Epigenetic mechanisms regulating neuron production during cortical development

皮质发育过程中调节神经元产生的表观遗传机制

• 批准号: 10259827
• 负责人: Louis-Jan Pilaz
• 金额: $ 46.37万
• 依托单位: SANFORD RESEARCH/USD
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10259827
• 关键词: Advisory Committees; Animal Model; Applications Grants; Basic Science; Biochemical; Biochemistry; Bioinformatics; Caring; Cell Proliferation; Cell physiology; Cells; Cellular biology; Centers of Research Excellence; Cessation of life; Child; Child Development; Child Health; Childhood; Clinic; Clinical; Clinical Research; Communities; Complement; Core Facility; Data; Development; Developmental Biology; Developmental Process; Diagnosis; Disease; Effectiveness; Environment; Epigenetic Process; Evaluation; Fostering; Foundations; Funding; Genetic; Genetic Diseases; Goals; Growth and Development function; Health; Healthcare Systems; Human Biology; Human Development; Image; Institution; Interdisciplinary Study; K-12 student; Leadership; Learning; Medical Students; Medicine; Mentors; Mentorship; Mind; Modeling; Molecular; Molecular Biology; Morphogenesis; Neurons; Pediatric Hospitals; Pediatric Research; Phase; Physicians; Plant Roots; Postdoctoral Fellow; Production; Regulation; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Resources; Role; Rural; Science; Scientist; Sioux Falls; South Dakota; Technical Expertise; Training; Translational Research; United States; United States National Institutes of Health; base; collaborative environment; data submission; experience; fetal programming; functional genomics; graduate student; human disease; improved; innovation; learning community; medical specialties; member; migration; multidisciplinary; northern plains; outreach; pressure; recruit; skills; success; supportive environment; training opportunity; translational study; undergraduate student

The primary goal of this application is to establish a foundation of basic scientists with translational research projects studying developmental mechanisms underlying children’s disease by establishing the Center for Pediatric Research. The origin of many pediatric diseases is from altered developmental programming related to the processes of cell proliferation, morphogenesis, migration, differentiation, and programmed death. These developmental processes are at the root of pediatric disease and are disrupted through genetic disorders, aberrant fetal programming, altered growth & development, and environmental pressures. Our multidisciplinary Center applies genetic, biochemical, cell, and molecular approaches across several model organisms to characterize alterations during development as they pertain to pediatric diseases and disorders. For phase II we will continue to build upon the success of phase I efforts to create a critical mass of independently funded investigators within the Center for Pediatric Research by refining our focus to support and mentor junior investigators whose research investigates how key regulators of cellular pliancy contribute to the developmental origin of pediatric disorders. Center success will be achieved through the following Aims: 1) create a supportive environment for the training and mentorship of scientists studying how regulation of cell pliancy contributes to pediatric diseases; 2) utilize and enhance existing resources that will enable pediatric research; 3) expand training and learning opportunities in developmental biology and pediatric disease; and 4) evaluate success of the Center. Through these Aims, the Center for Pediatric Research will develop a strong foundation in basic and translational research by fostering a collaborative environment for scientists and physicians. Strengthened by our institution’s strong commitment to children’s medicine, we propose that the Center will continue to enhance pediatric research efforts in South Dakota.

该应用程序的主要目标是为具有翻译研究的基础科学家奠定基础 通过建立儿童疾病研究中心研究儿童疾病的发展机制的项目 儿科研究。许多儿科疾病的起源是由于发育程序的改变。 细胞的增殖、形态发生、迁移、分化和程序性死亡的过程。这些 发育过程是儿科疾病的根源，并通过遗传障碍被破坏， 异常的胎儿程序，改变的生长发育，以及环境压力。我们的多学科 中心将遗传、生化、细胞和分子方法应用于几种模式生物 描述发育过程中的变化，因为它们与儿科疾病和障碍有关。第二阶段 我们将继续在第一阶段工作的成功基础上，创造一个足够多的独立资助的 儿科研究中心内的研究人员通过细化我们的重点来支持和指导孩子 研究人员，他们的研究调查了细胞柔韧性的关键调节因素是如何对 儿科疾病的发育起源。中心的成功将通过以下目标实现：1) 为研究细胞调控的科学家创造一个支持性的培训和指导环境 柔韧性有助于儿科疾病；2)利用和加强现有资源，使儿科能够 研究；3)扩大发育生物学和儿科疾病方面的培训和学习机会；4) 评估中心的成功。通过这些目标，儿科研究中心将发展一个强大的 为基础研究和翻译研究奠定基础，为科学家和 医生。由于我们机构对儿童医学的坚定承诺，我们建议 该中心将继续加强南达科他州的儿科研究工作。