Core of Advanced Platform Technologies Used for Remediation and Exploration

用于修复和勘探的先进平台技术核心

• 批准号: 10559558
• 负责人: Erin Marie Baker
• 金额: $ 26.61万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-03 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559558
• 关键词: Address; Affect; Algorithms; Animals; Biological; Biological Models; Blood; Carbon; Chemicals; Communities; Core Facility; Data; Data Collection; Data Set; Databases; Decision Making; Development; Doctor of Philosophy; Education; Electron Microscope; Electron Microscopy; Electron energy loss spectroscopy; Ensure; Environment; Environmental Pollutants; Evaluation; Genomics; Hazardous Chemicals; Health; Human; Human Resources; Individual; Ions; Knowledge; Laboratories; Length; Mass Spectrum Analysis; Measurement; Methods; Modernization; Molecular; Monitor; PSSO3; Penetration; Phase; Phenotype; Poly-fluoroalkyl substances; Population; Procedures; Protocols documentation; Qualifying; Reaction; Reagent; Research; Research Personnel; Resource Sharing; Role; Sampling; Scanning; Sex Differences; Signal Recognition Particle; Solid; Spectrum Analysis; Stable Isotope Labeling; Superfund; Techniques; Technology; Tissues; Urine; Variant; Water; Work; X ray spectroscopy; Zebrafish; combinatorial; community engagement; dashboard; detection limit; genome sciences; high resolution imaging; improved; innovation; instrumentation; interest; ion mobility; lipidomics; metabolomics; nanometer; novel; particle; public database; remediation; species difference; technology platform; tool; transcriptome sequencing; transcriptomics; translational engagement; transmission process

ABSTRACT CAPTURE Responding to newly discovered environmental contaminants requires novel analytical approaches. The Core of Advanced Platform Technologies Used for Remediation and Exploration (CAPTURE) will provide analytical capabilities to the four projects in the NC State Superfund Research Center to enable rapid, comprehensive assessment of PFAS presence. CAPTURE is comprised of the Genomic Sciences Laboratory (GSL), the Analytical Instrumentation Facility (AIF), and the Molecular Education, Technology, and Research Innovation Center (METRIC) at NC State, which have over $25M in modern instrumentation and are operated by more than 20 PhD-level, highly qualified personnel. These capabilities provide CAPTURE with the ability to explore the diversity of scientific questions with a broad range of measurements including RNA-seq, materials characterization, and mass spectrometry analyses for the known and unknown per- and polyfluoroalkyl substances (PFAS). New methods and reagents will result from this work which will enable and inform the entire scientific community about PFAS in the environment. Additionally, CAPTURE will enhance interactions among Center projects and other cores, increasing their impact by ensuring synchronization of exposure measurements and increasing their value in decision-making, translation, and community engagement.

摘要 捕获 应对新发现的环境污染物需要新的分析方法。 用于修复和勘探的先进平台技术的核心（CAPTURE）将 为北卡罗来纳州超级基金研究中心的四个项目提供分析能力， 快速、全面地评估PFAS的存在。CAPTURE由基因组 科学实验室（GSL），分析仪器设施（AIF）和分子教育， 技术和研究创新中心（METRIC）在北卡罗来纳州，其中有超过2500万美元的现代 仪器和操作由20多个博士水平，高素质的人员。这些 能力为CAPTURE提供了探索科学问题多样性的能力， 测量范围包括RNA-seq、材料表征和质谱分析 分析已知和未知的全氟烷基和多氟烷基物质（PFAS）。新方法和 这项工作将产生试剂，这将使整个科学界了解 环境中的PFAS。此外，CAPTURE将增强中心项目之间的互动， 其他核心，通过确保曝光测量的同步来增加其影响， 提高他们在决策、翻译和社区参与方面的价值。