Prospective memory impairment in Parkinson disease-related cognitive decline: Intervention and mechanisms
帕金森病相关认知能力下降的前瞻性记忆障碍:干预措施和机制
基本信息
- 批准号:10260416
- 负责人:
- 金额:$ 51.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-15 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAlzheimer&aposs disease related dementiaAttentionAttenuatedBehavior TherapyBehavioralBehavioral MechanismsBiologicalBrainBrain InjuriesClinicalCognitionCognitiveCognitive deficitsDataDementiaDopamineEducational InterventionEducational process of instructingEmploymentEvaluationExpectancyFosteringFunctional disorderFutureGoalsHealth Care CostsHealth behaviorImpaired cognitionImpairmentIndependent LivingIntentionInterventionIntervention StudiesLaboratoriesLateralLifeLongitudinal cohortMagnetic Resonance ImagingMedicalMemoryMemory impairmentMental DepressionMonitorMotivationMotorNeurologicOperative Surgical ProceduresParentsParkinson DiseaseParkinson&aposs DementiaParticipantPatternPerformancePharmaceutical PreparationsPharmacological TreatmentPopulationPopulations at RiskPrediction of Response to TherapyProcessPsychological TransferQuality of lifeRandomizedRandomized Controlled TrialsRegression AnalysisReportingResearchResearch PersonnelResearch PriorityRestRetrievalRiskSingle-Blind StudyStandardizationStrokeTestingTrainingTraining ProgramsWorkbehavior testcognitive functioncognitive impairment in Parkinson&aposscognitive processcognitive rehabilitationcognitive taskcomputerizeddaily functioningdata infrastructuredesigndisabilityefficacy testingexecutive functionfunctional declinefunctional disabilityfunctional outcomesimprovedinformantmild cognitive impairmentmortalitymultilevel analysisneural correlateneurobiological mechanismneuroimagingneuromechanismnovelpredicting responseprimary endpointprogrammed cell death protein 1prospective memoryrelating to nervous systemrepetitive task practiceresponsesecondary endpointsocial relationshipstreatment responsetrial comparing
项目摘要
Erin R. Foster
R01 AG065214-01A1
Prospective memory impairment in Parkinson disease-related cognitive decline: Intervention and mechanisms
PROJECT SUMMARY/ABSTRACT
Parkinson disease dementia (PDD) – one of the Alzheimer’s Disease Related Dementias (ADRD) – is associated with increased disability, mortality and healthcare costs among people with PD. The long term goal of this research is to reduce disability and delay the onset of the ADRD PDD by enabling people at risk for PDD to cope with cognitive decline to maintain daily function. Existing medical (e.g. surgical, pharmacological) treatments for PD do not prevent or treat cognitive impairment, so behavioral interventions that mitigate its negative functional consequences and potentially delay or slow PDD are a top research priority. Unfortunately, the widely-used process training approach to cognitive intervention (repetitive practice of tasks designed to challenge and improve particular cognitive functions) has been unsuccessful in improving daily function and quality of life in this population. To overcome this limitation, the investigators take a strategy training approach, teaching targeted strategies that people can use in their everyday lives to circumvent cognitive deficits and accomplish daily tasks. Strategy training is a practice standard for cognitive rehabilitation in brain injury and stroke, but its application to PDD is novel. Moreover, the strategy training intervention developed for this study explicitly focuses on generalization of training to daily function, an aspect that is critically lacking from many typical strategy training approaches and from PD-related cognitive intervention research to date. This project addresses prospective memory, or the ability to remember to execute delayed intentions at the appropriate moment in the future. Good prospective memory is essential for independent living (e.g. paying bills, turning the stove off), employment, social relationships, and compliance with important health behaviors (e.g. taking medications). People at risk for PDD have prospective memory deficits that relate to worse daily function and quality of life. Therefore, prospective memory impairment is a relevant cognitive problem to address in this population. The primary objective of the current project is to determine the efficacy of mechanistically-targeted strategy training on prospective memory among people at risk for PDD (those with PD-related mild cognitive impairment; PD-MCI). It is a single-blind randomized controlled trial comparing the effects of strategy training to the traditional process training approach on objective laboratory prospective memory performance (Aim 1) and reported everyday prospective memory function (Aim 2). Additional objectives are to investigate neural mechanisms of prospective memory impairment in PD-MCI (Aim 3) and neural and behavioral predictors of prospective memory training response (Aim 4). This project leverages participants, data and infrastructure from an existing longitudinal cohort of PD, PD-MCI, PDD and control participants to evaluate short-term and long-term training effects, neurobiological mechanisms, and predictors of treatment response. This work will meet the pressing need for effective cognitive interventions that delay functional impairment associated with the ADRD PDD and will positively impact function and quality of life in this population.
