Ubiquitin signaling in epigenetic regulation of neuronal development
神经元发育表观遗传调控中的泛素信号传导
基本信息
- 批准号:10251284
- 负责人:
- 金额:$ 16.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-20 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAmishAnatomyArchitectureBehavioralBehavioral AssayBindingBiochemicalBrainBrain DiseasesCell CycleCell Cycle ProgressionChIP-seqChargeChromatinClinical Investigator AwardCollaborationsComplexCore FacilityCullin ProteinsDataDevelopmentDevelopment PlansDevelopmental Delay DisordersDevelopmental ProcessDiseaseDoctor of PhilosophyEnrollmentEpigenetic ProcessExhibitsFellowshipFollow-Up StudiesFoundationsGene ExpressionGene Expression RegulationGenesGeneticGenetic EngineeringGenetic TranscriptionGenomeGenomic approachGoalsHereditary DiseaseHeterochromatinHistonesHoloenzymesImageImmunologyInformaticsInheritedInvestigationK-Series Research Career ProgramsKnock-outLaboratoriesLeadLysineMassive Parallel SequencingMendelian disorderMentorsMethodsMichiganMicroscopyMitosisMitoticMitotic ChromosomeMolecularMorphogenesisMusMutant Strains MiceMutationNeurodevelopmental DisorderNeuronal DifferentiationNeuronsNeurosciencesNuclearPathogenesisPathologyPathway interactionsPatientsPhenotypePhysiciansPlayPrincipal InvestigatorProcessProtein phosphataseRNA InterferenceResearchResearch PersonnelResidenciesRoleScientistSerineSignal PathwaySignal TransductionStructureSystemTestingTrainingTraining ProgramsTranscriptUbiquitinUbiquitinationUniversitiesWashingtonanaphase-promoting complexcareercareer developmentchromatin immunoprecipitationcohortdevelopmental neurobiologydifferential expressiondisease-causing mutationepigenetic regulationexperienceexperimental studyheterochromatin-specific nonhistone chromosomal protein HP-1improvedin vivoinsightknock-downmedical schoolsmind controlmulticatalytic endopeptidase complexmutantmutant mouse modelneurodevelopmentneuron developmentneuropathologynext generation sequencingnovelnull mutationoverexpressionpreventprobandprogenitorprogramsquantitative imagingsurfactantsynaptogenesistranscriptome sequencingubiquitin-protein ligase
项目摘要
Project Summary/Abstract
This proposal describes the five-year career development plan for Principal Investigator Cole J. Ferguson,
MD, PhD, with the goal of preparing him for an independent research career as an academic physician-
scientist. Dr. Ferguson enrolled in the Physician-Scientist Training Program within the Pathology &
Immunology Department at Washington University after completing the MD/PhD program at the University of
Michigan. Following the Anatomic and Neuropathology residency-fellowship, Dr. Ferguson began working in
the laboratory of Azad Bonni, where he studies the ubiquitin-proteasome system (UPS) in inherited
neurodevelopmental disorders. The long-term goal of Dr. Ferguson's research is to improve the understanding
of the molecular and cellular pathogenesis of this diverse class of disorders. For this proposal, he has
genetically engineered a mutant mouse to study a novel inherited neurodevelopmental disorder caused by
mutation in a major E3 ubiquitin ligase complex. While investigating brain development in mutant mice, he
uncovered a major mechanism of epigenetic regulation during the transition from dividing progenitors to
functional neurons. Aim 1 will characterize the molecular cascade that underlies aberrant chromatin
maturation, while Aim 2 will explore the consequences on gene expression in the developing versus mature
brain. In the course of this project, Dr. Ferguson will become an expert in imaging, biochemical and genomics
approaches to study epigenetics in the brain. This project has the potential for significant expansion and is an
outstanding scientific foundation for the start of Dr. Ferguson's independent laboratory.
