1/2 CCNY-MSKCC Partnership for Cancer Research, Education and Community Outreach

1/2 CCNY-MSKCC 癌症研究、教育和社区外展合作伙伴关系

• 批准号: 10260492
• 负责人: Tim Alan Ahles
• 金额: $ 151.7万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260492
• 关键词: Address; Affect; African American; Area; Award; Biomedical Engineering; Bone neoplasms; Breast Cancer Early Detection; Cancer Research Project; Cell Line; Cellular biology; Certification; Cities; Clinical; Collaborations; Communities; Community Health Aides; Community Networks; Community Outreach; Computers; Data; Deuterium Oxide; Development; Drug Delivery Systems; Education; Education and Outreach; Elderly; Engineering; Environment; Funding; Future; Genome Stability; Goals; Grant; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Resources; Image; Immersion; Immunoglobulin Genes; Immunology; Institution; Institutional Policy; Intervention; Label; Latino; Linguistics; Low income; Malignant Neoplasms; Measures; Mechanics; Medical; Medical Computer Science; Medical Imaging; Memorial Sloan-Kettering Cancer Center; Mentorship; Minority; Modeling; Multilingualism; New York; Obesity; Pilot Projects; Policies; Population Heterogeneity; Populations at Risk; Positioning Attribute; Raman Spectrum Analysis; Recording of previous events; Research; Research Activity; Research Personnel; Resource Sharing; Resources; Risk Factors; Risk Reduction; Role; Schools; Scientist; Series; Students; Testing; Training; Translational Research; Translations; Underrepresented Minority; United States Health Resources and Services Administration; Universities; Woman; anticancer research; cancer care; cancer cell; cancer clinical trial; cancer education; cancer health disparity; cancer risk; cancer subtypes; career; clinical care; college; colorectal cancer screening; community engaged research; disparity reduction; education research; experience; health disparity; high risk; improved; innovation; interest; low socioeconomic status; medical schools; medically underserved; molecular imaging; multiphoton microscopy; outreach; pedagogy; post-doctoral training; programs; screening; socioeconomics; success; translational cancer research; translational medicine; tumor; underrepresented minority student; underserved community; working group

The CCNY-MSKCC Partnership has successfully created a mutually beneficial, cross-institutional collaboration that has emphasized research across the translational continuum, the creation of an education pipeline for attracting minority and low-income students to careers in cancer research, and the establishment of community networks and resources for conducting linguistically and culturally-responsive community engaged research among diverse, at-risk populations. Over the last five years, areas of particular strength have been developed, including: 1) rich collaborations between engineers and computer scientists at CCNY and clinicians and imaging experts at MSKCC to develop innovative solutions to improve cancer care, and 2) sustainable, translational health disparities research and activities that directly benefit underserved communities in New York, and serve as national models in terms of: a) screening / identification of cancer risk factors that disproportionately affect minorities; b) socioeconomic determinants of access to, and successful completion of, treatment; and c) policy change. Consistent with these areas of emphases, we propose two full projects that focus on: 1) Tumor ensemble models to predict tumor dormancy and reactivation and testing how these models perform across various ethnic cell lines, e.g., triple negative tumors that disproportionately affect African American women and 2) Characterizing the Role of ATM in Immunoglobulin Gene Diversification and Genome Stability. Two proposed pilot projects include: 1) Raman spectroscopy with heavy water labeling and multiphoton microscopy to allow early detection of breast cancer subtypes, including triple negative cancers and 2) Development of Mechanical Interventions to Enhance Drug Delivery to Bone Tumors. New innovative Partnership components include: 1) development of the Linguistic and Cultural Responsiveness Shared Resource Core; 2) formation of the Engineering Health Disparities working group; and 3) new educational programs including the Scholars for the Future program and the Certificate for Medical Translation and Interpretation. The Partnership specific aims are to: 1) Continue to develop outstanding cancer research programs in health disparities, biomedical engineering, computer science / medical imaging, cancer cell biology, and immunology along the Translational Research Continuum; 2) collaborate with diverse communities to conduct and facilitate trailblazing cancer disparities research, and outreach, education, risk reduction, and navigation activities to define and address cancer disparities, with the goal of improving cancer care in the large, medically underserved local and national communities; 3) continue to develop and expand educational opportunities in a robust translational cancer research environment to attract and retain students interested in cancer research (particularly minority and low income students); these opportunities will be enhanced by educational opportunities and increased mentorship and support; and 4) expand and integrate the personnel, resources, and environment needed for scientific collaboration across institutions and influence institutional policies in support of this objective.

CCNY-MSKCC合作伙伴关系成功建立了互惠互利的跨机构合作 这强调了整个翻译连续性的研究，这是建立教育管道的 吸引少数民族和低收入学生从事癌症研究的职业，并建立社区 网络和资源用于语言和文化响应的社区参与研究 在多样化的高风险人群中。在过去的五年中，已经开发了特殊力量的领域 包括：1）CCNY与临床医生的工程师与计算机科学家之间的丰富合作以及成像 MSKCC的专家开发了改善癌症护理的创新解决方案，2）可持续的转化 健康差异研究和直接受益于纽约服务不足社区的活动，并为 作为国家模型，以：a）筛查 /鉴定对影响不成比例的癌症风险因素 少数民族； b）社会经济的决定因素，即获得和成功完成治疗；和c）政策 改变。与这些重点相一致，我们提出了两个关注的完整项目：1）肿瘤 整体模型，以预测肿瘤休眠和重新激活，并测试这些模型如何跨越 各种种族细胞系，例如三重阴性肿瘤，对非裔美国妇女的影响不成比例 2）表征ATM在免疫球蛋白基因多样化和基因组稳定性中的作用。提出了两个 试点项目包括：1）带有重水标签和多光子显微镜的拉曼光谱学允许 乳腺癌亚型的早期检测，包括三重阴性癌和2）机械的发展 干预措施以增强药物递送到骨肿瘤。新的创新伙伴关系组件包括：1） 语言和文化响应能力的发展共享资源核心； 2）形成 工程健康差异工作组； 3）新的教育计划，包括 未来计划以及医学翻译和解释证书。伙伴关系具体的目的是 至：1）继续开发出杰出的健康差异癌症研究计划，生物医学 工程，计算机科学 /医学成像，癌细胞生物学和免疫学沿 翻译研究连续性； 2）与各种社区合作进行和促进开拓性 癌症差异研究，外展，教育，降低风险和导航活动以定义和 解决癌症差异，目的是改善医疗服务不足的局部和 国家社区； 3）继续在强大的翻译中发展和扩大教育机会 癌症研究环境吸引和保留对癌症研究感兴趣的学生（尤其是少数民族 和低收入学生）；这些机会将通过教育机会增强并增加 指导和支持； 4）扩大和整合所需的人员，资源和环境 跨机构的科学合作并影响机构政策以支持这一目标。