A Data Coordinating Center for ENCODE

ENCODE 数据协调中心

• 批准号: 10240216
• 负责人: J. Michael Cherry
• 金额: $ 479.92万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10240216
• 关键词: Biological; Biological Assay; Biomedical Research; Cells; Communities; Computer Analysis; Computer software; Data; Data Coordinating Center; Development; Disease; Documentation; Elements; Goals; Gold; Health; Human; Human Characteristics; Human Genome; Laboratories; Metadata; Methods; Modeling; Participant; Procedures; Process; Production; Public Health; Quality Control; Reproducibility; Sampling; Structure; Tissues; Validation; biological research; complex data; data analysis pipeline; data resource; data standards; data submission; data warehouse; design; distributed data; experience; genomic data; meetings; service organization; tool; verification and validation; webinar

Project Summary The goals of the ENCODE Data Coordinating Center (DCC) is to support the ENCODE Consortium by defining and establishing a strategy that connects all participants to the data and by creating avenues of access that distribute these data to the greater biological research community. The ENCODE Consortium brings together laboratories that generate complex data types via experimental assays with laboratories that integrate these unique data using computational analyses to discover how chromosomal elements function together to define human cells and tissues. The DCC's participation enhances the data created by these laboratories through the creation of structured procedures for the verification and validation of all submitted data and providing processes for the documentation of metadata that describe each biological sample and assay method. To facilitate access to all the data created the DCC will construct a state of the art data warehouse. The DCC will design and development robust software to enhance the data submission and unified data processing pipelines, the organization and access to metadata and the data warehouse. In addition, we will develop and maintain the ENCODE Portal that will be the primary entry point to the wealth of experimentally determined information as well as results of computational analyses. The Portal will integrate these data resources and make them available via enhanced search and browsing capabilities. Tools will be implemented to aid discovery by both experienced bioinformaticians and naïve laboratory staff. The DCC will evolve into a substantial service organization allowing biomedical research to take full advance of the ENCODE results. To this end the DCC will provide documentation via many media including written documentation, video tutorials, webinars, and meeting presentations. The DCC, DAC, production laboratories and AWG will be tightly woven together to create the ENCODE Consortium.

项目摘要 ENCODE数据协调中心（DCC）的目标是通过定义 建立一个将所有参与者与数据联系起来的战略，并通过创建访问渠道， 将这些数据分发给更大的生物研究社区。ENCODE联盟汇集了 实验室通过实验分析生成复杂的数据类型，实验室将这些 使用计算分析的独特数据来发现染色体元件如何共同作用以定义 人体细胞和组织。DCC的参与增强了这些实验室通过 建立结构化程序，以核实和确认所有提交的数据，并提供 用于记录描述每个生物样品和测定方法的元数据的过程。到 为了方便访问DCC创建的所有数据，DCC将构建一个最先进的数据仓库。DCC将 设计和开发强大的软件，以加强数据提交和统一数据处理 管道、元数据和数据仓库的组织和访问。此外，我们将开发和 维护ENCODE门户网站，这将是实验确定的财富的主要入口点 信息以及计算分析的结果。门户网站将整合这些数据资源， 通过增强的搜索和浏览功能使它们可用。将实施各种工具， 这是由经验丰富的生物信息学家和天真的实验室工作人员共同发现的。DCC将演变成一个 一个实质性的服务组织，使生物医学研究能够充分利用ENCODE的成果。到 为此，DCC将通过许多媒体提供文档，包括书面文档，视频教程， 网络研讨会和会议演示。DCC、DAC、生产实验室和AWG将紧密交织在一起 共同创建了ENCODE联盟。