Mentored Patient Oriented Research in ARDS and Critical Illness Outcomes

指导 ARDS 和危重疾病结果中以患者为导向的研究

• 批准号: 10249623
• 负责人: Catherine Lee Hough
• 金额: $ 11.86万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10249623
• 关键词: Acute; Admission activity; Adult Respiratory Distress Syndrome; Affect; Area; Award; Biology; Cessation of life; Chest; Chronic; Clinical; Clinical Data; Clinical Trials; Communities; Conduct Clinical Trials; Critical Care; Critical Illness; Data; Development; Development Plans; Disease; Distress; Educational workshop; Electrophysiology (science); Enrollment; Environment; Epidemiologic Methods; Etiology; Faculty; Family; Funding; Future; Goals; Health; Health Services Research; Health Status; Hospital Mortality; Image; Impairment; Infrastructure; Injury; Intervention; Intervention Studies; Knowledge; Leadership; Learning; Lung; Measures; Mechanical ventilation; Medicine; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Morbidity - disease rate; Muscle; Muscle function; National Heart, Lung, and Blood Institute; Observational Study; Online Systems; Outcome; Outcome Study; Patient Education; Patient-Focused Outcomes; Patients; Personal Satisfaction; Persons; Phenotype; Physical Function; Play; Postdoctoral Fellow; Principal Investigator; Prospective cohort; Proxy; Recovery; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Scanning; Science; Scientist; Sleep; Structure; Survivors; Techniques; Time; Training; Universities; Washington; Work; X-Ray Computed Tomography; abdominal CT; career; career development; clinical care; clinical epidemiology; clinical practice; cohort; comorbidity; design; disability; disability burden; functional disability; health care service utilization; health related quality of life; improved; improved outcome; innovation; mentoring community; mindfulness intervention; mortality; muscle form; muscle strength; neuromuscular; novel; outcome prediction; patient oriented; patient oriented research; programs; prospective; randomized trial; reduced muscle mass; research and development; sarcopenia; skills; student mentoring; success; successful intervention

PROJECT SUMMARY/ABSTRACT The goal of this Midcareer Investigator Award in Patient Oriented Research is to provide key mentorship, resources and protected time to strengthen Dr. Catherine Hough's success in mentoring students, post- doctoral fellows and junior faculty in the science of patient-centered outcomes after the acute illness and injury, with a focus on the acute respiratory distress syndrome and critical illness. Although hospital mortality after critical illness has improved significantly over the past decades, there is increasing recognition that recovery is incomplete, with a substantial burden of disability and impairments in function and health-related quality of life among ICU survivors. Interventions to improve these patient-centered outcomes have been largely unsuccessful, and understanding of the mechanisms of post-ICU impairments remains quite limited. Recently, there has been increased recognition that pre-morbid health and disability are significant contributors to post- ICU impairment and to the heterogeneous trajectories of recovery, but research and clinical practice have been stalled by the difficulty of assessing pre-morbid factors at the time of ICU admission. Moving the field forward will require innovative approaches to phenotyping patients using clinical data and techniques from clinical epidemiology and health services research. Dr. Hough is an ideal candidate to provide mentorship in this area. She is a mid-career investigator with expertise in observational and interventional studies of outcomes after ARDS and critical illness, and she has a strong and growing track record in successful mentorship in patient- oriented research as well as a strong existing research program. In this award, Dr. Hough will enhance and advance her career in three ways. She will participate in structured activities to develop her mentoring skills, including one-on-one sessions with Dr. Randy Curtis, local in-person workshops and national web-based programs. She will gain content knowledge on muscle biology, use of computed tomography images in assessing muscle mass and quality. Additionally, she will work with methods experts to learn to incorporate clinical and administrative data of co-morbidity and health-care utilization into developing phenotypes of premorbid disease that predict disability and recovery. The scientific goal of this project is to investigate the relationship between premorbid muscle mass and quality, assessed via analysis of existing computed tomography scans, and short and long-term outcomes after critical illness, including muscle strength, function and disability. This project will leverage two ongoing R01-funded prospective cohorts for which Dr. Hough is a PI which contain detailed assessment of co-morbidities and pre-morbid health care utilization, prospective assessments of muscle strength and function during and after critical illness, and will create new opportunities for mentored research. Dr. Hough's career development and scientific aims will provide an outstanding environment for training of patient-oriented researchers focused on improving outcomes after critical illness.

项目摘要/摘要 这个以患者为中心的研究的职业生涯中期奖的目标是提供关键的指导， 资源和受保护的时间，以加强凯瑟琳·霍夫博士在指导学生方面的成功，后 以患者为中心研究急性疾病和损伤后转归的博士生和初级教员， 重点关注急性呼吸窘迫综合征和危重疾病。虽然住院后的死亡率 在过去的几十年里，危重疾病有了显著的改善，人们越来越认识到，康复是 不完整，有相当大的残疾负担，功能和与健康相关的生活质量受损 在重症监护室的幸存者中。改善这些以患者为中心的结果的干预措施在很大程度上是 没有成功，对ICU后损害机制的了解仍然相当有限。最近， 人们越来越多地认识到，患病前的健康和残疾是导致后抑郁的重要因素 ICU损伤和恢复的异质性轨迹，但研究和临床实践一直 在ICU入院时，由于难以评估发病前因素而停滞不前。推动该领域向前发展 将需要使用临床数据和临床技术对患者进行表型鉴定的创新方法 流行病学和卫生服务研究。霍夫博士是在这一领域提供指导的理想人选。 她是一名职业生涯中期的调查员，在观察和干预研究结果方面具有专长 ARDS和危重疾病，她在患者成功指导方面有很强的和不断增长的记录- 以研究为导向，以及强大的现有研究计划。在这个奖项中，霍夫博士将加强和 从三个方面推进她的事业。她将参加有组织的活动，以发展她的指导技能， 包括与兰迪·柯蒂斯博士的一对一会议、地方面对面研讨会和基于网络的国家 程序。她将获得肌肉生物学的内容知识，使用计算机断层扫描图像在 评估肌肉质量和质量。此外，她将与方法专家合作，学习如何将 共病和保健利用对发展表型的临床和管理数据 预示残疾和康复的病前疾病。这个项目的科学目标是调查 病前肌肉质量和质量之间的关系，通过分析现有的计算机进行评估 断层扫描，以及危重疾病后的短期和长期结果，包括肌肉力量、功能 和残疾。该项目将利用两个正在进行的R01资助的预期队列，Hough博士是 PI包含对合并症和发病前医疗保健利用的详细评估，前瞻性 在危重疾病期间和之后评估肌肉力量和功能，并将创造新的机会 进行有指导的研究。霍夫博士的职业发展和科学目标将为 为以患者为中心的研究人员提供培训环境，重点是改善危重疾病后的预后。