Exploring Multiple Environmental Exposures in Combination as Risk Factors for Adverse Pregnancy Outcomes

探索多种环境暴露组合作为不良妊娠结果的风险因素

• 批准号: 10266746
• 负责人: Kari Ann Weber
• 金额: $ 4.06万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10266746
• 关键词: Address; Affect; Air Pollutants; Air Pollution; Area; Birth; California; Censuses; Characteristics; Complex; Congenital Abnormality; Data; Databases; Defect; Disease; Environment; Environmental Exposure; Environmental Pollution; Environmental Risk Factor; Etiology; Exposure to; Fetal Development; Goals; Green space; Infant; Joints; Life Cycle Stages; Link; Literature; Location; Maternal Mortality; Measurement; Measures; Neighborhoods; Neonatal Mortality; Noise; Outcome; Pesticides; Pollution; Pre-Eclampsia; Pregnancy; Pregnant Women; Research; Risk Factors; Social Interaction; Socioeconomic Status; Source; Stress; Structural Congenital Anomalies; Technology; Time; United States; Vulnerable Populations; Woman; Work; adverse birth outcomes; adverse pregnancy outcome; agricultural pesticide; cohort; experience; improved; infant death; population based; prenatal; residence; social; social factors; social stress

PROJECT SUMMARY Pregnant women and their developing fetuses are particularly vulnerable, making life-course research, particularly regarding environmental exposures, highly important. However, traditional research of environmental exposures during gestation focused on one exposure at a time with limited results. Recently, the concept of the “exposome,” or the measurement of the totality of one’s exposures has emerged, emphasizing the importance of considering as many of one’s exposures as possible. The exposome consists of three domains: the internal, specific external, and general external. The internal comprises the “omics” technologies while the specific external comprises exposures such as environmental contaminants and the general external comprises social factors and stress. In this project, I endeavor to combine multiple measures of the specific external environment, specifically pesticides and air pollution, with aspects of the general external environment such as measures of socioeconomic status, along with measures of greenspace, during the prenatal period. I will investigate the association of this complex combination of exposures with the adverse pregnancy outcomes, preeclampsia and structural birth defects. Preeclampsia is a condition affecting 5% of pregnant women in the United States and is a major cause of maternal and neonatal mortality and other adverse birth outcomes. In previous work, we also observed an association between preeclampsia and selected structural birth defects. Birth defects affect roughly 3% of births in the United States and are the top cause of infant death. Etiologies of both preeclampsia and birth defects remain mostly unknown and research regarding environmental risk factors of both is limited. Thus, I will utilize the rich data available in a large birth cohort from the San Joaquin Valley in California, a region of one of the highest agricultural pesticide use areas and high air pollutant levels in the US, to investigate the association between this combination of environmental exposures with preeclampsia and the joint outcome of preeclampsia and birth defects.

项目摘要 孕妇及其发育中的胎儿尤其脆弱， 研究，特别是关于环境暴露的研究，非常重要。但传统 妊娠期环境暴露的研究集中在一次暴露一次， 结果有限。最近，“麻烦”的概念，或对整体的测量， 一个人的曝光已经出现，强调了考虑尽可能多的一个人的重要性。 尽可能的暴露。麻烦由三个领域组成：内部，特定的外部， 一般外部。内部包括“组学”技术，而具体的 外部包括暴露，例如环境污染物和一般外部 包括社会因素和压力。在这个项目中，我奋进将联合收割机的多种措施结合起来， 具体的外部环境，特别是农药和空气污染， 一般外部环境，如社会经济地位的衡量标准，沿着 绿色空间，在产前时期。我将研究这个复合体 暴露与不良妊娠结局、先兆子痫和结构性 出生缺陷先兆子痫是一种影响美国5%孕妇的疾病 并且是产妇和新生儿死亡以及其他不良出生结果的主要原因。在 在先前的工作中，我们还观察到先兆子痫与选择性结构性疾病之间的关联。 出生缺陷出生缺陷影响了美国大约3%的新生儿，是最主要的原因。 婴儿死亡。先兆子痫和出生缺陷的病因大多仍不清楚， 关于两者的环境风险因素的研究是有限的。因此，我将利用丰富的数据 在来自加州圣华金河谷的一个大型出生队列中， 最高的农业农药使用地区和高空气污染物水平在美国，调查 环境暴露与先兆子痫的这种组合与 先兆子痫和出生缺陷的联合结果。