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Study of a corticotropin releasing factor-1 receptor antagonist for the treatment of congenital adrenal hyperplasia

Study of a corticotropin releasing factor-1 receptor antagonist for the treatment of congenital adrenal hyperplasia
促肾上腺皮质激素释放因子1受体拮抗剂治疗先天性肾上腺皮质增生症的研究
批准号：
10266561
负责人：
Deborah Merke
金额：
$0.2万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10266561
关键词：
Adrenal GlandsAdrenal hormone preparationAffinityAndrogensCRF receptor type 1Clinical ResearchCongenital adrenal hyperplasiaCorticotropinCorticotropin-Releasing HormoneDoseGlucocorticoidsHormone AntagonistsHypothalamic structureInvestigationMulti-Institutional Clinical TrialPhasePituitary Glandhealthy volunteernovel therapeuticsreceptorsafety studysmall molecule

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英文摘要
Excess glucocorticoid therapy is often needed to control the overproduction of adrenal androgens in congenital adrenal hyperplasia. A phase 2 multicenter clinical trial is underway which is exploring dose finding as well as efficacy of a high-affinity and selective small-molecule antagonist of CRH type 1 receptors in the pituitary gland. The mechanism of action has been validated in a previous proof-of-concept study and has been shown to be safe in Phase 1 clinical studies in healthy volunteers. This study represents an early stage of the investigation of a novel therapy in the treatment of congenital adrenal hyperplasia.
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Study of a corticotropin releasing factor-1 receptor antagonist for the treatment of congenital adrenal hyperplasia
  • 批准号：
    10916863
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    Deborah Merke
  • 依托单位：
    CLINICAL CENTER