The efferent synapse in enteroendocrine cells

肠内分泌细胞中的传出突触

• 批准号: 10258314
• 负责人: Diego V Bohorquez
• 金额: $ 4.03万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-16 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10258314
• 关键词: Administrative Supplement; Back; Behavior; Behavior Disorders; Brain; Enteroendocrine Cell; Gastrointestinal tract structure; Goals; Japan; Laboratories; Learning; Medicinal Plants; Methodology; Nerve; Parents; Peripheral Nerves; Plants; Primates; Research; Research Institute; Self Medication; Sensory; Signal Transduction; Synapses; System; Testing; Translating; United States National Institutes of Health; Universities; Visit; Work; gastrointestinal; parent grant; programs; relating to nervous system; skills

Abstract. The long-term goal of our parent research program is to document how the gastrointestinal (GI) tract transduces luminal signals to the brain via peripheral nerves and how these nerves modulate GI sensory function. The goal of this US-Japan BRPC administrative supplement is for Dr. Diego Bohórquez (parent grant P.I) who is a neuroscientist at Duke University (Durham, NC, USA) to visit Dr. Michael Huffman who is a primate behaviorist at the Primate Research Institute of Kyoto University (Nagoya, Japan). The goal of the visit is to acquire advanced research skills and start to conduct collaborative research to uncover the neural basis of self-medication. In particular, and related to the goals of the R21AT010818 NIH-NCCIH parent grant “The efferent synapse in enteroendocrine cells”, the visit will have two specific aims: 1. To learn the scientific methodology used to study self-medication in primates in the field at the Primate Research Institute. 2. To identify potential medicinal plants and compounds to test back at Duke University. Once characterized these compounds could be used to alleviated behavioral disorders by targeting gut sensory function. By learning how self-medicating behaviors are identified and studied in the wild, we will be able to translate that work to our laboratory. Moreover, by identifying plants with medicinal values, these compounds could be used to modulate gut sensory function in an effort to treat behavioral disorders by modulating gut sensory function.

抽象。 我们的研究计划的长期目标是记录胃肠道（GI） 束通过外周神经将管腔信号传递到大脑，以及这些神经如何 调节GI感觉功能。这一美日BRPC行政补充的目标是， 博士Diego Bohórquez（父母格兰特P.I）是杜克大学（达勒姆，NC， 美国）拜访灵长类动物研究所的灵长类动物行为学家迈克尔霍夫曼博士 京都大学（日本名古屋）。访问的目标是获得先进的研究技能 并开始进行合作研究，以揭示自我药疗的神经基础。在 特别是，并与R21 AT 010818 NIH-NCCIH父母补助金的目标“传出 肠内分泌细胞的突触”，是次参观有两个目的： 1.学习用于研究该领域灵长类动物自我药疗的科学方法 在灵长类动物研究所。 2.去鉴定有潜力的药用植物和化合物然后回杜克大学测试。 一旦这些化合物被鉴定， 通过瞄准肠道感觉功能。 通过学习如何在野外识别和研究自我治疗行为，我们将能够 将这些成果转化到我们的实验室。此外，通过鉴定具有药用价值的植物， 这些化合物可用于调节肠道感觉功能， 通过调节肠道感觉功能而引起的疾病。