Bidirectional Interactions of Cortex and Basal Ganglia During Action Selection
动作选择过程中皮层和基底神经节的双向相互作用
基本信息
- 批准号:10265465
- 负责人:
- 金额:$ 7.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-15 至 2023-09-14
- 项目状态:已结题
- 来源:
- 关键词:AddressAnatomyAnimalsAnteriorBasal GangliaBehaviorBrainCalciumCellsCollaborationsCommunitiesCorpus striatum structureDataDecision MakingDiseaseElectrophysiology (science)EnvironmentFeedbackFellowshipFoundationsFunctional disorderFutureGoalsHeadHuntington DiseaseImageKnowledgeLaboratoriesLateralModificationMonitorMotorMotor CortexMotor outputMovementMusNeurobiologyNeuronsOutcomeOutputParkinson DiseasePathway interactionsPatternPhysiologyProcessPublishingRampRecording of previous eventsRecurrenceResearchResource DevelopmentRewardsRodentSelectinsSignal TransductionSiteStructureTechnologyTestingTrainingUpdateWorkawakebasecareer developmentcomputational neurosciencedensityexperienceexperimental studyextracellularimprovedinnovationinsightmedical schoolsnoveloptogeneticsoutcome predictionprogramsrelating to nervous systemskill acquisitiontooltwo photon microscopytwo-photon
项目摘要
Project Summary/Abstract
Selecting future actions based on previous experiences is key to an animal's survival. This process, known as
action selection, depends on the proper function of cortical and subcortical basal ganglia circuits. Despite the
importance of these regions for using previous experiences to inform upcoming motor choices, we do not
understand the precise mechanisms by which these regions work together and the activity patterns they use to
select actions. The significance of these regions in action selection is clear in disorders that arise from cortical
and basal ganglia dysfunction. One hypothesis is that the cortex develops motor plans that the basal ganglia
then executes and evalulates based on outcome. Based on anatomy, we know that cortex and basal ganglia
form a recurrent loop in the brain, however we do not understand how the two work together to promote and
select actions. This gap in knowledge is due in part to our lack of technology to assess and perturb cortex and
basal ganglia simultaneously. In this proposal, I will overcome these limitations by examining the recurrent
interactions between the cortex and basal ganglia during ongoing action selectin. I will focus on the mouse
anterior lateral motor cortex (ALM) and the striatum, the primary input nucleus of the basal ganglia. My
overarching hypothesis that striatal activity is modified based on action outcome and its recurrent feedback to
ALM is necessary to update subsequent motor planning required for action selection. To test my hypothesis, I
plan to implement 2-photon calcium imaging in ALM, large-scale electrophysiology in striatum, site-specific
striatal perturbations, and a two-choice motor task which uses past information to produce future actions. In this
proposal, I will determine 1) how striatal activity influences motor planning in ALM during action selection, and
2) if striatal activity is necessary for proper action updating in ALM during action selection. Together, these aims
will tell us how cortical and striatal circuits dynamically interact to produce ongoing behavior. My research goals
are to investigate the fundamental mechanisms by which striatum and cortex contribute to action selection. My
academic goals are to build a strong foundation in computational neuroscience and continue to improve the
career development skills I will need for my transition to independence at the end of this fellowship. The lab of
my sponsor, Dr. Bernardo Sabatini, and the Harvard Medical School community will provide an excellent training
environment for this fellowship. Dr. Sabatini is a leading expert in basal ganglia physiology, 2-photon imaging,
and the analysis of neural data. The Sabatini lab and the Department of Neurobiology at Harvard Medical School
will provide excellent career development resources for training in neurobiology with a strong focus on
collaboration and scientific innovation.
