A Data Coordinating Center for ENCODE

ENCODE 数据协调中心

• 批准号: 10240216
• 负责人: J. Michael Cherry
• 金额: $ 479.92万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10240216
• 关键词: Biological; Biological Assay; Biomedical Research; Cells; Communities; Computer Analysis; Computer software; Data; Data Coordinating Center; Development; Disease; Documentation; Elements; Goals; Gold; Health; Human; Human Characteristics; Human Genome; Laboratories; Metadata; Methods; Modeling; Participant; Procedures; Process; Production; Public Health; Quality Control; Reproducibility; Sampling; Structure; Tissues; Validation; biological research; complex data; data analysis pipeline; data resource; data standards; data submission; data warehouse; design; distributed data; experience; genomic data; meetings; service organization; tool; verification and validation; webinar

Project Summary The goals of the ENCODE Data Coordinating Center (DCC) is to support the ENCODE Consortium by defining and establishing a strategy that connects all participants to the data and by creating avenues of access that distribute these data to the greater biological research community. The ENCODE Consortium brings together laboratories that generate complex data types via experimental assays with laboratories that integrate these unique data using computational analyses to discover how chromosomal elements function together to define human cells and tissues. The DCC's participation enhances the data created by these laboratories through the creation of structured procedures for the verification and validation of all submitted data and providing processes for the documentation of metadata that describe each biological sample and assay method. To facilitate access to all the data created the DCC will construct a state of the art data warehouse. The DCC will design and development robust software to enhance the data submission and unified data processing pipelines, the organization and access to metadata and the data warehouse. In addition, we will develop and maintain the ENCODE Portal that will be the primary entry point to the wealth of experimentally determined information as well as results of computational analyses. The Portal will integrate these data resources and make them available via enhanced search and browsing capabilities. Tools will be implemented to aid discovery by both experienced bioinformaticians and naïve laboratory staff. The DCC will evolve into a substantial service organization allowing biomedical research to take full advance of the ENCODE results. To this end the DCC will provide documentation via many media including written documentation, video tutorials, webinars, and meeting presentations. The DCC, DAC, production laboratories and AWG will be tightly woven together to create the ENCODE Consortium.

项目总结