Clinical Research & Informatics Core

临床研究

• 批准号: 10260487
• 负责人: Arlene A Stecenko
• 金额: $ 12.96万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260487
• 关键词: Accreditation; Address; Affect; Behavior; Behavioral; Biological Specimen Banks; Biometry; Bone Diseases; Caring; Child; Clinical; Clinical Data; Clinical Informatics; Clinical Research; Collaborations; Computers; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Data; Data Analyses; Data Management Resources; Data Scientist; Databases; Development; Diabetes Mellitus; Digestive System Disorders; Endocrine System Diseases; Engineering; Ensure; Experimental Designs; Foundations; Gastrointestinal Diseases; Glean; Goals; Individual; Institution; Laboratories; Laboratory Research; Life Style; Liver diseases; Methodology; Mission; Molecular; National Institute of Diabetes and Digestive and Kidney Diseases; Newborn Infant; Nutritional status; Outcome; Participant; Pharmaceutical Preparations; Physiological; Population; Pulmonary Cystic Fibrosis; Quality of life; Research; Research Design; Research Personnel; Resources; Retrieval; Secure; Sleep; Statistical Data Interpretation; Statistical Methods; Translational Research; Translations; Universities; base; cloud based; comorbidity; computer infrastructure; cystic fibrosis patients; cystic fibrosis related diabetes; data access; data integration; data management; data quality; data repository; data sharing; data warehouse; design; diet and exercise; gastrointestinal; human old age (65+); human subject; improved; innovation; multidisciplinary; multiple omics; nutrition; patient registry; preservation; programs; relational database; repository; research study; sound; tool; translational study

PROJECT SUMMARY – Core 4: Clinical Research and Informatics Core The Clinical Research and Informatics Core (CRIC) will provide a comprehensive, multi- disciplinary resource for the design and analysis of CF-related clinical and translational research studies focused on diabetes, other endocrine disorders, digestive and hepatic disorders, nutrition, and lifestyle behaviors. The CRIC will allow formalized, ongoing and collaborative relationships between CF investigators and provide an outstanding team of biostatisticians, data scientists, clinicians, and database engineers to assist investigators in utilizing appropriate and innovative experimental approaches and statistical methodology. This core will serve as a focal point from which investigators draw statistical and clinical expertise for planning, management, and analysis for their studies. The two major goals of this core will be: (1) to develop a mechanism for scientific oversight, including support for clinical and statistical expertise, and (2) to develop a secure, HIPPA compliant, cloud-based “Georgia CF Data Warehouse” that will serve as a data repository for CF-related clinical and laboratory data gathered from our 891 CF patients (701 in the Emory+Children’s program in Atlanta, 190 in the program at Augusta University).

项目概要-核心4：临床研究和信息学核心 临床研究和信息学核心（CRIC）将提供一个全面的，多方面的， CF相关临床和转化研究的设计和分析的学科资源 研究集中在糖尿病、其他内分泌失调、消化和肝脏失调、营养、 和生活方式行为。审评委将允许建立正式、持续和协作的关系 CF研究人员之间的合作，并提供一个优秀的生物统计学家，数据科学家， 临床医生和数据库工程师，以协助研究人员利用适当的和创新的 实验方法和统计方法。这一核心将作为一个焦点， 研究者从统计学和临床专业知识中获得计划、管理和分析的经验 以供他们学习。该核心的两大目标是：（1）建立科学的机制 监督，包括对临床和统计专业知识的支持，以及（2）制定一个安全， 符合HIPPA标准的基于云的“格鲁吉亚CF数据仓库”，将作为数据存储库 从我们的891名CF患者（701名）收集的CF相关临床和实验室数据 埃默里+亚特兰大儿童项目，奥古斯塔大学项目190人）。