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MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies

iGeneTRAiN 研究中的 MHC 和 KIR 测序及关联分析

基本信息

批准号：
10251946
负责人：
KRZYSZTOF KIRYLUK
金额：
$ 48.54万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-02 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10251946
关键词：
Acute Address Algorithms Allografting Amines Amino Acid Motifs Amino Acids Antigens Categories Collaborations Computerized Medical Record DNA Data Data Set Databases Electrostatics Epitopes Failure Generations Genetic Genetic Polymorphism Genetic Research Genomic approach Genotype Haplotypes Heart Heart Transplantation Individual Informed Consent International Kidney Kidney Transplantation Life Ligands Linkage Disequilibrium Lung Lung Transplantation Measures Methods Natural Killer Cells Nomenclature Organ Organ Transplantation Outcome Pathway interactions Patients Pear Peptides Phase Phenotype Pilot Projects Play Population Procedures Registries Resolution Retrospective Studies Role SNP genotyping Salvelinus Sampling Savings Serology Solid Structure Surface Training Translational Research Transplantation Variant Viral analysis pipeline base clinically relevant cohort delayed graft function end stage disease exome sequencing genetic architecture genetic association genetic variant genome wide association study genome-wide genomic data hematopoietic cell transplantation human leukocyte antigen testing human subject improved innovation liver transplantation novel risk stratification scaffold scale up three-dimensional modeling

项目摘要

PROJECT SUMMARY HLA donor-recipient (D-R) matching is critical for graft outcomes following Kidney, Heart, Lung and hematopoietic cell transplantation. Genetic association studies in large well-characterized transplant cohorts are lacking and there is a clear need to characterize how MHC and KIR genetic variants underpin transplantation outcomes. The International Genetics & Translational Research in Transplantation Network (iGeneTRAiN) was formed to increase the understanding of the genetic architecture of transplant outcomes, by bringing together transplantation studies with genome-wide association study (GWAS) datasets from >52,600 recipients/donors across well-curated heart, kidney, liver and lung transplant phenotype datasets. This constitutes the largest solid-organ transplant consortium ever assembled. A strategic Pharma collaboration where we sequence key HLA Class I and II in the majority of iGeneTRAiN studies, and additional MHC/KIR regions in subsets of studies, is facilitating ample statistical power to assess association studies of HLA and KIR with key transplant-related outcomes. A large portion of the iGeneTRAiN database is derived from non-European ancestry samples, which greatly addresses the lack of adequate MHC/KIR genetic data in these populations.

项目总结