The Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers

总体总结 在美国，肥胖和肾结石的患病率在过去一直在稳步上升 几十年了。草酸钙结石是最常见的类型，包括在肥胖人群中。那里 是否有越来越多的证据表明肥胖与尿草酸排泄增加有关，这是一个重要的危险因素 草酸钙结石的形成。为了解决这个问题，我们建立了一个研究中心，该中心被赋予了 首字母缩写COOKS(肥胖和草酸肾结石研究中心)。本中心提供 创新科学研究平台以及教育和信息传播的基础设施。这个 研究项目将集中于确定肥胖者尿草酸排泄增加的原因 草酸盐成石器。这将通过建立一个多机构、协同、跨学科的 小组，包括在肾结石研究、肥胖、营养和肾脏以及 胃肠生理学。该科研项目将检查胃肠道和肾脏的影响。 草酸处理和内源性草酸合成对正常体重指数和肥胖成人尿草酸排泄的影响 草酸钙肾结石形成。既要利用现有的技术，也要利用新的技术。已建立 技术将包括扩展的饮食研究，其中草酸、钙和其他营养素的水平密切相关 控制住了。新技术将涉及代谢标记以跟踪草酸的处理和合成，以及状态 最先进的艺术成像技术。行政核心将监督研究和教育活动。 厨师的名字。它还将负责财务管理、维持合作以及 与NIDDK赞助的其他相关中心和项目官员进行沟通。教育内容的丰富 该计划将继续具有广泛的基础。已建立的网站将扩展并链接到UAB和 德克萨斯大学西南分校。该网站将促进教育活动并传播信息。 对泌尿外科社区、其他相关调查人员和公众。生成的数据应该会增加我们的 了解肥胖与尿草酸之间的关系、涉及的因素，并作为 开发预防肥胖者草酸钙肾结石的新疗法的平台。

OVERALL SUMMARY The prevalence of both obesity and kidney stone disease has been steadily increasing in the U.S. over the past several decades. Calcium oxalate stones are the most common type, including within the obese cohort. There is mounting evidence that obesity is associated with increased urinary oxalate excretion, an important risk factor for calcium oxalate stone formation. To address this issue, we have established a research center that was given the acronym COOKS (Center for research on Obesity and Oxalate Kidney Stones). This Center provides a platform for novel scientific research and the infrastructure for education and dissemination of information. The research project will focus on defining the reasons for the increased urinary oxalate excretion in obese calcium oxalate stone formers. This will be accomplished by establishing a multi-institutional, synergistic, interdisciplinary group, including scientists with unique backgrounds in kidney stone research, obesity, nutrition, and renal and gastrointestinal physiology. The scientific research project will examine the influence of gastrointestinal and renal oxalate handling, and endogenous oxalate synthesis on urinary oxalate excretion in normal BMI and obese adult calcium oxalate kidney stone formers. Both established and novel techniques will be utilized. Established techniques will include extended dietary studies where levels of oxalate, calcium and other nutrients are tightly controlled. Novel techniques will involve metabolic labelling to follow oxalate handling and synthesis, and state of the art imaging techniques. The administrative core will provide oversight of research and educational activities of COOKS. It will also be responsible for financial management, maintenance of collaborations, and communication with other pertinent NIDDK-sponsored centers and program officials. The education enrichment program will continue to be broad based. The established website will be expanded and linked to both UAB and the University of Texas Southwestern. This website will promote educational events and disseminate information to the Urologic community, other pertinent investigators and the public. The data generated should increase our understanding of the relationships between obesity and urinary oxalate, the factors involved, and serve as a platform to develop novel therapies for calcium oxalate kidney stone prevention in obese individuals.