Core E: Laboratory and biobehavioral marker core

核心E：摘要/摘要 与该中心的主题一致，核心E的使命是促进广泛的生物和 旨在优化精神、行为和医学结果的行为干预研究 在感染艾滋病毒的人中。核心将对所有试点项目进行分析，以及设计和 实施新的分析方法。这一核心将执行实验室和成像评估，以定义 与艾滋病毒/艾滋病相关的疾病和共病，以及与各种 行为和药物干预。核心将受益于佩雷尔曼的主要优势 宾夕法尼亚大学医学院(PSOM)、CHOP、中心、科室和学校。我们将确定具体的 以及可能与精神疾病和艾滋病毒/艾滋病共病有关的独特生物标记物。这些 将收集所有将在飞行员和其他核心研究中研究的对象的数据。核心将执行以下测试 体液和细胞，包括免疫、炎症、压力和健康的标志物。核心还将携带 进行神经成像和神经认知测量。核心意愿与艾滋病毒治疗相关的评估， 精神健康，以及并存疾病。《核心》由道格拉斯博士和古尔博士两位资深调查人员执导。这个 CORE将支持该中心的科学议程和发展计划。此核心资源将密切关注 与宾夕法尼亚大学的现有资源互动，这些资源对PMHARC的使命至关重要。核心总监， 道格拉斯和联席董事古尔在宾夕法尼亚大学担任领导职务。核心将被独特地定位为携带 监督管理标准化精选影像、生化的质量控制和质量保证 标记物、神经心理行为测试和实验室测试。核心将与所有 其他PMHARC核心，以及与临床评估核心关系最密切的核心，以努力收集综合 一组患有各种精神疾病的HIV+患者的生物医学和行为数据 为了更好地了解疾病轨迹、发病率和临床结果。

CORE E: ABSTRACT/SUMMARY Consistent with the Center's theme, the mission of Core E is to facilitate a broad range of biological and behavioral intervention studies that are designed to optimize psychiatric, behavioral, and medical outcomes among HIV infected individuals. The Core will perform assays for all Pilot Projects, as well as design and implement novel assays. This Core will perform laboratory and imaging assessments that define the mental illnesses and co-morbidities related to HIV/AIDS and unique modeling and measurements related to various behavioral and pharmacologic interventions. The Core will benefit from the major strengths of the Perelman School of Medicine (PSOM), CHOP, Centers, Departments, and Schools at UPenn. We will identify specific and potentially unique biomarkers which are related to mental illness and to comorbidities of HIV/AIDS. These data will be collected for all subjects to be studied in pilots and other Cores. The Core will perform assays of body fluids and cells including markers of immunity, inflammation, stress, and health. The Core will also carry out neuroimaging and neurocognitive measures. The Core will assessments related to therapeutics for HIV, mental health, and co-morbidities. The Core is directed by two senior investigators, Drs. Douglas and Gur. The Core will support the Center's scientific agenda and developmental program. This Core resource will closely interact with existing resources at UPenn, which are central to the mission of the PMHARC. The Core Director, Douglas, and Co-Director, Gur, are in leadership roles at UPenn. The Core will be uniquely positioned to carry out and monitor the quality control and quality assurance of standardized selected imaging, biochemical markers, neuropsychological behavioral testing, and laboratory testing. The Core will work closely with all the other PMHARC Cores, and most closely with the Clinical Assessment Core, in an effort to gather integrated 'state-of-the-art' biomedical and behavioral data on a cohort of HIV+ persons with a variety of mental illnesses in an effort to better understand disease trajectories, morbidities and clinical outcomes.