Improved Diagnostic MRI around Metallic Implants

改进金属植入物周围的 MRI 诊断

• 批准号: 10558660
• 负责人: Brian Andrew Hargreaves
• 金额: $ 59.68万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10558660
• 关键词: Acceleration; Anatomy; Area; Artificial Intelligence; Calibration; Chromium; Cobalt; Compensation; Complication; Computer software; Decision Making; Degenerative polyarthritis; Devices; Diagnosis; Diagnostic; Evaluation; Excision; Failure; Fatty acid glycerol esters; Fracture; Goals; Hip region structure; Image; Imaging Techniques; Implant; Magnetic Resonance Imaging; Metals; Modeling; Morphologic artifacts; Nerve; Noise; Operative Surgical Procedures; Orthopedics; Patient Care; Patients; Penetration; Performance; Physiologic pulse; Predisposition; Property; Protocols documentation; Reader; Replacement Arthroplasty; Resolution; Shapes; Signal Transduction; Slice; Spinal; Stainless Steel; Standardization; Structure; Surface; Surgeon; Synovitis; System; Techniques; Technology; Time; Tissue imaging; Tissues; Titanium; Total Hip Replacement; Trauma; Variant; Vertebral column; Water; X-Ray Computed Tomography; body system; bone; cohort; denoising; design; hip replacement arthroplasty; imaging approach; imaging modality; improved; innovation; intervertebral disk degeneration; knee replacement arthroplasty; magnetic field; metallicity; millimeter; new technology; non-invasive imaging; novel; prevent; radio frequency; radiologist; reconstruction; response; sample fixation; soft tissue; spectrograph; stem; tool; transmission process

PROJECT SUMMARY This project will develop new technology for high-resolution soft-tissue MRI immediately adjacent to orthopaedic metallic implants, an area that is “invisible” to current imaging techniques. We will leverage a novel high- performance 0.55 Tesla MRI platform and will develop new software and tools that are optimized for this platform and application. Finally, we evaluate the new metal MRI technology in two patient cohorts where it can immediately impact patient management: hip replacement and spinal fixation. Rationale: Orthopaedic metal implants are used extensively to treat late-stage osteoarthritis (total joint replacements), degenerative disc disease (spinal fixations), and fracture stabilization following trauma or bone resection. These implants fail in 10%-40% of cases, and accurate non-invasive imaging with soft-tissue contrast is essential for the evaluation of the underlying cause of hardware failure, and in surgical decision making and planning. At present, there is a major unmet need for high quality soft tissue imaging immediately adjacent to the metal surface to assess, for example, adverse local tissue response or nerve root impingement. State-of-the-art multi-spectral imaging (MSI) led to major improvements ~10 years ago, and the technology has plateaued. Innovation: We leverage a novel 0.55T MRI system that will soon be commercially available, which alone promises reduced image artifacts, because it provides much stronger imaging gradients relative to the susceptibility-induced gradients and field shifts, higher-bandwidth RF pulses, uniform RF transmission, and new opportunities for improved encoding and reconstruction. We also propose reimagined MSI pulse sequences to offer further improvements in signal-to- noise ratio, encoding time, and artifact. Approach: Our specific aims are: 1) to adapt standard metal MSI approaches for the 0.55T MRI platform to primarily assess the improvement of the 0.55T system alone due to reduced off-resonance; 2) to redesign improved metal MSI approaches that leverage the gradient-to-B0 and RF performance of the 0.55T MRI platform to compensate for lost SNR efficiency, while improving spatial resolution and artifact suppression and offering fat/water separation; and 3) to compare 0.55T MRI and 3T MRI protocols in patients with hip and spine implants, both to assess the improvement from the system alone and from redesigned MSI sequences. Broader Impact: This project aims to demonstrate improved capability to image closer to implant surfaces than what is possible at conventional 1.5T and 3T field strengths, and the impact in the context of post-surgical evaluation of hip-replacements and spinal fixations. This will broadly benefit the use of MRI in patients with metal, including orthopedic and non-orthopedic implants.

项目总结 该项目将开发与骨科相邻的高分辨率软组织磁共振成像的新技术 金属植入物，这是目前成像技术“看不见”的领域。我们将利用一种新的高度- 性能0.55特斯拉MRI平台，并将开发针对该平台进行优化的新软件和工具 和应用程序。最后，我们在两个患者队列中对新的金属磁共振技术进行了评估，在可能的情况下 立即影响患者处理：髋关节置换和脊柱固定。基本原理：矫形金属 植入物被广泛用于治疗晚期骨关节炎(全关节置换术)、退行性腰椎间盘 疾病(脊柱固定)，以及创伤或骨切除后的骨折稳定。这些植入物在 10%-40%的病例，而准确的无创性软组织对比成像对于评估 硬件故障的根本原因，以及手术决策和规划。目前，有一种 对紧邻金属表面的高质量软组织成像的主要未满足需求，以进行评估 例如，局部组织不良反应或神经根撞击。最新的多光谱成像(MSI) 在大约10年前带来了重大改进，而这项技术已经停滞不前。创新：我们利用一种新的 即将上市的0.55T核磁共振系统，它本身就承诺减少图像伪影， 因为它提供了比磁化率引起的梯度和场强得多的成像梯度 频移、更高带宽的RF脉冲、统一的RF传输，以及改进编码和 重建。我们还提出了重新设想的MSI脉冲序列，以提供进一步的改进的信号比 噪声比、编码时间和伪影。方法：我们的具体目标是：1)采用标准金属MSI 0.55T磁共振成像平台单独评估0.55T系统改进的方法 减少非共振；2)重新设计改进的金属MSI方法，利用梯度到B0和RF 0.55T MRI平台的性能，以补偿SNR效率的损失，同时提高空间分辨率 和伪影抑制，并提供脂肪/水分离；以及3)比较0.55T MRI和3T MRI 在髋关节和脊柱植入物的患者中，评估单独使用该系统和从 重新设计了MSI序列。更广泛的影响：该项目旨在展示改进的图像处理能力 比传统的1.5T和3T场强下更接近种植体表面，以及 髋关节置换术和脊柱固定术后评估的背景。这将广泛地受益于使用 磁共振成像在金属患者中的应用，包括骨科和非骨科植入物。