权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Bioactive adhesive material for early vaginal wall detachment in pelvic organ prolapse

生物活性粘合材料治疗盆腔器官脱垂早期阴道壁脱离

基本信息

批准号：
10559652
负责人：
Yi Hong
金额：
$ 31.55万
依托单位：
UNIVERSITY OF TEXAS ARLINGTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10559652
关键词：
Acceleration Acrylates Address Adhesions Adhesives Affect Age Aging Alginates Animal Model Anterior Apical Attenuated Bladder Cells Cervix Uteri Chemical Structure Clinic Cost Savings Data Defect Development Disease Drops Dyspareunia Effectiveness Environment FDA approved Family suidae Fibrin Fibrin Tissue Adhesive Functional disorder Glues Goals Growth Implant In Vitro Infective cystitis Injectable Intestines Life Mechanics Methodology Modeling Morbidity - disease rate Muscle Mussels Notification Operative Surgical Procedures Outcome Pain Patients Pelvic floor structure Pelvis Pessaries Polymers Prevention Prevention strategy Preventive Preventive treatment Property Ptosis Quality of life Rattus Rectum Recurrence Repeat Surgery Safety Sheep Silicon Dioxide Skin Smooth Muscle Myocytes Surface Surgical incisions Symptoms System Testing Time Tissue Model Tissues Treatment Cost Uterus Vagina Woman Work abdominal wall adhesive polymer biodegradable polymer biomaterial compatibility care costs chemokine cost crosslink cytotoxicity design effectiveness evaluation efficacy evaluation experience fabrication healing improved in vivo innovation interest middle age nanoparticle novel novel strategies older women pelvic organ prolapse pressure prevent procedure cost recruit rectal repaired replacement tissue safety assessment stem cells symptomatology tissue glueing tissue regeneration translational applications wound wound healing

项目摘要

Project summary Early vaginal wall detachment often results in pelvic organ prolapse (POP). POP is a common disease in the aging woman with a high morbidity rate related to treatment. Approximately 30-40% of women may experience this condition, and by 80 years-old about 20% or so will need to undergo corrective surgery. However, current synthetic materials for corrective surgery have been popular but can lead to severe complications as recognized by the FDA in two notifications (2008, 2011) along with a high prolapse recurrence rate. Furthermore, the POP treatment is delayed until advanced stages due to late recognition and variable symptomatology. To reduce POP morbidity and treatment cost, a strategy to address early vaginal wall detachment to prevent POP development would be highly desirable. Such a preventive treatment could employ an appropriate biodegradable bio-adhesive material to reattach the detached vaginal wall to the pelvic muscle in order to prevent further drop and detachment of the anterior vaginal wall and vaginal apex resulting in POP. Our preliminary work indicates that a biodegradable mussel-inspired adhesive is a good candidate to attain this preventive goal, but it needs further improvement in adhesive strength properties and tissue durability. In this project, our goal is to develop a novel adhesive material from mussel-inspired adhesive and biodegradable nanoparticles specific for early vaginal wall detachment. To realize this goal, three specific aims are proposed. In Aim 1, we will prepare and optimize our current biodegradable nanoblend adhesive by altering its chemical structure, component concentrations, nanoparticle contents and surface. In Aim 2, we will evaluate the adhesive strength of the nanoblend using an ex vivo tissue model and assess the material biosafety, adhesive strength and tissue growth in vivo using a rat model. In Aim 3, we will incorporate a cell recruiting chemokine into the adhesive, which can recruit stem cells to promote new tissue formation to permanently enhance the attachment between pelvic floor and muscle. We will further determine the efficacy of this bioactive adhesive using a rat model. Three innovative aspects are proposed. The first is the novel concept of prevention strategy to manage early vaginal wall detachment to reduce the morbidity of POP, which can improve the life quality of the women patients and save therapy costs. The second is the implementation of a novel biodegradable adhesive material system. It will provide rapid and robust adhesive to reinforce the detached vaginal wall from the pelvic muscle, and allow new tissue ingrowth. The nanoparticles can increase the adhesive strength and also served as carriers to deliver biofunctional molecules. The third is that this nanoblend adhesive can also works for cell recruitment and tissue regeneration. The successful outcome of this project will provide a novel strategy to treat patients with early vaginal wall detachment to prevent POP occurrence, thus resulting in reduced morbidity and associated treatment cost. The developed materials and methodologies could be used for other biomedical applications such as tissue glue and wound healing.

项目摘要早期阴道壁脱离常导致盆腔器官脱垂（POP）。POP是一种常见的疾病，老年妇女发病率高与治疗有关。大约30-40%的女性可能会经历这种情况下，到80岁时，大约20%左右的人需要接受矫正手术。但目前的用于矫正手术的合成材料已经很流行，但可能导致严重的并发症，沿着高脱垂复发率，FDA在两份通知（2008年，2011年）中认可了该疾病。此外，POP治疗由于识别晚和变量而延迟到晚期。医学。为了降低POP发病率和治疗费用，最好能保持独立，防止持久性有机污染物的发展。这种预防性治疗可以采用适当的可生物降解的生物粘合材料，以将分离的阴道壁重新附着到骨盆肌肉上以防止阴道前壁和阴道尖进一步下降和脱离而导致POP。我们的初步工作表明，可生物降解的贻贝启发粘合剂是一个很好的候选人，以实现这一点预防目标，但它需要进一步改善粘合强度性能和组织耐久性。在这项目，我们的目标是开发一种新型的粘合剂材料从贻贝启发的粘合剂和生物降解对早期阴道壁脱落有特异性的纳米颗粒。为实现这一目标，提出了三个具体目标。在目标1中，我们将通过改变其化学组成来制备和优化我们目前的可生物降解纳米粘合剂，结构、组分浓度、纳米颗粒含量和表面。在目标2中，我们将评估使用离体组织模型测定纳米条的粘附强度，并评估材料的生物安全性、粘附性强度和组织生长。在目标3中，我们将加入细胞募集趋化因子粘合剂，它可以招募干细胞，促进新组织的形成，以永久增强骨盆底和肌肉之间的附着。我们将进一步确定这种生物活性粘合剂的功效使用老鼠模型。提出了三个创新点。首先是预防战略的新颖概念早期处理阴道壁脱离，降低POP的发生率，提高患者的生活质量减少了女性患者的痛苦，节省了治疗费用。二是实施一种新型的生物降解胶粘材料体系它将提供快速和坚固的粘合剂，以加强脱落的阴道壁，骨盆肌肉，并允许新的组织长入。纳米颗粒可以增加粘合强度，也用作递送生物功能分子的载体。第三，这种纳米粘合剂还可以对细胞募集和组织再生起作用。该项目的成功成果将提供一个新的治疗早期阴道壁脱离患者以预防POP发生的策略，从而导致降低发病率和相关的治疗费用。所开发的材料和方法可用于用于其他生物医学应用，例如组织胶和伤口愈合。