Improved Diagnostic MRI around Metallic Implants
改进金属植入物周围的 MRI 诊断
基本信息
- 批准号:10558660
- 负责人:
- 金额:$ 59.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAnatomyAreaArtificial IntelligenceCalibrationChromiumCobaltCompensationComplicationComputer softwareDecision MakingDegenerative polyarthritisDevicesDiagnosisDiagnosticEvaluationExcisionFailureFatty acid glycerol estersFractureGoalsHip region structureImageImaging TechniquesImplantMagnetic Resonance ImagingMetalsModelingMorphologic artifactsNerveNoiseOperative Surgical ProceduresOrthopedicsPatient CarePatientsPenetrationPerformancePhysiologic pulsePredispositionPropertyProtocols documentationReaderReplacement ArthroplastyResolutionShapesSignal TransductionSliceSpinalStainless SteelStandardizationStructureSurfaceSurgeonSynovitisSystemTechniquesTechnologyTimeTissue imagingTissuesTitaniumTotal Hip ReplacementTraumaVariantVertebral columnWaterX-Ray Computed Tomographybody systembonecohortdenoisingdesignhip replacement arthroplastyimaging approachimaging modalityimprovedinnovationintervertebral disk degenerationknee replacement arthroplastymagnetic fieldmetallicitymillimeternew technologynon-invasive imagingnovelpreventradio frequencyradiologistreconstructionresponsesample fixationsoft tissuespectrographstemtooltransmission process
项目摘要
PROJECT SUMMARY
This project will develop new technology for high-resolution soft-tissue MRI immediately adjacent to orthopaedic
metallic implants, an area that is “invisible” to current imaging techniques. We will leverage a novel high-
performance 0.55 Tesla MRI platform and will develop new software and tools that are optimized for this platform
and application. Finally, we evaluate the new metal MRI technology in two patient cohorts where it can
immediately impact patient management: hip replacement and spinal fixation. Rationale: Orthopaedic metal
implants are used extensively to treat late-stage osteoarthritis (total joint replacements), degenerative disc
disease (spinal fixations), and fracture stabilization following trauma or bone resection. These implants fail in
10%-40% of cases, and accurate non-invasive imaging with soft-tissue contrast is essential for the evaluation of
the underlying cause of hardware failure, and in surgical decision making and planning. At present, there is a
major unmet need for high quality soft tissue imaging immediately adjacent to the metal surface to assess, for
example, adverse local tissue response or nerve root impingement. State-of-the-art multi-spectral imaging (MSI)
led to major improvements ~10 years ago, and the technology has plateaued. Innovation: We leverage a novel
0.55T MRI system that will soon be commercially available, which alone promises reduced image artifacts,
because it provides much stronger imaging gradients relative to the susceptibility-induced gradients and field
shifts, higher-bandwidth RF pulses, uniform RF transmission, and new opportunities for improved encoding and
reconstruction. We also propose reimagined MSI pulse sequences to offer further improvements in signal-to-
noise ratio, encoding time, and artifact. Approach: Our specific aims are: 1) to adapt standard metal MSI
approaches for the 0.55T MRI platform to primarily assess the improvement of the 0.55T system alone due to
reduced off-resonance; 2) to redesign improved metal MSI approaches that leverage the gradient-to-B0 and RF
performance of the 0.55T MRI platform to compensate for lost SNR efficiency, while improving spatial resolution
and artifact suppression and offering fat/water separation; and 3) to compare 0.55T MRI and 3T MRI protocols
in patients with hip and spine implants, both to assess the improvement from the system alone and from
redesigned MSI sequences. Broader Impact: This project aims to demonstrate improved capability to image
closer to implant surfaces than what is possible at conventional 1.5T and 3T field strengths, and the impact in
the context of post-surgical evaluation of hip-replacements and spinal fixations. This will broadly benefit the use
of MRI in patients with metal, including orthopedic and non-orthopedic implants.