项目总结/摘要
根据以前的经验选择未来的行动是动物生存的关键。这个过程,被称为
动作选择取决于皮质和皮质下基底神经节回路的适当功能。尽管
这些区域对于使用以前的经验来告知即将到来的运动选择的重要性,我们不
了解这些地区协同工作的确切机制以及它们用来
选择操作。这些区域在动作选择中的重要性在由皮层神经元引起的疾病中是清楚的。
和基底神经节功能障碍。一种假设是大脑皮层制定运动计划,
然后执行并根据结果进行评估。基于解剖学,我们知道大脑皮层和基底神经节
在大脑中形成一个循环回路,但我们不知道两者如何共同作用,
选择操作。这种知识上的差距部分是由于我们缺乏技术来评估和干扰大脑皮层,
基底神经节同时在本建议中,我将通过审查经常性的
皮质和基底神经节之间的相互作用,在进行中的行动选择素。我会专注于鼠标
前外侧运动皮层(ALM)和纹状体,基底神经节的初级输入核。我
总体假设,纹状体的活动是基于行动结果及其经常性反馈进行修改,
ALM对于更新动作选择所需的后续运动规划是必要的。为了验证我的假设,我
计划在ALM中实施双光子钙成像,在纹状体中实施大规模电生理学,
纹状体扰动,和一个双选择运动任务,使用过去的信息,以产生未来的行动。在这
建议,我将确定1)纹状体活动如何影响动作选择过程中的ALM运动规划,
2)在动作选择过程中,纹状体活动对于ALM中的适当动作更新是否是必要的。总之,这些目标
将告诉我们皮层和纹状体回路如何动态地相互作用以产生持续的行为。我的研究目标
目的是研究纹状体和皮层参与动作选择的基本机制。我
学术目标是在计算神经科学方面建立坚实的基础,并继续提高
我将需要职业发展技能,以便在本奖学金结束时向独立过渡。的实验室
我的赞助人贝尔纳多·萨巴蒂尼博士和哈佛医学院将提供一个很好的培训
环境对于这个奖学金。萨巴蒂尼博士是基底神经节生理学,双光子成像,
和神经数据的分析。萨巴蒂尼实验室和哈佛医学院神经生物学系
将为神经生物学培训提供优秀的职业发展资源,重点是
合作和科学创新。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Allison Elizabeth Girasole其他文献
Allison Elizabeth Girasole的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Allison Elizabeth Girasole', 18)}}的其他基金
Bidirectional Interactions of Cortex and Basal Ganglia During Action Selection
动作选择过程中皮层和基底神经节的双向相互作用
- 批准号:
10480941 - 财政年份:2020
- 资助金额:
$ 7.14万 - 项目类别:
相似海外基金
Linking Epidermis and Mesophyll Signalling. Anatomy and Impact in Photosynthesis.
连接表皮和叶肉信号传导。
- 批准号:
EP/Z000882/1 - 财政年份:2024
- 资助金额:
$ 7.14万 - 项目类别:
Fellowship
Digging Deeper with AI: Canada-UK-US Partnership for Next-generation Plant Root Anatomy Segmentation
利用人工智能进行更深入的挖掘:加拿大、英国、美国合作开发下一代植物根部解剖分割
- 批准号:
BB/Y513908/1 - 财政年份:2024
- 资助金额:
$ 7.14万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Social and ecological influences on brain anatomy
博士论文研究:社会和生态对大脑解剖学的影响
- 批准号:
2235348 - 财政年份:2023
- 资助金额:
$ 7.14万 - 项目类别:
Standard Grant
Simultaneous development of direct-view and video laryngoscopes based on the anatomy and physiology of the newborn
根据新生儿解剖生理同步开发直视喉镜和视频喉镜
- 批准号:
23K11917 - 财政年份:2023
- 资助金额:
$ 7.14万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Computational comparative anatomy: Translating between species in neuroscience
计算比较解剖学:神经科学中物种之间的翻译
- 批准号:
BB/X013227/1 - 财政年份:2023
- 资助金额:
$ 7.14万 - 项目类别:
Research Grant
computational models and analysis of the retinal anatomy and potentially physiology
视网膜解剖学和潜在生理学的计算模型和分析
- 批准号:
2825967 - 财政年份:2023
- 资助金额:
$ 7.14万 - 项目类别:
Studentship
Genetics of Extreme Phenotypes of OSA and Associated Upper Airway Anatomy
OSA 极端表型的遗传学及相关上呼吸道解剖学
- 批准号:
10555809 - 财政年份:2023
- 资助金额:
$ 7.14万 - 项目类别:
Development of a novel visualization, labeling, communication and tracking engine for human anatomy.
开发一种新颖的人体解剖学可视化、标签、通信和跟踪引擎。
- 批准号:
10761060 - 财政年份:2023
- 资助金额:
$ 7.14万 - 项目类别:
Understanding the functional anatomy of nociceptive spinal output neurons
了解伤害性脊髓输出神经元的功能解剖结构
- 批准号:
10751126 - 财政年份:2023
- 资助金额:
$ 7.14万 - 项目类别:
The Anatomy of Online Reviews: Evidence from the Steam Store
在线评论剖析:来自 Steam 商店的证据
- 批准号:
2872725 - 财政年份:2023
- 资助金额:
$ 7.14万 - 项目类别:
Studentship