Systems-level analysis of the regulation and function of MYC

目的：在这个项目中，我们将使用计算和实验技术的结合来表征MYC在各种细胞系统中的动态，以及对一系列重要生物刺激的反应。我们将使用一系列定量方法（MYC蛋白表达的单细胞成像，MYC结合的全基因组分析，高通量转录组学分析等）来确定MYC调控和功能的系统水平特性。从这些方法中，我们的目标是开发在疾病背景下操纵MYC活性的新策略，特别是在MYC不受管制的癌症中。由于Batchelor博士的离职，该项目的进展于2020财年完成

PURPOSE: In this project, we will use a combination of computational and experimental techniques to characterize MYC dynamics in a variety of cell systems and in response to a range of important biological stimuli. We will use a range of quantitative approaches (single cell imaging of MYC protein expression, genome-wide analysis of MYC binding, high throughput transcriptomic analysis, etc) to identify systems-level properties of MYC regulation and function. From these approaches, we aim to develop novel strategies for manipulating MYC activity in disease contexts, especially cancers in which MYC is deregulated. Progress on this project was complete in FY20 due to Dr. Batchelor's departure