Colombia-U.S. Fogarty training program on the impact of emerging zoonotic and vector-borne diseases in acute undifferentiated febrile illnesses

哥伦比亚-美国

• 批准号: 10240140
• 负责人: Patricia Veronica Aguilar
• 金额: $ 30.1万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10240140
• 关键词: 2019-nCoV; Acute; Address; Awareness; Bioethics; Bioinformatics; Colombia; Colombian; Country; Dengue; Diagnosis; Diagnostic Procedure; Disease; Doctor of Philosophy; Educational workshop; Electron Microscopy; Enrollment; Ensure; Ethics; Faculty; Fever; Funding; Goals; Grant; Health Personnel; Health Professional; Human; Incidence; Infectious Diseases Research; Institution; Laboratories; Latin America; Leadership; Manuscripts; Mentorship; Methodology; Methods; Molecular; Morbidity - disease rate; Outcome; Postdoctoral Fellow; Preparation; Progress Reports; Public Health; Research; Research Methodology; Research Training; Science; Scientist; Students; Testing; Trainers Training; Training; Training Programs; Training Support; Undifferentiated; Vector-transmitted infectious disease; Visit; Writing; Zoonoses; authority; design; doctoral student; expectation; influenzavirus; interest; low and middle-income countries; member; mortality; novel; novel diagnostics; pathogen; pre-doctoral; programs; recruit; respiratory virus

Abstract Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most low-and middle-income countries, only a handful of “dengue” cases are confirmed by laboratory testing and therefore many other pathogens remain hidden under the dengue “umbrella”. Lack of proper training among scientists and health care workers was recognized as one of the major obstacles in the diagnosis of AUFIs. To fill this gap, our D43 Global Infectious Disease Research Training Program was launched in 2016, with the goal of forming a strong team of scientists studying non-malarial acute undifferentiated febrile illnesses (AUFIs) in Colombia. Since then, the program has filled a major gap. Over the past five years, we completed advanced training of Colombian Faculty members, predoctoral and postdoctoral students, and conducted short-term training on grant writing and manuscript preparation. The program encompassed short, medium, and long-term research training, and it has exceeded expectations (see Progress Report). The past five years has allowed us to identify additional gaps, challenges, and opportunities. Our new proposed activities will build on our accomplishments and continue to build capacity and train a new group of Colombian Faculty members, PhD students and postdoctoral fellows studying the emerging zoonotic and vector-borne diseases. We will expand the focus of our D43 training program to address respiratory viruses, including SARS-CoV-2 and influenza viruses. We will incorporate training of master’s students enrolled in the Master’s in Basic Biomedical Sciences and implement training on novel molecular and bioinformatic methods, electron microscopy, novel diagnostic methods, grant writing, scientific writing, ethics in scientific research, and biosafety, and for Colombian Faculty, PhD students and postdoctoral fellows, research leadership. Our carefully designed plan includes: 1) In Years 1 and 2, we will support medium-term training of six Colombian Faculty members under a “train the trainer” approach, 2) In Years 1 and 2, we will recruit and support in-country long-term training of master’s students interested in emerging zoonotic and vector-borne diseases working under the mentorship of the Colombian Program Faculty, 3) In Years 3 through 5, we will recruit and support long-term training of PhD, and postdoctoral fellows in the US in advanced research methodologies, scientific writing, biosafety, and bioethics, and, 4) we will conduct short-term in country training in Colombia to ensure appropriate implementation of methodologies, and also conduct specific workshops. We will continue to support training across institutions in the region through in- country visits of US Faculty members and funds will be available for pilot and reinsertion small grants after completion of training. An important planned outcome is the increased awareness of these diseases at the level of human and veterinary health professionals, as well as public health authorities.

摘要 非疟疾性急性未分化发热性疾病（AUFI）是疟疾发病率和死亡率的重要原因， 近年来，登革热样疾病的发病率急剧增加。在大多数 在低收入和中等收入国家，只有少数“登革热”病例得到实验室检测的确认， 因此，许多其他病原体仍然隐藏在登革热“保护伞”之下。缺乏适当的培训， 科学家和卫生保健工作者被认为是诊断AUFI的主要障碍之一。到 为了填补这一空白，我们的D43全球传染病研究培训计划于2016年启动，目标是 成立一个强大的科学家团队，研究非疟疾急性未分化发热性疾病（AUFI）， 哥伦比亚.从那时起，该计划填补了一个重大空白。在过去的五年里，我们完成了先进的 培训哥伦比亚教师，博士前和博士后学生，并进行短期 关于赠款撰写和手稿准备的培训。该计划包括短期，中期和长期 研究培训，并已超出预期（见进度报告）。过去的五年让我们 找出更多的差距、挑战和机遇。我们新提议的活动将建立在我们的 成就，并继续建设能力，培养一批新的哥伦比亚教师，博士 研究新出现的人畜共患疾病和病媒传播疾病的学生和博士后研究员。我们将扩大 我们D43培训计划的重点是解决呼吸道病毒，包括SARS-CoV-2和流感 病毒我们将把培养硕士生纳入基础生物医学科学硕士课程 并实施新的分子和生物信息学方法，电子显微镜，新的诊断 方法，赠款写作，科学写作，科学研究伦理和生物安全，并为哥伦比亚学院， 博士生和博士后研究员，研究领导。我们精心设计的计划包括：1）在第一年 第二，我们将支持在“培训培训员”项目下对六名哥伦比亚教员进行中期培训。 方法，2）在第1年和第2年，我们将招募和支持硕士生的国内长期培训 对新出现的人畜共患病和病媒传播疾病感兴趣， 3）在第三年到第五年，我们将招募和支持博士和博士后的长期培训 研究员在美国先进的研究方法，科学写作，生物安全和生物伦理学，和，4）我们将 在哥伦比亚进行短期的国家培训，以确保适当执行这些方法， 还举办专题研讨会。我们将继续支持该地区各机构的培训， 美国教师和基金的国家访问将提供试点和重新安置小额赠款后， 完成培训。一个重要的计划成果是提高各级对这些疾病的认识， 人类和兽医卫生专业人员以及公共卫生当局。