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Integrating experimental and field studies to understand PFAS bioaccumulation and impact in aquatic food webs

结合实验和现场研究，了解 PFAS 的生物累积及其对水生食物网的影响

基本信息

批准号：
10559573
负责人：
Antonio J. Planchart
金额：
$ 19.66万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-03 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10559573
关键词：
Address Affect Age Alligators Apical Biology Chemical Structure Chemicals Clinical Cohort Studies Complement Consumption Controlled Study Diet Ecosystem Environment Environmental Engineering technology Environmental Science Evaluation Exposure to Fishes Food Food Webs Fresh Water Fright Future Generations Goals Hazard Assessment Health Human Individual Investigation Kinetics Laboratories Laboratory Study Life Link Measures Modeling Movement Nature Organism Outcome Persons Phase Poly-fluoroalkyl substances Production Reporting Research Research Project Grants Resources Risk Management Safety Sampling Source Structure Superfund Testing Tissues Toxic effect Uncertainty Water Work Zebrafish aquatic organism aqueous bioaccumulation chemical release dietary drinking water experimental study exposed human population exposure pathway exposure route field study immune function laboratory experiment manufacturing facility nutrition predictive modeling uptake

项目摘要

ABSTRACT (Environmental Science and Engineering) Research Project 3 Per- and polyfluoroalkyl substances (PFAS) are chemicals that are of emerging concern because they are widely released into the environment where they tend to be persistent and bioaccumulative. Some PFAS are associated with adverse health outcomes in people, and production of a limited number of them (e.g., PFOA and PFOS) has been phased out due to these concerns. However, there are approximately 5,000 PFAS, and there is considerable uncertainty regarding the human health and environmental safety of these compounds because most PFAS have never been tested. Because these compounds are routinely released into waterways that serve as sources of drinking water and nutrition via consumption of fish and aquatic wildlife, there is an immediate need to better understand their environmental fate and effects. As concerns about PFAS in the environment are beginning to grow, there are increasing reports of the presence of these compounds in water and in aquatic organisms, but our understanding of their bioaccumulation potential and toxicity to aquatic life is limited. This project specifically addresses concerns about the bioaccumulation and toxicity of PFAS in aquatic food webs. One major goal of this project is to compare the accumulation of PFAS (12 different compounds) in a food web context by comparing aqueous uptake in primary producers (periphyton), primary consumers (mayflies), and secondary consumers (zebrafish) in the laboratory. A second major goal is to understand the potential for different compounds to move trophically in food webs by measuring the movement of different compounds from periphyton to mayflies to fish. Only by doing controlled studies in the laboratory can we systematically understand the bioaccumulation dynamics of these different compounds based on their different chemical structures. The next major goal of this work is to compare the toxicity of different PFAS to zebrafish. While zebrafish is a recognized model for human health studies, this project utilizes the deep understanding of this species' biology to explore the consequences of PFAS exposure to fish. The project will compare the toxicity of 12 different compounds in zebrafish using traditional toxicity approaches (exposures from water) but will be unique in that it will also assess the potential for dietary PFAS exposures to contribute to toxicity because in nature, exposures are likely to both PFAS in water and in the diet. Finally, these laboratory studies will be complemented by field investigations of PFAS in local waterways and in the tissues of aquatic fish and wildlife. This work is prompted by local contamination of a major watershed by a PFAS manufacturing plant and associated concerns about real-world exposures. Specifically, the project will measure PFAS in fish and wildlife (alligators) that are potential dietary exposure routes of these contaminants to people. Together, the project will provide much needed information about the bioaccumulation, toxicity, and exposure profiles of PFAS in the aquatic environment.

摘要