TERBO BRAIN Study: Trajectories of Emotional Regulation and Behavior Outcomes and related Brain Regions And Intrinsic Networks
TERBO BRAIN 研究:情绪调节和行为结果的轨迹以及相关的大脑区域和内在网络
基本信息
- 批准号:10264955
- 负责人:
- 金额:$ 43.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-18 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AccountingAddressAdolescenceAdolescentAdultAffectAffectiveAgeAnti-Retroviral AgentsAttenuatedAutomobile DrivingBehaviorBehavior assessmentBehavioralBrainBrain regionBreast FeedingCessation of lifeChildChildhoodClinicalCognitionCognitiveCollaborationsComputersDataDevelopmentDiscriminationDiseaseEducationEmotionalEmotionsEnrollmentExhibitsExposure toFamilyFundingGenderGeneral PopulationGrowthHIVHIV InfectionsHIV antiretroviralHIV/STDHealthHomelessnessHumanImpaired cognitionImpairmentImprisonmentInfectionInformal Social ControlInterventionInvestigationLanguageLifeLightLinkMeasuresMediatingMediationMental HealthMental disordersModelingMonitorMulticenter StudiesNeurocognitiveOutcomeParticipantPediatric HIV/AIDS Cohort StudyPerinatalPerinatal ExposurePersonal SatisfactionPharmaceutical PreparationsPopulationProtocols documentationPsychopathologyPublic HealthRegulationResearchRewardsRiskRisk BehaviorsRisk-TakingSafetySamplingStructureTimeToxic effectUnited States National Institutes of HealthUnsafe SexViolenceVocationWomanYouthadolescent substance useantiretroviral therapyattenuationbasebehavioral outcomebrain abnormalitiescognitive functioncohortcongenital anomalyconnectomeearly childhoodefavirenzemotion regulationemotional behaviorexperienceimprovedin uterolarge scale datanetwork dysfunctionneurodevelopmentneuroimagingneuromechanismneurotoxicpediatric human immunodeficiency virus infectionperinatal HIVpoor communitiespregnantprenatalprenatal exposurepreventive interventionprotective factorsrecruitskill acquisitionskillssocial structuresubstance usesuccesssupport networksurveillance studyyoung adult
项目摘要
PROJECT SUMMARY
An estimated 15 million children worldwide are living with perinatal HIV and antiretroviral (ARV) exposure, but
are HIV-uninfected (PHEU). Recent studies reveal cognitive challenges, mental health problems, and
increased rates of risk-taking behaviors including substance use among youth with PHEU (YPHEU). Existing,
cross-sectional neuroimaging studies indicate disrupted brain development among YPHEU, yet the underlying
neural mechanisms, particularly related to prenatal HIV and ARV exposure, are not well understood.
Dysfunction of networks supporting emotional regulation has been linked with childhood psychopathologies
and risk-taking behavior in youth, yet we know little in YPHEU despite increased risk behaviors. We propose a
longitudinal investigation to address these gaps in our current understanding. Our central hypothesis is that
disruption of networks supporting emotion regulation, and interaction with other developmental risks, are key to
understanding deficits in mental health, cognition and behavior in YPHEU. We will assess brain network
development, mental health, self-regulation and other cognitive domains, and risk-taking behavior, utilizing
functional and structural neuroimaging, clinical and computer-based assessments and tasks, in 190 YPHEU
(10-14 years) at baseline, and 2 years later. Participants will be recruited from the Pediatric HIV/AIDS Cohort
Study (PHACS) Surveillance Monitoring of ART Toxicity Study (SMARTT). Aim 1 will leverage harmonized
age- and gender-matched neuroimaging and behavioral data from the NIH funded ABCD study on over 10,000
children age 9-10 years followed yearly, to compare with trajectories of brain network development, cognition
and behavior, as well as their relationships among YPHEU. Aim 2 will examine the impact of type and timing of
perinatal ARVs and other perinatal exposures such as substance use on brain network development within
YPHEU. We will also examine social and structural factors that may have independent effects on brain
development or interact with perinatal exposures. To further our understanding of lifetime implications of
perinatal exposures, exploratory Aim 3 will explore long-term brain network and behavioral consequences, and
their effect on transition to adult independence, in 50 young adults with PHEU and 50 with perinatally acquired
HIV (PHIV), age 22-29, enrolled in the PHACS Adolescent Master Protocol-Up (AMP Up) study. We will
leverage harmonized age- and gender-matched healthy young adult neuroimaging and behavioral data from
the NIH funded Human Connectome Project to compare outcomes. Recognizing significant public health
implications of the effects of ARV exposure on long-term cognitive and behavioral outcomes among YPHEU,
this project, leveraging multiple NIH-supported multicenter studies and established collaborations, will identify
mechanisms driving cognitive and behavioral outcomes, critical data for informing much needed prevention
and intervention strategies for the staggering numbers of YPHEU globally.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lei Wang其他文献
Palladium-Catalyzed ortho-Acylation of Acetanilides with Aldehydes via Direct CH Bond Activation.
