MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies
iGeneTRAiN 研究中的 MHC 和 KIR 测序及关联分析
基本信息
- 批准号:10251946
- 负责人:
- 金额:$ 48.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-02 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAlgorithmsAllograftingAminesAmino Acid MotifsAmino AcidsAntigensCategoriesCollaborationsComputerized Medical RecordDNADataData SetDatabasesElectrostaticsEpitopesFailureGenerationsGeneticGenetic PolymorphismGenetic ResearchGenomic approachGenotypeHaplotypesHeartHeart TransplantationIndividualInformed ConsentInternationalKidneyKidney TransplantationLifeLigandsLinkage DisequilibriumLungLung TransplantationMeasuresMethodsNatural Killer CellsNomenclatureOrganOrgan TransplantationOutcomePathway interactionsPatientsPearPeptidesPhasePhenotypePilot ProjectsPlayPopulationProceduresRegistriesResolutionRetrospective StudiesRoleSNP genotypingSalvelinusSamplingSavingsSerologySolidStructureSurfaceTrainingTranslational ResearchTransplantationVariantViralanalysis pipelinebaseclinically relevantcohortdelayed graft functionend stage diseaseexome sequencinggenetic architecturegenetic associationgenetic variantgenome wide association studygenome-widegenomic datahematopoietic cell transplantationhuman leukocyte antigen testinghuman subjectimprovedinnovationliver transplantationnovelrisk stratificationscaffoldscale upthree-dimensional modeling
项目摘要
PROJECT SUMMARY
HLA donor-recipient (D-R) matching is critical for graft outcomes following Kidney, Heart, Lung
and hematopoietic cell transplantation. Genetic association studies in large well-characterized
transplant cohorts are lacking and there is a clear need to characterize how MHC and KIR
genetic variants underpin transplantation outcomes. The International Genetics & Translational
Research in Transplantation Network (iGeneTRAiN) was formed to increase the understanding
of the genetic architecture of transplant outcomes, by bringing together transplantation studies
with genome-wide association study (GWAS) datasets from >52,600 recipients/donors across
well-curated heart, kidney, liver and lung transplant phenotype datasets. This constitutes the
largest solid-organ transplant consortium ever assembled. A strategic Pharma collaboration
where we sequence key HLA Class I and II in the majority of iGeneTRAiN studies, and
additional MHC/KIR regions in subsets of studies, is facilitating ample statistical power to
assess association studies of HLA and KIR with key transplant-related outcomes. A large
portion of the iGeneTRAiN database is derived from non-European ancestry samples, which
greatly addresses the lack of adequate MHC/KIR genetic data in these populations.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KRZYSZTOF KIRYLUK其他文献
KRZYSZTOF KIRYLUK的其他文献
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{{ truncateString('KRZYSZTOF KIRYLUK', 18)}}的其他基金
Non-APOL1 genetic factors and kidney transplant outcomes
非 APOL1 遗传因素与肾移植结果
- 批准号:
10717171 - 财政年份:2023
- 资助金额:
$ 48.54万 - 项目类别:
MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies
iGeneTRAiN 研究中的 MHC 和 KIR 测序及关联分析
- 批准号:
10438855 - 财政年份:2020
- 资助金额:
$ 48.54万 - 项目类别:
MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies
iGeneTRAiN 研究中的 MHC 和 KIR 测序及关联分析
- 批准号:
10020606 - 财政年份:2020
- 资助金额:
$ 48.54万 - 项目类别:
Big Data Methods for Comprehensive Similarity based Risk Prediction
基于大数据的综合相似性风险预测方法
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10551349 - 财政年份:2019
- 资助金额:
$ 48.54万 - 项目类别:
Big Data Methods for Comprehensive Similarity based Risk Prediction
基于大数据的综合相似性风险预测方法
- 批准号:
10323033 - 财政年份:2019
- 资助金额:
$ 48.54万 - 项目类别:
Big Data Methods for Comprehensive Similarity based Risk Prediction
基于大数据的综合相似性风险预测方法
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10087958 - 财政年份:2019
- 资助金额:
$ 48.54万 - 项目类别:
Genetics of IgA nephropathy by integrative network-based association studies
基于综合网络关联研究的 IgA 肾病遗传学
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9258422 - 财政年份:2015
- 资助金额:
$ 48.54万 - 项目类别:
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