Computational Core
计算核心
基本信息
- 批准号:10569666
- 负责人:
- 金额:$ 13.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-03-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressArtificial IntelligenceBasic ScienceBiologyBiomedical ResearchCenters of Research ExcellenceChemicalsClinicalClinical ResearchComplementComplexComputer HardwareComputer softwareComputing MethodologiesConsultationsDNAData AnalysesDevelopmentDevicesDiffusionDiseaseDoctor of PhilosophyExcretory functionFacultyGoalsGoldHealthIndividualInfrastructureKentuckyLeadLeadershipLigandsMacromolecular ComplexesMentorsMentorshipMetabolismMethodsModelingMolecularMolecular MedicineOrganic SynthesisPharmacologic SubstanceProcessProteinsProtocols documentationResearchResearch DesignResearch PersonnelResearch SupportResourcesScienceScientistServicesStructureTechniquesToxic effectTrainingTranslational ResearchUniversitiesValidationabsorptioncareer developmentclinical applicationdesignexperimental studyfaculty researchinnovationintermolecular interactionmodels and simulationmolecular dynamicsmolecular modelingmultidisciplinarynanoparticleparticlepre-clinicalpreventprimary outcomeprotein complexresearch facultyself assemblysimulationstemsynergismtoolvirtual screening
项目摘要
PROJECT SUMMARY/ABSTRACT – COMPUTATIONAL CORE
We propose to establish a Center of Biomedical Research Excellence (COBRE) in Pharmaceutical Research
and Innovation at the University of Kentucky (UK). CPRI will serve as a comprehensive multidisciplinary center
focused on translational chemical biology [the nexus of chemical biology (the application of chemical biology
principles to develop validated probe/models to advance our understanding of biology) and pharmaceutical
science (the application of pharmaceutical principles to advance leads/materials/devices that address unmet
clinical needs)]. The COBRE will leverage and develop unique translational chemical biology research support
infrastructure/expertise to facilitate junior faculty mentorship and career development, innovative biomedical
research probe/tool/model/materials development and validation, and the early advancement of potential
‘translatable’ assets. Within this context, the CPRI Computational Core, directed by Dr. Chang-Guo Zhan, will
leverage unique computational expertise, commercial and in-house software/methods, and UK’s formidable
computational processing network to support a range of computational services to advance COBRE project and
pilot objectives. The Core will provide services individually tailored to project/pilot needs that facilitate the
development of new hypotheses/models and streamline the prioritization of experimental studies. Specifically,
the Core will enable molecular modeling/simulation of macromolecular targets and target-ligand complexes,
ADMET prediction studies, structure-based virtual screening for ligand discovery, de novo ligand design, and
artificial intelligence-based methods. This suite of services has been strategically designed to integrate with, and
complement, the support provided by the CPRI Translational Core and the CPRI-affiliated COBRE for Molecular
Medicine Organic Synthesis Core. Together, CPRI’s corresponding fully integrated suite of research support
capabilities and expertise will accelerate innovative preclinical translational research and facilitate junior
investigator career development.
项目摘要/摘要-计算核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CHANG-GUO ZHAN其他文献
CHANG-GUO ZHAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CHANG-GUO ZHAN', 18)}}的其他基金
Long-acting aldicarb hydrolase as a medical countermeasure for aldicarb poisoning
长效涕灭威水解酶作为涕灭威中毒的医学对策
- 批准号:
10724752 - 财政年份:2023
- 资助金额:
$ 13.01万 - 项目类别:
Effects of HIV-1 Tat protein and methamphetamine on VMAT2-mediated dopamine transmission in the context of neuroHIV and drug abuse
HIV-1 Tat 蛋白和甲基苯丙胺对神经 HIV 和药物滥用背景下 VMAT2 介导的多巴胺传递的影响
- 批准号:
10698618 - 财政年份:2023
- 资助金额:
$ 13.01万 - 项目类别:
Ghrelin Deacylase as a Treatment for Opioid Polysubstance Abuse
生长素释放肽脱酰酶治疗阿片类多物质滥用
- 批准号:
10510245 - 财政年份:2022
- 资助金额:
$ 13.01万 - 项目类别:
Development of a Long-acting Enzyme Therapy for Treatment of Cocaine Abuse
开发治疗可卡因滥用的长效酶疗法
- 批准号:
10405101 - 财政年份:2020
- 资助金额:
$ 13.01万 - 项目类别:
Development of a Long-acting Enzyme Therapy for Treatment of Cocaine Abuse
开发治疗可卡因滥用的长效酶疗法
- 批准号:
10231091 - 财政年份:2020
- 资助金额:
$ 13.01万 - 项目类别:
Development of Long-acting Cocaine Hydrolase as a Treatment for Cocaine Abuse
开发长效可卡因水解酶来治疗可卡因滥用
- 批准号:
9754089 - 财政年份:2015
- 资助金额:
$ 13.01万 - 项目类别:
Development of Long-acting Cocaine Hydrolase as a Treatment for Cocaine Abuse
开发长效可卡因水解酶来治疗可卡因滥用
- 批准号:
9139953 - 财政年份:2015
- 资助金额:
$ 13.01万 - 项目类别:
Long-lasting cocaine-metabolizing enzyme for cocaine addiction treatment
用于可卡因成瘾治疗的长效可卡因代谢酶
- 批准号:
8636423 - 财政年份:2013
- 资助金额:
$ 13.01万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 13.01万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 13.01万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 13.01万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 13.01万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 13.01万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 13.01万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 13.01万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 13.01万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 13.01万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 13.01万 - 项目类别:
Research Grant