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Modified-release Hydrocortisone Therapy as a Treatment for CAH

Modified-release Hydrocortisone Therapy as a Treatment for CAH
改良释放氢化可的松疗法治疗 CAH
批准号：
8941563
负责人：
Deborah Merke
金额：
$0.0万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8941563
关键词：
Adrenal Cortex DiseasesAdrenal GlandsAdrenal gland hypofunctionAldosteroneAndrogensBiochemical MarkersCircadian RhythmsClinicalClinical TrialsCongenital adrenal hyperplasiaDataData AnalysesDexamethasoneDiseaseDrug Delivery SystemsDrug FormulationsDrug KineticsEnrollmentFailureGlucocorticoidsGoalsGrowthHormone replacement therapyHormonesHourHydrocortisoneInfertilityLifeMetabolic syndromeObesityOsteoporosisOutcomeParticipantPatientsPhasePilot ProjectsPrednisoneSteroid 21-MonooxygenaseTherapeuticTimeVirilismdesignimprovednovel strategiesprograms

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英文摘要
This study has completed enrollment of all 16 participants. Pharmacokinetic data has been obtained on all patients. This clinical trial has ended and data analysis is underway. Chronocort is a modified release therapy that delivers hydrocortisone in a manner that mimics the bodys normal circadian rhythm (the bodys natural, 24-hour hormone cycle). This therapeutic approach has the potential to help patients suffering from diseases due to cortisol deficiency: congenital adrenal hyperplasia and adrenal insufficiency. Each of these diseases requires life-long treatment and this novel approach to drug delivery has the potential to significantly improve patients lives.
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