationNursesParticipantParticulateParticulate MatterPatient Self-ReportPhysiciansPopulationPreventive measurePublic HealthPulmonary Function Test/Forced Expiratory Volume 1Quality-Adjusted Life YearsReadinessRecommendationReportingResearchRisk FactorsRisk ReductionScheduleScientistSelf ManagementShelter facilitySpirometrySurveysSymptomsTimeUnited StatesVirusVirus Diseasesage groupasthma exacerbationbasecostdesigneconomic impactenvironmental tobacco smokeexperiencefine particleshealth economicsimprovedinnovationmemberpandemic diseasepollutantpulmonary functionrecruitsensorusabilityvolatile organic compoundwillingness
项目摘要
ABSTRACT
The global pandemic of coronavirus 2019 (COVID-19) is a substantial cause for concern among individuals
with chronic respiratory diseases, including those with asthma. It is estimated that more than 60% of adults
with asthma have uncontrolled symptoms and this represents a substantial health and economic impact.
Compared to children, adults are nearly five times more likely to die from asthma and the asthma-related
death rate is highest among those 65 years and older. Viral infections are a prominent risk factor for
asthma exacerbation and, thus, SARS-CoV-2, the virus responsible for COVID-19, is cause for alarm among
those diagnosed with asthma. Sheltering-in-place orders and recommendations, physical distancing, wearing
face coverings, hand hygiene, and increased cleaning and disinfecting are primary COVID-19 preventative
measures advocated. The effects of home-based strategies to prevent COVID-19, specifically increased
residential exposure to cleaning/disinfecting agents and particulates on adults with asthma is unknown. Our
long term goal is to characterize the impact of COVID-19 on existing asthma risk factors so as to develop
tailored, home-based asthma interventions that adequately acknowledge COVID-19 and are responsive to the
changing home environment and home routines resulting from this pandemic. The aims of this study are: 1)
determine the feasibility and usability of: (a) ecological momentary assessment (EMA) to assess self-report
residential environmental exposures and asthma symptoms, (b) home monitoring of objective environmental
exposures (total volatile organic compounds [VOCs], particulates [PM2.5]), and lung function (home spirometry);
2a) assess the frequency and degree of residential environmental exposures (e.g., disinfectants/cleaners,
second-hand smoke) via (a) self-reported data, and (b) home monitoring objective measures, 2b) assess the
level of asthma control as indicated by self-reported asthma symptoms and lung function; and 3) explore
associations of self-reported and objective measures of residential environmental exposures with self-reported
and objective measures of asthma control. We will recruit 50 adults with asthma who completed our ongoing
online COVID-19 and asthma survey, indicated willingness to be contacted for future studies, reported high
use of disinfectant/cleaning products, and have not-well controlled asthma. Participants will receive an indoor
air quality monitor and a home spirometer to measure VOCs, PM2.5, and FEV1% respectively. EMA will be
collected using a personal smartphone and EMA software platform. Participants’ will be sent scheduled and
random EMA notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation
strategies. After the 14-day data collection period, participants will respond to survey items related
acceptability, appropriateness, and feasibility. Findings from this feasibility study will support a powered study
to address the impact of environmental exposures related to COVID-19 and to enhance preparedness for
future infectious disease outbreaks by developing innovative intervention strategies for those with asthma.
摘要
2019年冠状病毒的全球大流行(新冠肺炎)引起个人的极大关注
患有慢性呼吸道疾病,包括哮喘患者。据估计,超过60%的成年人
患有哮喘的人有无法控制的症状,这对健康和经济都有重大影响。
与儿童相比,成年人死于哮喘和哮喘相关疾病的可能性几乎是儿童的五倍
65岁及以上人群的死亡率最高。病毒感染是一个突出的风险因素
哮喘的加剧,以及导致新冠肺炎的SARS-CoV-2病毒,是引起
那些被诊断为哮喘的人。就地避难命令和建议,物理距离,佩戴
面罩、手部卫生以及增加清洁和消毒是新冠肺炎的主要预防措施
提倡的措施。预防新冠肺炎的居家战略的效果,特别是增加了
成人哮喘患者在住宅中接触清洁/消毒剂和微粒的情况尚不清楚。我们的
长期目标是表征新冠肺炎对现有哮喘危险因素的影响,从而发展
量身定做的、基于家庭的哮喘干预措施,充分承认新冠肺炎并对
这场大流行导致的家庭环境和家庭惯例的变化。本研究的目的是:1)
确定:(A)评估自我报告的生态瞬时评估(EMA)的可行性和可用性
住宅环境暴露和哮喘症状,(B)客观环境的家庭监测
暴露(总挥发性有机化合物[VOCs]、颗粒物[PM2.5])和肺功能(家庭肺活量测定);
2a)评估住宅环境暴露的频率和程度(例如消毒剂/清洁剂、
二手烟)通过(A)自我报告的数据,和(B)家庭监测客观措施,2b)评估
通过自我报告的哮喘症状和肺功能来指示哮喘控制水平;以及3)探索
居住环境暴露的自报和客观测量与自报的关系
以及控制哮喘的客观措施。我们将招募50名哮喘成人,他们完成了我们正在进行的
在线新冠肺炎和哮喘调查显示,愿意被联系进行未来研究,报告说很高
使用消毒剂/清洁用品,并未很好地控制哮喘。参赛者将获得室内
空气质量监测仪和家庭呼吸仪分别测量VOCs、PM2.5和FEV1%。EMA将是
使用个人智能手机和EMA软件平台收集的数据。参与者将按计划发送,并
随机EMA通知以评估哮喘症状、环境暴露、肺功能和缓解
战略。在14天的数据收集期后,参与者将回答相关的调查项目
可接受性、适当性和可行性。这项可行性研究的结果将支持动力研究。
应对与新冠肺炎有关的环境暴露的影响,并加强准备工作
通过为哮喘患者开发创新的干预策略来应对未来的传染病暴发。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kamal M Eldeirawi其他文献
Kamal M Eldeirawi的其他文献
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{{ truncateString('Kamal M Eldeirawi', 18)}}的其他基金
The Changing COVID-19 Landscape: A Feasibility Study to Capture Momentary Residential Environmental Exposures and Asthma Sypmtoms in Adults
不断变化的 COVID-19 形势:捕捉瞬时居住环境暴露和成人哮喘症状的可行性研究
- 批准号:
10369705 - 财政年份:2021
- 资助金额:
$ 25.71万 - 项目类别:
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