The Arizona Department of Health Services Food Safety and Food Defense Project

亚利桑那州卫生服务部LFFM资助申请项目1-7摘要 亚利桑那州卫生服务实验室(ASPHL)拥有化学、 微生物学和放射学测试，以分析食品中的类似污染 防备和监管水平。ASPHL是符合国际标准化组织17025标准的蕨类实验室 对食品防御性分析物的分析进行认证，并寻求在#年保持这种能力 化学和微生物学科，以及扩展到放射化学分析 在为期5年的项目时间表内。(化学/微/RAD区域1)。 ASPHL是测试人造人类食品的主要服务实验室 亚利桑那州，并寻求引入金属和化学食品安全测试 州和县合作伙伴在人工食品项下采集的样品中的过敏原 监管计划标准(MFRPS)指南。(化学区域2)。 ASPHL与翻译基因组研究实验室(TGen)合作进行 400株沙门氏菌、大肠埃希氏菌、弯曲杆菌和李斯特氏菌的年度测序 并将继续作为FDA的GenomeTrakr的创始成员。 亚接受者TGen已经确定了1000多个目标微生物分离株，以考虑用于 对人类食物进行全基因组测序。(微道4)。 方法开发是ASPHL的强项，化学实验室建议 继续本练习，开发和验证合规性级别过敏原测试 将MAGPIX系统与XPonent 4.2软件配合使用，最终产品为书面版本 提交FDA非营利组织审查的分析方法。(化学区域4)。 ASPHL蕨类化学在使用电感耦合等离子体质谱和LC-电感耦合等离子体质谱仪进行金属分析方面能力很强 建议对元素分析手工法进行多实验室验证 EAM 4.12：电感耦合等离子体质谱分析瓶装水该方法将在两个不同的电感耦合等离子体中进行验证。 MS平台：安捷伦7700电感耦合等离子体质谱仪与安捷伦1200超高效液相色谱系统和 安捷伦8900电感耦合等离子体-三重四重质谱仪和安捷伦1260 Infinity II(化学SP D3)。

Arizona Department of Health Services LFFM Grant Application Projects 1-7 Summary The Arizona Department of Health Services Laboratory (ASPHL) has capacity in Chemical, Microbiological, and Radiological testing to analyze food products for like contamination at both preparedness and regulatory levels. ASPHL is a FERN Laboratory under ISO 17025 accreditation for the analysis of food defense analytes and seeks to maintain that capability in both chemical and microbiological disciplines as well as expanding into radiochemical analysis for the duration of the 5-year project timeline. (CHEM / MICRO / RAD Tract 1). The ASPHL is the primary servicing laboratory for the testing of manufactured human food for the State of Arizona and seeks to introduce chemical food safety testing for metals and allergens on samples collected by state and county partners under the Manufactured Food Regulatory Program Standards (MFRPS) guidelines. (CHEM Tract 2). The ASPHL is partnered with Translational Genomics Research Laboratory (TGEN) for the yearly sequencing of 400 isolates of Salmonella, E. coli, Campylobacter and Listeria monocytogenes and will continue as a founding member of the FDA’s GenomeTrakr. Subrecipient TGEN has identified greater than 1000 isolates of target organisms to consider for whole genome sequencing on human food. (MICRO Tract 4). Method development is a strength of the ASPHL and the Chemistry Laboratory proposes to continue this activity with the development and validation of compliance level Allergen Testing using the MagPix System with XPonent 4.2 software with the end product being a written analytical method to submit to the FDA NPO for review. (CHEM Tract 4). The ASPHL FERN Chemistry is strong on metals analysis using ICP-MS and LC-ICP-MS and proposes to engage in a multi-laboratory validation of the Elemental Analysis manual method EAM 4.12: Analysis of Bottled Water by ICP-MS. The method will be validated two different ICP- MS platforms: an Agilent 7700 ICP-MS coupled to an Agilent 1200 uHPLC system and an Agilent 8900 ICP-triple quadruple-MS coupled with an Agilent 1260 infinity II. (CHEM SP D3).