Novel Apolipoprotein A-I Mimetic Peptides: a Research Tool and a Therapeutic Agent to Study and Treat Atherosclerosis

新型载脂蛋白 A-I 模拟肽：研究和治疗动脉粥样硬化的研究工具和治疗剂

• 批准号: nhmrc : 1003106
• 负责人: Dr Alan Remaley
• 金额: $ 17.76万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-apolipoprotein-a-treat-atherosclerosis/108896
• 关键词: Novel; Apolipoprotein; Mimetic; Peptides; Research

Drugs affecting lipid metabolism have revolutionized the treatment of heart diseases. There is, however, an urgent need for further reduction of high remaining risk. A most promising direction is increasing levels of _good cholesterol�. A new type of such therapy are simple compounds mimicking structure of good cholesterol. We have synthesized new such compounds that are even more active than good cholesterol. Now we will test these compounds in animals and in clinical trial.

影响脂质代谢的药物已经彻底改变了心脏病的治疗。然而，迫切需要进一步降低高剩余风险。一个最有希望的方向是增加有益胆固醇的水平。一种新型的这种疗法是模仿好胆固醇结构的简单化合物。我们已经合成了新的这样的化合物，甚至比好的胆固醇更有活性。现在我们将在动物和临床试验中测试这些化合物。