Core A

核心A将服务于新的neuroAIDS疗法中的所有项目和核心：综合临床前/临床 IPCP将负责监督科学、行政、监管和运营方面的工作 该计划的活动。行政核心的总体目标是使IPCP能够履行其 科学使命，如本提案开头的导言和概述中所定义的，作为一种特定的 三个项目的具体目标。首席研究员Steven D.道格拉斯，将指导这一点 核心，并将提供领导，方向和组织的整体计划项目的努力，并协助 每个项目负责人和核心负责人成功执行其计划的实验，或 支助服务.管理核心的目标是：（1）协调和监督本IPCP; (2)通过协调定期审查研究结果和整合，监督IPCP的发展计划 将这些信息纳入决策过程，这是药物开发使命的组成部分。 （3）促进研究项目之间的高度合作和协同互动， 研究者和核心领导人;（4）促进本IPCP参与NIH IPCP计划活动;（5） 确保各个项目有效和适当地利用核心服务;（6）提供调查员和 核心主任及时获得关于核心和项目支出及资源的准确信息; (7)确保项目的开发计划符合所有适用的法规 指导方针和NIH的政策和程序;（8）组织和实施定期的内部和外部 监督IPCP的活动;以及（9）支持该计划履行其与以下有关的义务： 信息传播、科学出版和数据共享。这将包括管理 与CHOP技术转让部合作解决知识产权问题。的 行政核心将由所有参与项目和科学核心平等使用。

Core A will serve all projects and cores in the Novel neuroAIDS Therapies: Integrated Preclinical/Clinical IPCP and will be responsible for oversight ofthe scientific, administrative, regulatory and operational aspects of the program's activities. The overall goal of the Administrative Core is to enable the IPCP to fulfill its scientific mission, as defined in the introduction and overview at the beginning of this proposal, as a specified in the Specific Aims of the three projects. The Principal Investigator, Dr. Steven D. Douglas, will direct this core and will provide leadership, direction, and organization to the overall program project effort and assist each of the Project Leaders and Core Leaders in the successful execution of their planned experiments or support services. The objectives ofthe Administrative Core are to: (1) Coordinate and supervise this IPCP; (2) Oversee the development plan ofthe IPCP by coordinating regular review of study results and integration of this information into the decision-making process that is integral to the drug development mission of the research program; (3) Promote a high degree of collaboration and synergistic interaction among the investigators and core leaders; (4) Facilitate participation of this IPCP within NIH IPCP Program activities; (5) Insure efficient and appropriate use of core services by the individual projects; (6) Provide investigators and core directors with timely and accurate information regarding core and project expenditures and resources; (7) Insure that the program's development plan is conducted in compliance with all applicable regulatory guidelines and NIH policies and procedures; (8) Organize and implement regular internal and external oversight of the IPCP's activities; and, (9) Support the program in fulfilling its obligations related to information dissemination, scientific publication and data sharing. This will include management of intellectual property issues in collaboration with the CHOP Department of Technology Transfer. The Administrative Core will be utilized equally by all participating projects and scientific cores.