通过直接 C·H 键活化,钯催化乙酰苯胺与醛的邻位酰化。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Chengliang Li;Lei Wang;Pinhua Li;Wei Zhou - 通讯作者:
Wei Zhou
KOAc-promoted alkynylation of alpha-C-H bonds of ethers with alkynyl bromides under transition-metal-free conditions
无过渡金属条件下 KOAc 促进醚的 α-C-H 键与炔基溴的炔基化
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:3.2
- 作者:
Jiajun Zhang;Pinhua Li;Lei Wang - 通讯作者:
Lei Wang
Lei Wang的其他文献
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{{ truncateString('Lei Wang', 18)}}的其他基金
Covalent Protein Binders for Cancer Research and Therapy
用于癌症研究和治疗的共价蛋白结合剂
- 批准号:
10360531 - 财政年份:2021
- 资助金额:
$ 43.03万 - 项目类别:
Covalent Protein Binders for Cancer Research and Therapy
用于癌症研究和治疗的共价蛋白结合剂
- 批准号:
10179199 - 财政年份:2021
- 资助金额:
$ 43.03万 - 项目类别:
Covalent Protein Binders for Cancer Research and Therapy
用于癌症研究和治疗的共价蛋白结合剂
- 批准号:
10569518 - 财政年份:2021
- 资助金额:
$ 43.03万 - 项目类别:
TERBO BRAIN Study: Trajectories of Emotional Regulation and Behavior Outcomes and related Brain Regions And Intrinsic Networks
TERBO BRAIN 研究:情绪调节和行为结果的轨迹以及相关的大脑区域和内在网络
- 批准号:
10663934 - 财政年份:2020
- 资助金额:
$ 43.03万 - 项目类别:
TERBO BRAIN Study: Trajectories of Emotional Regulation and Behavior Outcomes and related Brain Regions And Intrinsic Networks
TERBO BRAIN 研究:情绪调节和行为结果的轨迹以及相关的大脑区域和内在网络
- 批准号:
10065446 - 财政年份:2020
- 资助金额:
$ 43.03万 - 项目类别:
Schwann cell derived exosomes improve diabetic peripheral neuropathy in type II diabetic mice
雪旺细胞衍生的外泌体改善 II 型糖尿病小鼠的糖尿病周围神经病变
- 批准号:
10121320 - 财政年份:2020
- 资助金额:
$ 43.03万 - 项目类别:
Schwann cell derived exosomes improve diabetic peripheral neuropathy in type II diabetic mice
雪旺细胞衍生的外泌体改善 II 型糖尿病小鼠的糖尿病周围神经病变
- 批准号:
10413254 - 财政年份:2020
- 资助金额:
$ 43.03万 - 项目类别:
Schwann cell derived exosomes improve diabetic peripheral neuropathy in type II diabetic mice
雪旺细胞衍生的外泌体改善 II 型糖尿病小鼠的糖尿病周围神经病变
- 批准号:
10643939 - 财政年份:2020
- 资助金额:
$ 43.03万 - 项目类别:
Macula densa NOS1 and transplanted renal graft function
致密斑NOS1与移植肾功能
- 批准号:
10609888 - 财政年份:2020
- 资助金额:
$ 43.03万 - 项目类别:
Schwann cell derived exosomes improve diabetic peripheral neuropathy in type II diabetic mice
雪旺细胞衍生的外泌体改善 II 型糖尿病小鼠的糖尿病周围神经病变
- 批准号:
10262969 - 财政年份:2020
- 资助金额:
$ 43.03万 - 项目类别:
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