The Administrative Core will support Udall Center activities at the University of Rochester

行政核心将支持罗切斯特大学尤德尔中心的活动

• 批准号: 10242053
• 负责人: Earl Ray Dorsey
• 金额: $ 28.02万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242053
• 关键词: Advocacy; Big Data; Caring; Cellular Phone; Clinical Markers; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Communities; Computational Science; Computers; Country; Data Science; Data Scientist; Development; Disease Progression; Disease model; Electrical Engineering; Enrollment; FDA approved; Fellowship; Fellowship Program; Funding; Generations; Genetic Markers; Grant; Health; Health Technology; Individual; Infrastructure; Institutes; Institution; Interdisciplinary Study; Investigational Therapies; Leadership; Mission; Movement Disorders; Neurology; Participant; Pharmacologic Substance; Positioning Attribute; Randomized Controlled Trials; Recording of previous events; Research; Research Personnel; Resources; Role; Scientist; Technology; Telemedicine; Therapeutic; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; University resources; advanced analytics; advocacy organizations; career development; clinical center; health professional shortage areas; human capital; innovation; multidisciplinary; novel; novel strategies; outreach; research and development; research study; tool; virtual; wearable sensor technology

SUMMARY The UR-Udall Center's Administrative Core will utilize the established resources of the University of Rochester's Center for Health + Technology (CHeT). Over the past 25 years, CHeT has pioneered multi-center research studies that have enrolled 40,000 individuals in 120 studies that have led to seven FDA-approved therapies, including four for PD. More recently, CHeT has used technology to transform PD research and care. Among these PD initiatives are disease models that have identified novel clinical and genetic markers of disease progression, the first two virtual PD research studies, the two largest smartphone studies in PD, the first longitudinal wearable sensor study for PD, and the only national randomized controlled trial of telemedicine for PD. The University's Goergen Data Science Institute and the University of Rochester's Clinical and Translational Science Institute will support the Administrative Core. In addition, a multidisciplinary network of leading investigators from top institutions, including Johns Hopkins, Aston University, and MIT, and innovative collaborators, such as 23andMe and Sage Bionetworks, will guide and assist with executing the UR-Udall Center's activities. The Administrative Core will conduct unparalleled outreach at the state, national, and global level. CHeT will utilize its statewide telemedicine network, which cares for hundreds in health professional shortage areas, to bring research opportunities to individuals in their communities. Working with the nation's largest advocacy organizations, the Core will enable national participation in research. Using its recently launched ParkinsonTV, the UR-Udall Center will reach 100,000's of individuals globally to educate them about PD and novel research. Finally, the Core will leverage the Department of Neurology's T32 fellowship program in experimental therapeutics, as well as extensive research and career development opportunities, to assemble and cross-train clinician-scientists and 10-20 computer scientists, mathematicians, and electrical engineers in PD research to create the first collaborative group of PD investigators with both clinical research and computational science expertise. This influx and development of scarce human capital will be one of the UR-Udall Center's many enduring and valuable contributions to the field.

总结 乌尔-尤德尔中心的行政核心将利用大学的现有资源， 罗切斯特的健康与技术中心（CHeT）。在过去的25年里，CHeT开创了多中心 这些研究在120项研究中招募了40，000人，这些研究导致了7项FDA批准的 治疗，包括四个PD。最近，CHeT已经使用技术来改变PD研究和护理。 在这些PD计划中，有一些疾病模型已经确定了新的临床和遗传标记， 疾病进展，前两项虚拟PD研究，两项最大的PD智能手机研究， 第一个纵向可穿戴传感器研究PD，和唯一的国家随机对照试验， PD的远程医疗 该大学的Goergen数据科学研究所和罗切斯特大学的临床和 翻译科学研究所将支持行政核心。此外，还建立了一个多学科网络， 来自顶级机构的领先研究人员，包括约翰霍普金斯，阿斯顿大学和麻省理工学院， 23andMe和Sage Bionetworks等合作者将指导和协助执行UR-Udall 中心的活动。 行政核心将在州、国家和全球层面开展无与伦比的外联活动。切特 将利用其全州范围的远程医疗网络，该网络照顾数百名卫生专业人员短缺的地区， 为社区中的个人带来研究机会。与全国最大的倡导组织合作 该核心将使各国能够参与研究。利用其最近推出的帕金森电视， UR-Udall中心将在全球范围内接触10万人，教育他们有关PD和新研究。 最后，核心将利用神经病学系的T32奖学金计划进行实验性研究。 治疗，以及广泛的研究和职业发展机会，组装和交叉培训 临床科学家和10-20名计算机科学家，数学家和PD研究中的电气工程师， 创建第一个具有临床研究和计算科学的PD研究人员合作小组 专业知识这种稀缺人力资本的流入和发展将是乌尔-尤德尔中心的许多 为该领域做出了持久而宝贵的贡献。