项目总结
该项目将开发与骨科相邻的高分辨率软组织磁共振成像的新技术
金属植入物,这是目前成像技术“看不见”的领域。我们将利用一种新的高度-
性能0.55特斯拉MRI平台,并将开发针对该平台进行优化的新软件和工具
和应用程序。最后,我们在两个患者队列中对新的金属磁共振技术进行了评估,在可能的情况下
立即影响患者处理:髋关节置换和脊柱固定。基本原理:矫形金属
植入物被广泛用于治疗晚期骨关节炎(全关节置换术)、退行性腰椎间盘
疾病(脊柱固定),以及创伤或骨切除后的骨折稳定。这些植入物在
10%-40%的病例,而准确的无创性软组织对比成像对于评估
硬件故障的根本原因,以及手术决策和规划。目前,有一种
对紧邻金属表面的高质量软组织成像的主要未满足需求,以进行评估
例如,局部组织不良反应或神经根撞击。最新的多光谱成像(MSI)
在大约10年前带来了重大改进,而这项技术已经停滞不前。创新:我们利用一种新的
即将上市的0.55T核磁共振系统,它本身就承诺减少图像伪影,
因为它提供了比磁化率引起的梯度和场强得多的成像梯度
频移、更高带宽的RF脉冲、统一的RF传输,以及改进编码和
重建。我们还提出了重新设想的MSI脉冲序列,以提供进一步的改进的信号比
噪声比、编码时间和伪影。方法:我们的具体目标是:1)采用标准金属MSI
0.55T磁共振成像平台单独评估0.55T系统改进的方法
减少非共振;2)重新设计改进的金属MSI方法,利用梯度到B0和RF
0.55T MRI平台的性能,以补偿SNR效率的损失,同时提高空间分辨率
和伪影抑制,并提供脂肪/水分离;以及3)比较0.55T MRI和3T MRI
在髋关节和脊柱植入物的患者中,评估单独使用该系统和从
重新设计了MSI序列。更广泛的影响:该项目旨在展示改进的图像处理能力
比传统的1.5T和3T场强下更接近种植体表面,以及
髋关节置换术和脊柱固定术后评估的背景。这将广泛地受益于使用
磁共振成像在金属患者中的应用,包括骨科和非骨科植入物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brian Andrew Hargreaves其他文献
Brian Andrew Hargreaves的其他文献
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{{ truncateString('Brian Andrew Hargreaves', 18)}}的其他基金
Improved Diagnostic MRI around Metallic Implants
改进金属植入物周围的 MRI 诊断
- 批准号:
10367211 - 财政年份:2022
- 资助金额:
$ 59.68万 - 项目类别:
Rapid Low-Cost Quantitative 3D MRI and Gait Assessment of the Knee
快速、低成本定量 3D MRI 和膝关节步态评估
- 批准号:
10032904 - 财政年份:2020
- 资助金额:
$ 59.68万 - 项目类别:
Rapid Low-Cost Quantitative 3D MRI and Gait Assessment of the Knee
快速、低成本定量 3D MRI 和膝关节步态评估
- 批准号:
10441342 - 财政年份:2020
- 资助金额:
$ 59.68万 - 项目类别:
Rapid Low-Cost Quantitative 3D MRI and Gait Assessment of the Knee
快速、低成本定量 3D MRI 和膝关节步态评估
- 批准号:
10671520 - 财政年份:2020
- 资助金额:
$ 59.68万 - 项目类别:
Comprehensive MRI near Total Joint Replacements
全关节置换附近的综合 MRI
- 批准号:
9101806 - 财政年份:2014
- 资助金额:
$ 59.68万 - 项目类别:
Comprehensive MRI near Total Joint Replacements
全关节置换附近的综合 MRI
- 批准号:
8755614 - 财政年份:2014
- 资助金额:
$ 59.68万 - 项目类别:
Quantitative 3D Diffusion and Relaxometry MRI of the Knee
膝关节定量 3D 扩散和松弛测量 MRI
- 批准号:
8577966 - 财政年份:2013
- 资助金额:
$ 59.68万 - 项目类别:
Quantitative 3D Diffusion and Relaxometry MRI of the Knee
膝关节定量 3D 扩散和松弛测量 MRI
- 批准号:
8926355 - 财政年份:2013
- 资助金额:
$ 59.68万 - 项目类别:
Quantitative 3D Diffusion and Relaxometry MRI of the Knee
膝关节定量 3D 扩散和松弛测量 MRI
- 批准号:
9125727 - 财政年份:2013
- 资助金额:
$ 59.68万 - 项目类别:
Quantitative 3D Diffusion and Relaxometry MRI of the Knee
膝关节定量 3D 扩散和松弛测量 MRI
- 批准号:
8731178 - 财政年份:2013
- 资助金额:
$ 59.68万 - 项目类别:
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