Development of tissue oxygenation indices for acute wounds and diabetic foot ulcers using near-infrared imaging approach

使用近红外成像方法制定急性伤口和糖尿病足溃疡的组织氧合指数

• 批准号: 10266053
• 负责人: Kevin Leiva
• 金额: $ 3.66万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-27 至 2022-08-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10266053
• 关键词: Acute; Amputation; Blood flow; Calibration; Clinical; Complement; Data; Debridement; Dermatologist; Development; Devices; Diabetes Mellitus; Diabetic Foot Ulcer; Diagnosis; Doppler Ultrasound; Felis catus; Fellowship; Florida; Gold; Hand; Hemoglobin; Image; Individual; International; Laboratories; Lead; Learning; Leg Ulcer; Life; Longitudinal Studies; Maps; Measurement; Measures; Mentors; Methodology; Near-Infrared Spectroscopy; Near-infrared optical imaging; Operative Surgical Procedures; Optics; Outcome; Oxygen; Perfusion; Physiologic pulse; Physiological; Pilot Projects; Podiatry; Population; Process; Prognosis; Research; Research Design; Skin; Standardization; Surgeon; Techniques; Testing; Time; TimeLine; Transcutaneous Oximetry; Ulcer; United States; Universities; Validation; Venous; Visual; Visual Manifestations; acute wound; base; cost; experience; foot; healing; imaging approach; imaging modality; improved; in vivo; indexing; individualized medicine; innovation; light weight; non-diabetic; non-healing wounds; optical imaging; pressure; skin ulcer; spectrograph; tissue oxygenation; tool; treatment planning; two-dimensional; wound; wound care; wound dressing; wound healing; wound treatment

PROJECT SUMMARY Approximately 30.3 million individuals are diagnosed with Diabetes Mellitus (DM) in the United States, with approximately 25% of this population expected to develop a Diabetic Foot ulcer (DFU) at some point during their life. A major impasse in improving the wound management process is the lack of a validated tissue oxygenation parameter to assess healing. Despite efforts, the current gold-standard approach in DFU assessment remains visual inspection using a 50% reduction in wound size across 4 weeks to denote healing. The objective of this 2-year F31 fellowship is to develop and validate a static and dynamic wound healing index for acute (non-diabetic) and DFU wounds using two-dimensional tissue oxygenation and dynamic correlation maps from a non-contact, wide field near infrared optical scanner (NIROS) for near real-time assessment of DFUs. Validation and calibration of oxygenation-based parameter(s) from in-vivo studies on controls using NIROS will be conducted. Utilizing the calibrated NIROS, tissue oxygenation (TO)-based indices will be developed to predict wound healing potential and oxygenation flow adequacy. Oxygenation measurements will be correlated to visual signs of healing, and thresholds will be developed to indicate the healing status in acute wounds. Once established, DFU healing indices will be developed using the same methodology, and employing the acute wound indices as a baseline. The development of DFU healing indices, in turn, could serve as a valuable tool for clinicians to assess the state of the wound and better cater/modify the treatment plan as needed.

项目摘要 在美国，大约有3030万人被诊断患有糖尿病（DM）， 预计该人群中约25%的人会在治疗期间的某个时间点发生糖尿病足溃疡（DFU）。 他们的生活.改进伤口处理过程的一个主要僵局是缺乏有效的组织 氧合参数以评估愈合。尽管做出了努力，DFU目前的金本位方法 评估仍然是目视检查，使用4周内伤口尺寸减少50%来表示愈合。 这个为期2年的F31奖学金的目的是开发和验证静态和动态伤口愈合指数 用于急性（非糖尿病）和DFU伤口，使用二维组织氧合和动态相关性 来自非接触式宽视场近红外光学扫描仪（NIROS）的地图，用于近实时评估 DFU。使用以下方法对来自对照体内研究的氧合参数进行验证和校准 将进行NIROS。利用经校准的NIROS，基于组织氧合（TO）的指数将被 开发用于预测伤口愈合潜力和氧合流量充分性。氧合测量将 与视觉愈合迹象相关，并将制定阈值来指示急性愈合状态 伤口一旦确定，DFU愈合指数将使用相同的方法开发， 采用急性创伤指数作为基线。DFU愈合指数的发展反过来又可以 作为临床医生评估伤口状态和更好地迎合/修改治疗的有价值的工具 根据需要制定计划。