Project 2-Understanding CIN2+ among HIV infected women after LEEP: An epidemiological and immunohistochemical study
项目 2 - 了解 LEEP 后 HIV 感染女性中的 CIN2:流行病学和免疫组织化学研究
基本信息
- 批准号:10256043
- 负责人:
- 金额:$ 12.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-07 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS/HIV problemAcetic AcidsAddressAdoptedAfricaAge-YearsAppearanceBackBiopsyCancer EtiologyCervicalCervical Intraepithelial NeoplasiaCervix UteriCessation of lifeCharacteristicsCold TherapyColposcopyCountryDevelopmentDiagnosisDiseaseEnrollmentEpidemiologyExcisionGeneral PopulationHIVHIV SeropositivityHPV-High RiskHigh PrevalenceHistocompatibility TestingHuman PapillomavirusHuman papilloma virus infectionHuman papillomavirus 16ImmuneIncidenceIntercellular JunctionsInternational Agency for Research on CancerKenyaLesionMalignant NeoplasmsMalignant neoplasm of cervix uteriNatural HistoryRecommendationRecurrenceResourcesRiskRisk FactorsScienceSpecimenTissuesUgandaVisitVisualWomanbasecancer invasivenesshealinghigh riskloop electrosurgical excision procedurenovel strategiespreventscreeningstandard of care
项目摘要
Abstract
Current estimates indicate that every year 5,250 women (crude rate 20.5) are diagnosed with cervical cancer in
Kenya and 3,286 (crude rate 12.8) die from the disease. Cervical cancer ranks as the 2nd most frequent cancer
among women in Kenya and the 1st most frequent cancer among women between 15-44 years of age. About
9.1% of women in the general population are estimated to harbor human papillomavirus (HPV) 16/18 and 63.1%
of invasive cervical cancers are attributed to HPV 16/18. In Uganda, cervical cancer is the number one cause of
cancer related death in women. 6,413 Ugandan women (crude rate 28.8) are diagnosed with cervical cancer
and 4,301(crude rate 19.3) die from the disease. About 3.6% of the general population harbor HPV 16/18 and
57% of invasive cancer is attributable to HPV 16/18. HIV-infected women have higher prevalence, incidence,
and persistence of HPV infections, more so in women with severe immune compromise. HIV has been shown
to increase the risk of the development, progression and recurrence of cervical intraepithelial neoplasia. Several
studies have consistently shown that HIV-infected women present higher risk of CIN persistence or recurrence
after standard therapy . Both Kenya and Uganda have high prevalence for HIV/AIDS at 7% and 12.9%,
respectively. In settings where loop electrosurgical excision procedure (LEEP) is available, accessible and
appropriate, treatment with LEEP is recommended by the WHO. However, there is a paucity of studies assessing
the efficacy of LEEP among HIV-infected women and the characteristics of CIN2/3 lesions after LEEP. The core
objective of this application is to understand the natural history of recurrent CIN2/3 lesions among HIV-infected
women after LEEP. To help guide management based on HIV/HPV science, we propose an epidemiologic and
immunohistochemical study of the cervix following LEEP to address the value of destruction of the cervical
transformation zone to prevent cancer. We propose to enroll 300 HIV-infected women with CIN2/3 undergoing
LEEP and follow them every 6 months for 2 years with colposcopy and biopsy when appropriate. We will do a
repeat LEEP for recurrent CIN2/3 lesions.
The Specific Aims for this proposed study are:
1. To assess the incidence and risk factors for “recurrent” CIN2/3 after LEEP among HIV- infected women.
2. To determine baseline HR-HPV types (in tissue) among HIV-infected women with CIN2/3 undergoing LEEP
compared to the HR-HPV types with “recurrent” cervical lesions after a second LEEP.
3. To determine the immunohistochemical differences between the initial and repeat LEEP specimens among
HIV-infected women with “recurrent” CIN2/3
摘要
项目成果
期刊论文数量(0)
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{{ truncateString('SUSAN CU-UVIN', 18)}}的其他基金
Project 2-Understanding CIN2+ among HIV infected women after LEEP: An epidemiological and immunohistochemical study
项目 2 - 了解 LEEP 后 HIV 感染女性中的 CIN2:流行病学和免疫组织化学研究
- 批准号:
10084054 - 财政年份:2020
- 资助金额:
$ 12.8万 - 项目类别:
Project 2-Understanding CIN2+ among HIV infected women after LEEP: An epidemiological and immunohistochemical study
项目 2 - 了解 LEEP 后 HIV 感染女性中的 CIN2:流行病学和免疫组织化学研究
- 批准号:
10477369 - 财政年份:2020
- 资助金额:
$ 12.8万 - 项目类别:
Brown/Moi Training Program for the Prevention of HIV related Cervical Cancer
Brown/Moi 预防艾滋病毒相关宫颈癌培训计划
- 批准号:
9769364 - 财政年份:2019
- 资助金额:
$ 12.8万 - 项目类别:
Brown/Moi Training Program for the Prevention of HIV related Cervical Cancer
Brown/Moi 预防艾滋病毒相关宫颈癌培训计划
- 批准号:
10592421 - 财政年份:2019
- 资助金额:
$ 12.8万 - 项目类别:
Brown/Moi Training Program for the Prevention of HIV related Cervical Cancer
Brown/Moi 预防艾滋病毒相关宫颈癌培训计划
- 批准号:
10254449 - 财政年份:2019
- 资助金额:
$ 12.8万 - 项目类别:
Brown/Moi Training Program for the Prevention of HIV related Cervical Cancer
Brown/Moi 预防艾滋病毒相关宫颈癌培训计划
- 批准号:
9916830 - 财政年份:2019
- 资助金额:
$ 12.8万 - 项目类别:
Brown/Moi Training Program for the Prevention of HIV related Cervical Cancer
Brown/Moi 预防艾滋病毒相关宫颈癌培训计划
- 批准号:
10380119 - 财政年份:2019
- 资助金额:
$ 12.8万 - 项目类别:
Brown University and University of the Philippines Training Program for the Prevention of HIV in Vulnerable Populations
布朗大学和菲律宾大学针对弱势群体预防艾滋病毒培训计划
- 批准号:
10153917 - 财政年份:2017
- 资助金额:
$ 12.8万 - 项目类别:
Reproductive Hormones and their impact on HIV-1 acquisition
生殖激素及其对 HIV-1 获得的影响
- 批准号:
8319054 - 财政年份:2012
- 资助金额:
$ 12.8万 - 项目类别:
Reproductive Hormones and their impact on HIV-1 acquisition
生殖激素及其对 HIV-1 获得的影响
- 批准号:
8457131 - 财政年份:2012
- 资助金额:
$ 12.8万 - 项目类别:
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