MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies

iGeneTRAiN 研究中的 MHC 和 KIR 测序及关联分析

基本信息

  • 批准号:
    10251946
  • 负责人:
  • 金额:
    $ 48.54万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-02 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY HLA donor-recipient (D-R) matching is critical for graft outcomes following Kidney, Heart, Lung and hematopoietic cell transplantation. Genetic association studies in large well-characterized transplant cohorts are lacking and there is a clear need to characterize how MHC and KIR genetic variants underpin transplantation outcomes. The International Genetics & Translational Research in Transplantation Network (iGeneTRAiN) was formed to increase the understanding of the genetic architecture of transplant outcomes, by bringing together transplantation studies with genome-wide association study (GWAS) datasets from >52,600 recipients/donors across well-curated heart, kidney, liver and lung transplant phenotype datasets. This constitutes the largest solid-organ transplant consortium ever assembled. A strategic Pharma collaboration where we sequence key HLA Class I and II in the majority of iGeneTRAiN studies, and additional MHC/KIR regions in subsets of studies, is facilitating ample statistical power to assess association studies of HLA and KIR with key transplant-related outcomes. A large portion of the iGeneTRAiN database is derived from non-European ancestry samples, which greatly addresses the lack of adequate MHC/KIR genetic data in these populations.
项目总结

项目成果

期刊论文数量(0)
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KRZYSZTOF KIRYLUK其他文献

KRZYSZTOF KIRYLUK的其他文献

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{{ truncateString('KRZYSZTOF KIRYLUK', 18)}}的其他基金

Non-APOL1 genetic factors and kidney transplant outcomes
非 APOL1 遗传因素与肾移植结果
  • 批准号:
    10717171
  • 财政年份:
    2023
  • 资助金额:
    $ 48.54万
  • 项目类别:
Multi-Omics for Chronic Kidney Disease
慢性肾脏病的多组学
  • 批准号:
    10744557
  • 财政年份:
    2023
  • 资助金额:
    $ 48.54万
  • 项目类别:
MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies
iGeneTRAiN 研究中的 MHC 和 KIR 测序及关联分析
  • 批准号:
    10438855
  • 财政年份:
    2020
  • 资助金额:
    $ 48.54万
  • 项目类别:
MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies
iGeneTRAiN 研究中的 MHC 和 KIR 测序及关联分析
  • 批准号:
    10020606
  • 财政年份:
    2020
  • 资助金额:
    $ 48.54万
  • 项目类别:
Big Data Methods for Comprehensive Similarity based Risk Prediction
基于大数据的综合相似性风险预测方法
  • 批准号:
    10551349
  • 财政年份:
    2019
  • 资助金额:
    $ 48.54万
  • 项目类别:
Big Data Methods for Comprehensive Similarity based Risk Prediction
基于大数据的综合相似性风险预测方法
  • 批准号:
    10323033
  • 财政年份:
    2019
  • 资助金额:
    $ 48.54万
  • 项目类别:
Big Data Methods for Comprehensive Similarity based Risk Prediction
基于大数据的综合相似性风险预测方法
  • 批准号:
    10087958
  • 财政年份:
    2019
  • 资助金额:
    $ 48.54万
  • 项目类别:
Genomics of glomerular disease
肾小球疾病的基因组学
  • 批准号:
    10203943
  • 财政年份:
    2018
  • 资助金额:
    $ 48.54万
  • 项目类别:
Genomics of glomerular disease
肾小球疾病的基因组学
  • 批准号:
    10413152
  • 财政年份:
    2018
  • 资助金额:
    $ 48.54万
  • 项目类别:
Genetics of IgA nephropathy by integrative network-based association studies
基于综合网络关联研究的 IgA 肾病遗传学
  • 批准号:
    9258422
  • 财政年份:
    2015
  • 资助金额:
    $ 48.54万
  • 项目类别:

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