Integrating experimental and field studies to understand PFAS bioaccumulation and impact in aquatic food webs

结合实验和现场研究,了解 PFAS 的生物累积及其对水生食物网的影响

基本信息

项目摘要

ABSTRACT (Environmental Science and Engineering) Research Project 3 Per- and polyfluoroalkyl substances (PFAS) are chemicals that are of emerging concern because they are widely released into the environment where they tend to be persistent and bioaccumulative. Some PFAS are associated with adverse health outcomes in people, and production of a limited number of them (e.g., PFOA and PFOS) has been phased out due to these concerns. However, there are approximately 5,000 PFAS, and there is considerable uncertainty regarding the human health and environmental safety of these compounds because most PFAS have never been tested. Because these compounds are routinely released into waterways that serve as sources of drinking water and nutrition via consumption of fish and aquatic wildlife, there is an immediate need to better understand their environmental fate and effects. As concerns about PFAS in the environment are beginning to grow, there are increasing reports of the presence of these compounds in water and in aquatic organisms, but our understanding of their bioaccumulation potential and toxicity to aquatic life is limited. This project specifically addresses concerns about the bioaccumulation and toxicity of PFAS in aquatic food webs. One major goal of this project is to compare the accumulation of PFAS (12 different compounds) in a food web context by comparing aqueous uptake in primary producers (periphyton), primary consumers (mayflies), and secondary consumers (zebrafish) in the laboratory. A second major goal is to understand the potential for different compounds to move trophically in food webs by measuring the movement of different compounds from periphyton to mayflies to fish. Only by doing controlled studies in the laboratory can we systematically understand the bioaccumulation dynamics of these different compounds based on their different chemical structures. The next major goal of this work is to compare the toxicity of different PFAS to zebrafish. While zebrafish is a recognized model for human health studies, this project utilizes the deep understanding of this species' biology to explore the consequences of PFAS exposure to fish. The project will compare the toxicity of 12 different compounds in zebrafish using traditional toxicity approaches (exposures from water) but will be unique in that it will also assess the potential for dietary PFAS exposures to contribute to toxicity because in nature, exposures are likely to both PFAS in water and in the diet. Finally, these laboratory studies will be complemented by field investigations of PFAS in local waterways and in the tissues of aquatic fish and wildlife. This work is prompted by local contamination of a major watershed by a PFAS manufacturing plant and associated concerns about real-world exposures. Specifically, the project will measure PFAS in fish and wildlife (alligators) that are potential dietary exposure routes of these contaminants to people. Together, the project will provide much needed information about the bioaccumulation, toxicity, and exposure profiles of PFAS in the aquatic environment.
摘要

项目成果

期刊论文数量(0)
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Antonio J. Planchart其他文献

Antonio J. Planchart的其他文献

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{{ truncateString('Antonio J. Planchart', 18)}}的其他基金

Center for Environmental and Health Effects of PFAS
PFAS 环境与健康影响中心
  • 批准号:
    10115848
  • 财政年份:
    2020
  • 资助金额:
    $ 19.66万
  • 项目类别:
Integrating experimental and field studies to understand PFAS bioaccumulation and impact in aquatic food webs
结合实验和现场研究,了解 PFAS 的生物累积及其对水生食物网的影响
  • 批准号:
    10337309
  • 财政年份:
    2020
  • 资助金额:
    $ 19.66万
  • 项目类别:
Center for Environmental and Health Effects of PFAS
PFAS 环境与健康影响中心
  • 批准号:
    10558143
  • 财政年份:
    2020
  • 资助金额:
    $ 19.66万
  • 项目类别:
ENVIRONMENTAL TOXICANT PERTURBATION OF ZEBRAFISH GENE EXPRESSION & DEVELOPMENT
斑马鱼基因表达的环境毒性扰动
  • 批准号:
    7960062
  • 财政年份:
    2009
  • 资助金额:
    $ 19.66万
  • 项目类别:
CHARACTERIZATION OF MOTIFS REGULATING EMBRYONIC & SPERMATOGENIC GENE EXPRESSION
调控胚胎的基序的特征
  • 批准号:
    7720063
  • 财政年份:
    2008
  • 资助金额:
    $ 19.66万
  • 项目类别:

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激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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