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Modified-release Hydrocortisone Therapy as a Treatment for CAH

Modified-release Hydrocortisone Therapy as a Treatment for CAH
改良释放氢化可的松疗法治疗 CAH
批准号：
8941563
负责人：
Deborah Merke
金额：
$0.0万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8941563
关键词：
Adrenal Cortex DiseasesAdrenal GlandsAdrenal gland hypofunctionAldosteroneAndrogensBiochemical MarkersCircadian RhythmsClinicalClinical TrialsCongenital adrenal hyperplasiaDataData AnalysesDexamethasoneDiseaseDrug Delivery SystemsDrug FormulationsDrug KineticsEnrollmentFailureGlucocorticoidsGoalsGrowthHormone replacement therapyHormonesHourHydrocortisoneInfertilityLifeMetabolic syndromeObesityOsteoporosisOutcomeParticipantPatientsPhasePilot ProjectsPrednisoneSteroid 21-MonooxygenaseTherapeuticTimeVirilismdesignimprovednovel strategiesprograms

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中文摘要
翻译
本研究已完成所有16名受试者的入组。已获得所有患者的药代动力学数据。该临床试验已结束，数据分析正在进行中。Chronocort是一种改良释放疗法，以模仿人体正常昼夜节律（人体自然的24小时激素周期）的方式释放氢化可的松。这种治疗方法有可能帮助患有皮质醇缺乏症的患者：先天性肾上腺皮质增生和肾上腺皮质功能不全。这些疾病中的每一种都需要终身治疗，这种新的药物输送方法有可能显着改善患者的生活。
英文摘要
This study has completed enrollment of all 16 participants. Pharmacokinetic data has been obtained on all patients. This clinical trial has ended and data analysis is underway. Chronocort is a modified release therapy that delivers hydrocortisone in a manner that mimics the bodys normal circadian rhythm (the bodys natural, 24-hour hormone cycle). This therapeutic approach has the potential to help patients suffering from diseases due to cortisol deficiency: congenital adrenal hyperplasia and adrenal insufficiency. Each of these diseases requires life-long treatment and this novel approach to drug delivery has the potential to significantly improve patients lives.
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