The Changing COVID-19 Landscape: A Feasibility Study to Capture Momentary Residential Environmental Exposures and Asthma Sypmtoms in Adults
不断变化的 COVID-19 形势:捕捉瞬时居住环境暴露和成人哮喘症状的可行性研究
基本信息
- 批准号:10369705
- 负责人:
- 金额:$ 21.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-15 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAddressAdolescentAdultAdvocateAffectAirAir PollutantsAreaAsthmaBehaviorCOVID-19COVID-19 impactCOVID-19 pandemicCOVID-19 preventionCellular PhoneChemical ExposureChemicalsChicagoChildCommunicable DiseasesCommunitiesComplexComputer softwareDataData CollectionData ReportingDeath RateDiagnosisDirect CostsDisease OutbreaksDisinfectantsEcological momentary assessmentEconomic BurdenElderlyEnvironmental ExposureEnvironmental ImpactEnvironmental MonitoringEnvironmental Risk FactorExposure toFaceFacilities and Administrative CostsFeasibility StudiesFrequenciesFutureGoalsHandHomeHome environmentHourHouseholdHousingHygieneIndividualIndoor Air QualityIndoor environmentInterventionMeasuresMidwestern United StatesMonitorNotificationNursesParticipantParticulateParticulate MatterPatient Self-ReportPhysiciansPopulationPreventive measurePublic HealthPulmonary Function Test/Forced Expiratory Volume 1Quality-Adjusted Life YearsReadinessRecommendationReportingResearchRespiratory DiseaseRisk FactorsRisk ReductionScheduleScientistSelf ManagementShelter facilitySpirometrySurveysSymptomsTimeUnited StatesVirusVirus Diseasesage groupasthma exacerbationbasechronic respiratory diseasecostdesigneconomic impactenvironmental tobacco smokeexperiencefine particleshealth economicsimprovedinnovationmemberpandemic coronaviruspandemic diseasepollutantpulmonary functionrecruitsensorusabilityvolatile organic compoundwillingness
项目摘要
ABSTRACT
The global pandemic of coronavirus 2019 (COVID-19) is a substantial cause for concern among individuals
with chronic respiratory diseases, including those with asthma. It is estimated that more than 60% of adults
with asthma have uncontrolled symptoms and this represents a substantial health and economic impact.
Compared to children, adults are nearly five times more likely to die from asthma and the asthma-related
death rate is highest among those 65 years and older. Viral infections are a prominent risk factor for
asthma exacerbation and, thus, SARS-CoV-2, the virus responsible for COVID-19, is cause for alarm among
those diagnosed with asthma. Sheltering-in-place orders and recommendations, physical distancing, wearing
face coverings, hand hygiene, and increased cleaning and disinfecting are primary COVID-19 preventative
measures advocated. The effects of home-based strategies to prevent COVID-19, specifically increased
residential exposure to cleaning/disinfecting agents and particulates on adults with asthma is unknown. Our
long term goal is to characterize the impact of COVID-19 on existing asthma risk factors so as to develop
tailored, home-based asthma interventions that adequately acknowledge COVID-19 and are responsive to the
changing home environment and home routines resulting from this pandemic. The aims of this study are: 1)
determine the feasibility and usability of: (a) ecological momentary assessment (EMA) to assess self-report
residential environmental exposures and asthma symptoms, (b) home monitoring of objective environmental
exposures (total volatile organic compounds [VOCs], particulates [PM2.5]), and lung function (home spirometry);
2a) assess the frequency and degree of residential environmental exposures (e.g., disinfectants/cleaners,
second-hand smoke) via (a) self-reported data, and (b) home monitoring objective measures, 2b) assess the
level of asthma control as indicated by self-reported asthma symptoms and lung function; and 3) explore
associations of self-reported and objective measures of residential environmental exposures with self-reported
and objective measures of asthma control. We will recruit 50 adults with asthma who completed our ongoing
online COVID-19 and asthma survey, indicated willingness to be contacted for future studies, reported high
use of disinfectant/cleaning products, and have not-well controlled asthma. Participants will receive an indoor
air quality monitor and a home spirometer to measure VOCs, PM2.5, and FEV1% respectively. EMA will be
collected using a personal smartphone and EMA software platform. Participants’ will be sent scheduled and
random EMA notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation
strategies. After the 14-day data collection period, participants will respond to survey items related
acceptability, appropriateness, and feasibility. Findings from this feasibility study will support a powered study
to address the impact of environmental exposures related to COVID-19 and to enhance preparedness for
future infectious disease outbreaks by developing innovative intervention strategies for those with asthma.
