Structural and Functional Studies of Mtr4 and the TRAMP RNA Surveillance Complex

Mtr4 和 TRAMP RNA 监视复合体的结构和功能研究

基本信息

  • 批准号:
    10580424
  • 负责人:
  • 金额:
    $ 43.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-10 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

Project Summary Nuclear RNA processing and surveillance is a complex process involving multiple proteins and protein assemblies that identify and eventually degrade targeted RNA substrates. The RNA helicase, Mtr4, plays a central role in this process by providing a bridge between substrate targeting and RNA decay by the RNA exosome. RNA recognition is performed directly by Mtr4 and by various adaptor proteins that recruit Mtr4 to targeted substrates. A major challenge is to understand the molecular details of how these proteins interact with RNA substrates and with each other to achieve substrate specificity. Additionally, accessory domains within Mtr4 play important but poorly defined roles in substrate recognition and processing. Notably, the available structural data demonstrate that Mtr4 is a highly dynamic protein, but it is not known how protein dynamics relate to helicase function. This project seeks to define the molecular basis for Mtr4 function by employing a variety of biochemical, biophysical and structural approaches, supported by in vivo genetic analyses. The specific aims of this project are to (1) describe the role of Mtr4 accessory domains and (2) characterize interactions within the TRAMP (Trf4-Air2-Mtr4) complex. Undergraduate and graduate researchers with interests in future careers in biomedical research or medicine will be involved in the project.
项目总结

项目成果

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SEAN J JOHNSON其他文献

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{{ truncateString('SEAN J JOHNSON', 18)}}的其他基金

Administrative Supplement for Equipment Purchase
设备采购行政补充
  • 批准号:
    10795516
  • 财政年份:
    2022
  • 资助金额:
    $ 43.01万
  • 项目类别:
Structural and Functional Studies of Mtr4 and Mtr4-mediated Complexes
Mtr4 和 Mtr4 介导的复合物的结构和功能研究
  • 批准号:
    9009671
  • 财政年份:
    2015
  • 资助金额:
    $ 43.01万
  • 项目类别:
Structural and Functional Studies of Mtr4 and Mtr4-mediated Complexes
Mtr4 和 Mtr4 介导的复合物的结构和功能研究
  • 批准号:
    9152810
  • 财政年份:
    2015
  • 资助金额:
    $ 43.01万
  • 项目类别:
Structural and Functional Studies of Mtr4 and Mtr4-mediated Complexes
Mtr4 和 Mtr4 介导的复合物的结构和功能研究
  • 批准号:
    9319568
  • 财政年份:
    2015
  • 资助金额:
    $ 43.01万
  • 项目类别:
STRUCTURAL STUDIES OF MTR4
MTR4 的结构研究
  • 批准号:
    8362287
  • 财政年份:
    2011
  • 资助金额:
    $ 43.01万
  • 项目类别:
STRUCTURAL STUDIES OF MTR4
MTR4 的结构研究
  • 批准号:
    8170288
  • 财政年份:
    2010
  • 资助金额:
    $ 43.01万
  • 项目类别:
Structural Studies of Spt6
Spt6的结构研究
  • 批准号:
    7038321
  • 财政年份:
    2005
  • 资助金额:
    $ 43.01万
  • 项目类别:
Structural Studies of Spt6
Spt6的结构研究
  • 批准号:
    6937306
  • 财政年份:
    2005
  • 资助金额:
    $ 43.01万
  • 项目类别:

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