Core of Advanced Platform Technologies Used for Remediation and Exploration

用于修复和勘探的先进平台技术核心

• 批准号: 10559558
• 负责人: Erin Marie Baker
• 金额: $ 26.61万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-03 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559558
• 关键词: Address; Affect; Algorithms; Animals; Biological; Biological Models; Blood; Carbon; Chemicals; Communities; Core Facility; Data; Data Collection; Data Set; Databases; Decision Making; Development; Doctor of Philosophy; Education; Electron Microscope; Electron Microscopy; Electron energy loss spectroscopy; Ensure; Environment; Environmental Pollutants; Evaluation; Genomics; Hazardous Chemicals; Health; Human; Human Resources; Individual; Ions; Knowledge; Laboratories; Length; Mass Spectrum Analysis; Measurement; Methods; Modernization; Molecular; Monitor; PSSO3; Penetration; Phase; Phenotype; Poly-fluoroalkyl substances; Population; Procedures; Protocols documentation; Qualifying; Reaction; Reagent; Research; Research Personnel; Resource Sharing; Role; Sampling; Scanning; Sex Differences; Signal Recognition Particle; Solid; Spectrum Analysis; Stable Isotope Labeling; Superfund; Techniques; Technology; Tissues; Urine; Variant; Water; Work; X ray spectroscopy; Zebrafish; combinatorial; community engagement; dashboard; detection limit; genome sciences; high resolution imaging; improved; innovation; instrumentation; interest; ion mobility; lipidomics; metabolomics; nanometer; novel; particle; public database; remediation; species difference; technology platform; tool; transcriptome sequencing; transcriptomics; translational engagement; transmission process

ABSTRACT CAPTURE Responding to newly discovered environmental contaminants requires novel analytical approaches. The Core of Advanced Platform Technologies Used for Remediation and Exploration (CAPTURE) will provide analytical capabilities to the four projects in the NC State Superfund Research Center to enable rapid, comprehensive assessment of PFAS presence. CAPTURE is comprised of the Genomic Sciences Laboratory (GSL), the Analytical Instrumentation Facility (AIF), and the Molecular Education, Technology, and Research Innovation Center (METRIC) at NC State, which have over $25M in modern instrumentation and are operated by more than 20 PhD-level, highly qualified personnel. These capabilities provide CAPTURE with the ability to explore the diversity of scientific questions with a broad range of measurements including RNA-seq, materials characterization, and mass spectrometry analyses for the known and unknown per- and polyfluoroalkyl substances (PFAS). New methods and reagents will result from this work which will enable and inform the entire scientific community about PFAS in the environment. Additionally, CAPTURE will enhance interactions among Center projects and other cores, increasing their impact by ensuring synchronization of exposure measurements and increasing their value in decision-making, translation, and community engagement.

摘要 捕获 应对新发现的环境污染物需要新的分析方法。 用于补救和勘探(捕获)的高级平台技术的核心将 为NC国家超级基金研究中心的四个项目提供分析能力，以实现 快速、全面地评估全氟辛烷磺酸的存在。捕获由基因组组成 科学实验室(GSL)、分析仪器设备(AIF)和分子教育， 北卡罗来纳州的技术和研究创新中心(公制)，拥有超过2500万美元的现代化 该仪器由20多名博士级别、高素质的人员操作。这些 功能为捕获提供了探索多样性的科学问题的能力 测量范围包括rna-seq、材料表征和质谱学。 已知和未知的全氟烷基和多氟烷基物质(PFAS)的分析。新方法和新方法 这项工作将产生试剂，这将使整个科学界能够并了解 环境中的全氟化铝。此外，Capture还将加强中心项目和 其他核心，通过确保曝光测量和 提高它们在决策、翻译和社区参与方面的价值。