Preclinical development of capsid assembly modulators for the treatment of chronic hepatitis B virus infection

用于治疗慢性乙型肝炎病毒感染的衣壳组装调节剂的临床前开发

基本信息

  • 批准号:
    10257695
  • 负责人:
  • 金额:
    $ 100万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-05-24 至 2024-04-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Despite the availability of a safe and effective vaccine, there remains over 257 million people chronically infected with hepatitis B virus (HBV) world-wide. Individuals with chronic HBV infections are at risk for complications due to liver disease and liver cancer. Chronic HBV is currently managed with nucleos(t)ide reverse transcriptase inhibitors (NrtI) which partly suppress HBV DNA replication, normalize alanine aminotransferase levels (ALT) and slow disease progression. Front-line therapies, however, are not curative and patients with chronic HBV exhibit poor off-treatment responses requiring life-long therapy. New antivirals and immunomodulatory approaches are, therefore, needed to further suppress viral replication and provide the conditions that are required for immune control known as a “functional cure”. One of the most promising classes of compounds under investigation are the core protein allosteric modulators (CpAM) that block HBV replication at multiple stages of the viral life-cycle. Here, we report on a best-in-class CpAM that exhibits potent pan-genotypic antiviral activity. In this project, we propose to advance our lead CpAM into definitive INDenabling studies to ready the compound for Phase 1 clinical trials in healthy volunteers and chronic HBV patients. Combination regimens that include a CpAM, antivirals possessing distinct mechanisms of action and/or novel immunomodulatory agents will be evaluated in a mouse model of HBV infection in preparation for Phase 2 development in chronic HBV patienst.
项目总结

项目成果

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Glen Andrew Coburn其他文献

Glen Andrew Coburn的其他文献

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{{ truncateString('Glen Andrew Coburn', 18)}}的其他基金

Discovery of antiviral inhibitors for the treatment of orthopoxvirus infections
发现治疗正痘病毒感染的抗病毒抑制剂
  • 批准号:
    10761185
  • 财政年份:
    2023
  • 资助金额:
    $ 100万
  • 项目类别:
Optimization of orally bioavailable inhibitors for the treatment of COVID-19 and other human coronavirus infections
用于治疗 COVID-19 和其他人类冠状病毒感染的口服生物可利用抑制剂的优化
  • 批准号:
    10698831
  • 财政年份:
    2023
  • 资助金额:
    $ 100万
  • 项目类别:
Preclinical development of capsid assembly modulators for the treatment of chronic hepatitis B virus infection
用于治疗慢性乙型肝炎病毒感染的衣壳组装调节剂的临床前开发
  • 批准号:
    10612081
  • 财政年份:
    2021
  • 资助金额:
    $ 100万
  • 项目类别:
Preclinical development of capsid assembly modulators for the treatment of chronic hepatitis B virus infection
用于治疗慢性乙型肝炎病毒感染的衣壳组装调节剂的临床前开发
  • 批准号:
    10408826
  • 财政年份:
    2021
  • 资助金额:
    $ 100万
  • 项目类别:
Discovery of inhibitors that target HBx for the treatment of chronic HBV infection
发现针对 HBx 的抑制剂用于治疗慢性 HBV 感染
  • 批准号:
    10319178
  • 财政年份:
    2020
  • 资助金额:
    $ 100万
  • 项目类别:
Discovery of antiviral inhibitors of Ebola virus replication
发现埃博拉病毒复制的抗病毒抑制剂
  • 批准号:
    10216627
  • 财政年份:
    2020
  • 资助金额:
    $ 100万
  • 项目类别:
Discovery of inhibitors that target HBx for the treatment of chronic HBV infection
发现针对 HBx 的抑制剂用于治疗慢性 HBV 感染
  • 批准号:
    10155986
  • 财政年份:
    2020
  • 资助金额:
    $ 100万
  • 项目类别:
Discovery of inhibitors of Zika virus
寨卡病毒抑制剂的发现
  • 批准号:
    9252886
  • 财政年份:
    2017
  • 资助金额:
    $ 100万
  • 项目类别:
Discovery of inhibitors of BK polyomavirus
BK 多瘤病毒抑制剂的发现
  • 批准号:
    9308839
  • 财政年份:
    2016
  • 资助金额:
    $ 100万
  • 项目类别:
Discovery of inhibitors of BK polyomavirus
BK 多瘤病毒抑制剂的发现
  • 批准号:
    9200219
  • 财政年份:
    2016
  • 资助金额:
    $ 100万
  • 项目类别:

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