The Changing COVID-19 Landscape: A Feasibility Study to Capture Momentary Residential Environmental Exposures and Asthma Sypmtoms in Adults
不断变化的 COVID-19 形势:捕捉瞬时居住环境暴露和成人哮喘症状的可行性研究
基本信息
- 批准号:10369705
- 负责人:
- 金额:$ 21.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-15 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAddressAdolescentAdultAdvocateAffectAirAir PollutantsAreaAsthmaBehaviorCOVID-19COVID-19 impactCOVID-19 pandemicCOVID-19 preventionCellular PhoneChemical ExposureChemicalsChicagoChildCommunicable DiseasesCommunitiesComplexComputer softwareDataData CollectionData ReportingDeath RateDiagnosisDirect CostsDisease OutbreaksDisinfectantsEcological momentary assessmentEconomic BurdenElderlyEnvironmental ExposureEnvironmental ImpactEnvironmental MonitoringEnvironmental Risk FactorExposure toFaceFacilities and Administrative CostsFeasibility StudiesFrequenciesFutureGoalsHandHomeHome environmentHourHouseholdHousingHygieneIndividualIndoor Air QualityIndoor environmentInterventionMeasuresMidwestern United StatesMonitorNotificationNursesParticipantParticulateParticulate MatterPatient Self-ReportPhysiciansPopulationPreventive measurePublic HealthPulmonary Function Test/Forced Expiratory Volume 1Quality-Adjusted Life YearsReadinessRecommendationReportingResearchRespiratory DiseaseRisk FactorsRisk ReductionScheduleScientistSelf ManagementShelter facilitySpirometrySurveysSymptomsTimeUnited StatesVirusVirus Diseasesage groupasthma exacerbationbasechronic respiratory diseasecostdesigneconomic impactenvironmental tobacco smokeexperiencefine particleshealth economicsimprovedinnovationmemberpandemic coronaviruspandemic diseasepollutantpulmonary functionrecruitsensorusabilityvolatile organic compoundwillingness
项目摘要
ABSTRACT
The global pandemic of coronavirus 2019 (COVID-19) is a substantial cause for concern among individuals
with chronic respiratory diseases, including those with asthma. It is estimated that more than 60% of adults
with asthma have uncontrolled symptoms and this represents a substantial health and economic impact.
Compared to children, adults are nearly five times more likely to die from asthma and the asthma-related
death rate is highest among those 65 years and older. Viral infections are a prominent risk factor for
asthma exacerbation and, thus, SARS-CoV-2, the virus responsible for COVID-19, is cause for alarm among
those diagnosed with asthma. Sheltering-in-place orders and recommendations, physical distancing, wearing
face coverings, hand hygiene, and increased cleaning and disinfecting are primary COVID-19 preventative
measures advocated. The effects of home-based strategies to prevent COVID-19, specifically increased
residential exposure to cleaning/disinfecting agents and particulates on adults with asthma is unknown. Our
long term goal is to characterize the impact of COVID-19 on existing asthma risk factors so as to develop
tailored, home-based asthma interventions that adequately acknowledge COVID-19 and are responsive to the
changing home environment and home routines resulting from this pandemic. The aims of this study are: 1)
determine the feasibility and usability of: (a) ecological momentary assessment (EMA) to assess self-report
residential environmental exposures and asthma symptoms, (b) home monitoring of objective environmental
exposures (total volatile organic compounds [VOCs], particulates [PM2.5]), and lung function (home spirometry);
2a) assess the frequency and degree of residential environmental exposures (e.g., disinfectants/cleaners,
second-hand smoke) via (a) self-reported data, and (b) home monitoring objective measures, 2b) assess the
level of asthma control as indicated by self-reported asthma symptoms and lung function; and 3) explore
associations of self-reported and objective measures of residential environmental exposures with self-reported
and objective measures of asthma control. We will recruit 50 adults with asthma who completed our ongoing
online COVID-19 and asthma survey, indicated willingness to be contacted for future studies, reported high
use of disinfectant/cleaning products, and have not-well controlled asthma. Participants will receive an indoor
air quality monitor and a home spirometer to measure VOCs, PM2.5, and FEV1% respectively. EMA will be
collected using a personal smartphone and EMA software platform. Participants’ will be sent scheduled and
random EMA notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation
strategies. After the 14-day data collection period, participants will respond to survey items related
acceptability, appropriateness, and feasibility. Findings from this feasibility study will support a powered study
to address the impact of environmental exposures related to COVID-19 and to enhance preparedness for
future infectious disease outbreaks by developing innovative intervention strategies for those with asthma.
摘要
2019年冠状病毒(COVID-19)全球大流行是个人担忧的重大原因
慢性呼吸道疾病,包括哮喘。据估计,超过60%的成年人
哮喘患者的症状不受控制,这对健康和经济造成了重大影响。
与儿童相比,成年人死于哮喘和哮喘相关疾病的可能性高出近五倍。
65岁及以上的人死亡率最高。病毒感染是一个突出的危险因素,
哮喘恶化,因此,SARS-CoV-2,导致COVID-19的病毒,是引起人们恐慌的原因。
被诊断为哮喘的人。就地庇护命令和建议、身体距离、穿戴
面部覆盖物、手部卫生以及加强清洁和消毒是COVID-19的主要预防措施
提倡的措施。家庭预防COVID-19策略的效果特别增加
成人哮喘患者的住宅暴露于清洁/消毒剂和颗粒物的情况尚不清楚。我们
长期目标是描述COVID-19对现有哮喘风险因素的影响,
量身定制的、以家庭为基础的哮喘干预措施,充分认识到COVID-19,并对
改变家居环境及日常生活。本研究的目的是:1)
确定可行性和可用性:(a)生态瞬时评估(EMA),以评估自我报告
住宅环境暴露和哮喘症状,(B)客观环境的家庭监测
暴露(总挥发性有机化合物[VOC]、颗粒物[PM2.5])和肺功能(家庭肺量计);
2a)评估住宅环境暴露的频率和程度(例如,消毒剂/清洁剂,
二手烟)通过(a)自我报告的数据,和(B)家庭监测客观措施,2 B)评估
哮喘控制水平,如自我报告的哮喘症状和肺功能所示;以及3)探索
居民环境暴露的自我报告和客观测量与自我报告的
和哮喘控制的客观措施。我们将招募50名成年哮喘患者,
在线COVID-19和哮喘调查,表示愿意为未来的研究联系,报告高
使用消毒剂/清洁产品,哮喘控制不佳。参与者将获得一个室内
空气质量监测仪和家用肺活量计分别测量VOCs、PM2.5和FEV1%。EMA将
使用个人智能手机和EMA软件平台收集。参加者的申请将按计划发送,
随机EMA通知,以评估哮喘症状、环境暴露、肺功能和缓解措施
战略布局在14天的数据收集期后,参与者将回答与
可接受性、适当性和可行性。本可行性研究的结果将支持一项有把握度的研究
应对与COVID-19相关的环境暴露的影响,并加强防范
通过为哮喘患者制定创新的干预策略来预防未来的传染病爆发。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kamal M Eldeirawi其他文献
Kamal M Eldeirawi的其他文献
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{{ truncateString('Kamal M Eldeirawi', 18)}}的其他基金
The Changing COVID-19 Landscape: A Feasibility Study to Capture Momentary Residential Environmental Exposures and Asthma Sypmtoms in Adults
不断变化的 COVID-19 形势:捕捉瞬时居住环境暴露和成人哮喘症状的可行性研究
- 批准号:
10250681 - 财政年份:2021
- 资助金额:
$ 21.97万 - 项目类别:
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