Washington University is the ideal setting for Dr. Ferguson to achieve these aims. His mentor Dr. Azad
Bonni is Chair of the Neuroscience Department and a preeminent molecular neuroscientist who has pioneered
the study of the UPS in brain development. Dr. Bonni has an outstanding record of training independent
investigators in his laboratory. In addition, the Department of Neuroscience has expanded upon its tradition of
collaboration and cutting-edge experimentation across both molecular and systems neuroscience. This
proposal will make extensive use of the School of Medicine's world-class core facilities in microscopy and next-
generation sequencing. The expertise of Dr. Ferguson's esteemed scientific advisory panel encompasses all
aspects of this proposal, including neurodevelopmental disorders, epigenetic regulation, and ubiquitin signaling
in brain development. The Pathology Physician-Scientist Training Program committee will play an active role in
Dr. Ferguson's career development, and this program has an outstanding record of transitioning trainees into
independent investigators through the K08 mechanism. In short, this proposal will make progress on several
important aspects of epigenetic regulation in developmental neurobiology, while providing invaluable technical
training and career development to a highly promising physician-scientist.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Cole John Ferguson其他文献
Cole John Ferguson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Cole John Ferguson', 18)}}的其他基金
Ubiquitin signaling in epigenetic regulation of neuronal development
神经元发育表观遗传调控中的泛素信号传导
- 批准号:
10478055 - 财政年份:2021
- 资助金额:
$ 16.4万 - 项目类别:
Ubiquitin signaling in epigenetic regulation of neuronal development
神经元发育表观遗传调控中的泛素信号传导
- 批准号:
10375983 - 财政年份:2021
- 资助金额:
$ 16.4万 - 项目类别:
Ubiquitin signaling in epigenetic regulation of neuronal development
神经元发育表观遗传调控中的泛素信号传导
- 批准号:
10683762 - 财政年份:2021
- 资助金额:
$ 16.4万 - 项目类别:
Ubiquitin signaling in epigenetic regulation of neuronal development
神经元发育表观遗传调控中的泛素信号传导
- 批准号:
10015330 - 财政年份:2019
- 资助金额:
$ 16.4万 - 项目类别:
Ubiquitin signaling in epigenetic regulation of neuronal development
神经元发育表观遗传调控中的泛素信号传导
- 批准号:
9806402 - 财政年份:2019
- 资助金额:
$ 16.4万 - 项目类别:
相似海外基金
Protective Genetic Variants for Alzheimer Disease in the Amish - RENEWAL
阿米什人阿尔茨海默病的保护性遗传变异 - RENEWAL
- 批准号:
10448612 - 财政年份:2022
- 资助金额:
$ 16.4万 - 项目类别:
Protective Genetic Variants for Alzheimer Disease in the Amish - RENEWAL
阿米什人阿尔茨海默病的保护性遗传变异 - RENEWAL
- 批准号:
10689703 - 财政年份:2022
- 资助金额:
$ 16.4万 - 项目类别:
SHWITZER: Amish Shwitzer as a mixed language with closely related parents
Shwitzer:Amish Shwitzer 作为一种与父母密切相关的混合语言
- 批准号:
403803976 - 财政年份:2018
- 资助金额:
$ 16.4万 - 项目类别:
Research Grants
Protective Genetic Variants for Alzheimer Disease in the Amish
阿米什人阿尔茨海默病的保护性遗传变异
- 批准号:
9898659 - 财政年份:2017
- 资助金额:
$ 16.4万 - 项目类别:
Protective Genetic Variants for Alzheimer Disease in the Amish
阿米什人阿尔茨海默病的保护性遗传变异
- 批准号:
9439190 - 财政年份:2017
- 资助金额:
$ 16.4万 - 项目类别:
Children's literature with Amish themes:Its analysis and reception
阿米什主题儿童文学:分析与接受
- 批准号:
16K02486 - 财政年份:2016
- 资助金额:
$ 16.4万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The relationship between Amish religious identity and consumer culture
阿米什人宗教认同与消费文化的关系
- 批准号:
15K01863 - 财政年份:2015
- 资助金额:
$ 16.4万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
FAST-PS New Study Task - "Verification of mGluR5 Overexpression in Old Amish Mutation Carriers
FAST-PS新研究任务——“古阿米什突变携带者中mGluR5过表达的验证”
- 批准号:
9038958 - 财政年份:2015
- 资助金额:
$ 16.4万 - 项目类别:
IGF::OT::IGF FAST-PS New Study Task - "Verification of mGluR5 Overexpression in Old Amish Mutation Carriers"
IGF::OT::IGF FAST-PS 新研究任务 - “古阿米什突变携带者中 mGluR5 过表达的验证”
- 批准号:
8947312 - 财政年份:2014
- 资助金额:
$ 16.4万 - 项目类别: