Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans

深部脑刺激增强人类记忆的机制

基本信息

  • 批准号:
    10242009
  • 负责人:
  • 金额:
    $ 58.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-06-01 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Loss of the ability to form new memories and retrieve old ones is one of the most dreaded afflictions of the human condition. It is present in various neurological disorders, including temporal lobe epilepsy, traumatic brain injury and is one of the first features of Alzheimer’s Disease (AD) affecting millions of people in the US and many more worldwide. Decades of research have established that declarative memory, the ability to remember recently experienced facts and events, depends on the hippocampus and associated structures in the medial temporal lobe (MTL), including the entorhinal cortex. Our laboratory has been a leader in single neuron physiology of the human MTL for last two decades and was the first group to publish findings using deep brain stimulation (DBS) of the entorhinal-hippocampal circuitry in humans to modulate human memory. Our approach is based on the unique opportunity to record activity of single neurons, neuronal assemblies and local field potentials (LFPs), as well as to apply deep brain stimulation of neural circuits in neurosurgical patients. These are patients with intractable epilepsy who have intracranial depth electrodes implanted in order to identify their seizure focus for possible surgical cure. Our initial findings showed dramatic spatial memory enhancement when DBS was applied to the entorhinal area during learning [1]. In the initial funding period of this project, we built on this success by testing DBS across a wide variety of hippocampal-dependent memory tasks and demonstrating that the critical predictor of whether stimulation would improve memory was the precise spatial targeting of the stimulating electrode to the white matter of the entorhinal area (angular bundle). In the renewed grant, we will further refine our modulation of the entorhinal–hippocampal circuitry by using microstimulation to more precisely identify the spatial and temporal features of applied DBS that lead to enhanced memory. Through simultaneous microstimulation and recording, the project will elucidate the complex relationship between single neuronal responses, LFP oscillations, and DBS that underlies memory enhancement. A primary objective will be to expand the investigation of DBS from encoding to the critical memory phases of consolidation and retrieval, across three memory tasks. Importantly, we will probe the effects of DBS on consolidation during sleep which provides an intriguing and feasible time window for potential clinical intervention. A critical component of our modulation will involve the use of novel closed-loop technology to provide stimulation coordinated in time with endogenous oscillations that have been shown to be critically important for encoding, retrieval, and for consolidation during sleep. The project aims at developing critical insights into the mechanisms of human memory and its enhancement through closed-loop DBS in humans, and thus may contribute significantly to the development of novel therapeutic approaches to human memory disorders.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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ITZHAK FRIED其他文献

ITZHAK FRIED的其他文献

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{{ truncateString('ITZHAK FRIED', 18)}}的其他基金

Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles
清醒/睡眠周期期间人类记忆的解码和选择性调制
  • 批准号:
    10472000
  • 财政年份:
    2021
  • 资助金额:
    $ 58.93万
  • 项目类别:
Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles
清醒/睡眠周期期间人类记忆的解码和选择性调制
  • 批准号:
    10289993
  • 财政年份:
    2021
  • 资助金额:
    $ 58.93万
  • 项目类别:
Memory consolidation during sleep studied by direct neuronal recording and stimulation inside human brain
通过人脑内的直接神经元记录和刺激研究睡眠期间的记忆巩固
  • 批准号:
    9791019
  • 财政年份:
    2018
  • 资助金额:
    $ 58.93万
  • 项目类别:
Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans
深部脑刺激增强人类记忆的机制
  • 批准号:
    9095458
  • 财政年份:
    2013
  • 资助金额:
    $ 58.93万
  • 项目类别:
Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans
深部脑刺激增强人类记忆的机制
  • 批准号:
    10002304
  • 财政年份:
    2013
  • 资助金额:
    $ 58.93万
  • 项目类别:
Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans
深部脑刺激增强人类记忆的机制
  • 批准号:
    9790983
  • 财政年份:
    2013
  • 资助金额:
    $ 58.93万
  • 项目类别:
Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans
深部脑刺激增强人类记忆的机制
  • 批准号:
    8850268
  • 财政年份:
    2013
  • 资助金额:
    $ 58.93万
  • 项目类别:
Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans
深部脑刺激增强人类记忆的机制
  • 批准号:
    8563354
  • 财政年份:
    2013
  • 资助金额:
    $ 58.93万
  • 项目类别:
Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans
深部脑刺激增强人类记忆的机制
  • 批准号:
    8664952
  • 财政年份:
    2013
  • 资助金额:
    $ 58.93万
  • 项目类别:
Neuronal Correlates of Memory in the Human Temporal Lobe
人类颞叶记忆的神经元相关性
  • 批准号:
    6383575
  • 财政年份:
    1996
  • 资助金额:
    $ 58.93万
  • 项目类别:
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