摘要
2019年冠状病毒的全球大流行(新冠肺炎)引起个人的极大关注
患有慢性呼吸道疾病,包括哮喘患者。据估计,超过60%的成年人
患有哮喘的人有无法控制的症状,这对健康和经济都有重大影响。
与儿童相比,成年人死于哮喘和哮喘相关疾病的可能性几乎是儿童的五倍
65岁及以上人群的死亡率最高。病毒感染是一个突出的风险因素
哮喘的加剧,以及导致新冠肺炎的SARS-CoV-2病毒,是引起
那些被诊断为哮喘的人。就地避难命令和建议,物理距离,佩戴
面罩、手部卫生以及增加清洁和消毒是新冠肺炎的主要预防措施
提倡的措施。预防新冠肺炎的居家战略的效果,特别是增加了
成人哮喘患者在住宅中接触清洁/消毒剂和微粒的情况尚不清楚。我们的
长期目标是表征新冠肺炎对现有哮喘危险因素的影响,从而发展
量身定做的、基于家庭的哮喘干预措施,充分承认新冠肺炎并对
这场大流行导致的家庭环境和家庭惯例的变化。本研究的目的是:1)
确定:(A)评估自我报告的生态瞬时评估(EMA)的可行性和可用性
住宅环境暴露和哮喘症状,(B)客观环境的家庭监测
暴露(总挥发性有机化合物[VOCs]、颗粒物[PM2.5])和肺功能(家庭肺活量测定);
2a)评估住宅环境暴露的频率和程度(例如消毒剂/清洁剂、
二手烟)通过(A)自我报告的数据,和(B)家庭监测客观措施,2b)评估
通过自我报告的哮喘症状和肺功能来指示哮喘控制水平;以及3)探索
居住环境暴露的自报和客观测量与自报的关系
以及控制哮喘的客观措施。我们将招募50名哮喘成人,他们完成了我们正在进行的
在线新冠肺炎和哮喘调查显示,愿意被联系进行未来研究,报告说很高
使用消毒剂/清洁用品,并未很好地控制哮喘。参赛者将获得室内
空气质量监测仪和家庭呼吸仪分别测量VOCs、PM2.5和FEV1%。EMA将是
使用个人智能手机和EMA软件平台收集的数据。参与者将按计划发送,并
随机EMA通知以评估哮喘症状、环境暴露、肺功能和缓解
战略。在14天的数据收集期后,参与者将回答相关的调查项目
可接受性、适当性和可行性。这项可行性研究的结果将支持动力研究。
应对与新冠肺炎有关的环境暴露的影响,并加强准备工作
通过为哮喘患者开发创新的干预策略来应对未来的传染病暴发。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Kamal M Eldeirawi其他文献
Kamal M Eldeirawi的其他文献
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{{ truncateString('Kamal M Eldeirawi', 18)}}的其他基金
The Changing COVID-19 Landscape: A Feasibility Study to Capture Momentary Residential Environmental Exposures and Asthma Sypmtoms in Adults
不断变化的 COVID-19 形势:捕捉瞬时居住环境暴露和成人哮喘症状的可行性研究
- 批准号:
10250681 - 财政年份:2021
- 资助金额:
$ 21.97万 - 项目类别:
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