埃林河福斯特
R01 AG065214-01A1
帕金森病相关认知功能减退的前瞻性记忆损害:干预和机制
项目总结/摘要
帕金森病痴呆(PDD)-阿尔茨海默病相关痴呆(ADRD)之一-与PD患者的残疾,死亡率和医疗费用增加有关。本研究的长期目标是通过使PDD风险人群能够科普认知能力下降以维持日常功能,从而减少残疾并延迟ADRD PDD的发作。PD的现有医学(例如手术,药物)治疗不能预防或治疗认知障碍,因此减轻其负面功能后果并可能延迟或减缓PDD的行为干预是研究的首要任务。不幸的是,广泛使用的认知干预过程训练方法(旨在挑战和改善特定认知功能的任务的重复练习)在改善这一人群的日常功能和生活质量方面并不成功。为了克服这一局限性,研究人员采取了一种策略训练方法,教授人们可以在日常生活中使用的有针对性的策略,以规避认知缺陷并完成日常任务。策略训练是脑损伤和中风认知康复的实践标准,但其应用于PDD是新的。此外,为这项研究开发的策略训练干预明确侧重于将训练推广到日常功能,这是许多典型策略训练方法和迄今为止与PD相关的认知干预研究严重缺乏的方面。这个项目解决了前瞻性记忆,或记住在未来适当时刻执行延迟意图的能力。良好的前瞻性记忆对于独立生活(例如支付账单,关闭炉子),就业,社会关系和遵守重要的健康行为(例如服用药物)至关重要。有PDD风险的人有前瞻性记忆缺陷,这与日常功能和生活质量较差有关。因此,前瞻性记忆障碍是一个相关的认知问题,以解决在这一人群。本项目的主要目的是确定机制定向策略训练对PDD风险人群(PD相关轻度认知障碍; PD-MCI)前瞻记忆的有效性。这是一项单盲随机对照试验,比较策略训练与传统过程训练方法对客观实验室前瞻记忆表现(Aim 1)和报告的日常前瞻记忆功能(Aim 2)的影响。其他目的是研究PD-MCI前瞻性记忆障碍的神经机制(目的3)和前瞻性记忆训练反应的神经和行为预测因子(目的4)。该项目利用来自PD、PD-MCI、PDD和对照参与者的现有纵向队列的参与者、数据和基础设施来评估短期和长期训练效果、神经生物学机制和治疗反应的预测因素。这项工作将满足有效的认知干预的迫切需要,延迟与ADRD PDD相关的功能障碍,并将积极影响该人群的功能和生活质量。
项目成果
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ERIN R FOSTER其他文献
ERIN R FOSTER的其他文献
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{{ truncateString('ERIN R FOSTER', 18)}}的其他基金
Prospective memory impairment in Parkinson disease-related cognitive decline: Intervention and mechanisms
帕金森病相关认知能力下降的前瞻性记忆障碍:干预措施和机制
- 批准号:
10661005 - 财政年份:2020
- 资助金额:
$ 51.19万 - 项目类别:
Prospective memory impairment in Parkinson disease-related cognitive decline: Intervention and mechanisms
帕金森病相关认知能力下降的前瞻性记忆障碍:干预措施和机制
- 批准号:
10404667 - 财政年份:2020
- 资助金额:
$ 51.19万 - 项目类别:
Strategy-based cognitive intervention for Parkinson disease: A pilot randomizedcontrolled trial
基于策略的帕金森病认知干预:一项随机对照试验
- 批准号:
10444191 - 财政年份:2019
- 资助金额:
$ 51.19万 - 项目类别:
COGNITIVE REHABILITATION FOR EVERYDAY EXECUTIVE DYSFUNCTION IN PARKINSON DISEASE
帕金森病日常执行功能障碍的认知康复
- 批准号:
8412993 - 财政年份:2012
- 资助金额:
$ 51.19万 - 项目类别:
COGNITIVE REHABILITATION FOR EVERYDAY EXECUTIVE DYSFUNCTION IN PARKINSON DISEASE
帕金森病日常执行功能障碍的认知康复
- 批准号:
8224883 - 财政年份:2012
- 资助金额:
$ 51.19万 - 项目类别:
COGNITIVE REHABILITATION FOR EVERYDAY EXECUTIVE DYSFUNCTION IN PARKINSON DISEASE
帕金森病日常执行功能障碍的认知康复
- 批准号:
8600303 - 财政年份:2012
- 资助金额:
$ 51.19万 - 项目类别: