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Novel Transparent, Ultra-soft Neuroelectrode Arrays Based on Nanomeshing Conventional Electrode Materials SUPPLEMENT

基于纳米网格的新型透明、超软神经电极阵列传统电极材料补充

基本信息

批准号：
10579663
负责人：
Michela Fagiolini
金额：
$ 23.46万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2023-08-31
项目状态：
已结题

项目摘要

Abstract The objective of our parent award RF1NS118301 is to develop and validate proof-of-concept, nanomesh- microelectrode-based, transparent, ultra-soft, high-density (NANOMESH) array with at least 256 high-performance nanomesh microelectrodes and artifact rejecting wireless data link. The proposed dissemination supplement is within the scope of the parent award, but beyond the original dissemination plans. As the focus of the parent award is to generate proof-of-concept for NANOMESH arrays, we decided at the time when applying for our parent award that a plan for dissemination of proposed technology in it may be premature. Over the past project duration, PI Fang’s lab has established the fabrication and testing of flexible nanomesh microelectrode arrays (MEAs) with up to 256-ch in wired connections. Although the parent award aims to achieve also ultra-softness for the arrays in addition to fully wireless system, wire-connected nanomesh MEAs are still highly useful and particularly suitable for electrophysiology applications with concurrent in vivo imaging, where the animals are going to be head-fixed anyway. This dissemination will not only fulfill some urgent needs in the community for such electrode arrays, it will also in turn, provide valuable feedback on both the further technology development and how to best disseminate novel neuroelectronic devices. Consequently, we feel it’s appropriate to pursue small dissemination efforts of our existing and/or easily-achievable wired, soft nanomesh MEAs, which will significantly benefit three end-user laboratories, while being highly synergistic with the parent award. This grant supplement will significantly facilitate the intended small dissemination efforts by (1) providing two pieces of equipment that will scale-up and automate the device fabrication process of soft nanomesh MEAs, (2) purchasing materials and supplies for building additional devices, (3) supporting research assistants in the PI’s lab to conduct training on the soft nanomesh MEAs being disseminated and their handling/utilization, and (4) supplying dedicated recording systems for one of our end-users for chronic experiments.

摘要我们的母公司奖项RF 1 NS 118301的目标是开发和验证概念验证，纳米网，基于微电极的透明超软高密度（NANOMESH）阵列，具有至少256个高性能纳米网微电极和伪像排除无线数据链路。拟议传播补充是在母奖的范围内，但超出了原来的传播计划。由于母公司奖项的重点是为NANOMESH阵列生成概念验证，因此我们决定在在申请我们的母公司奖时，可能会有一个传播拟议技术的计划，早产在过去的项目期间，PI Fang的实验室已经建立了灵活的制造和测试，纳米网微电极阵列（MEA），有线连接高达256通道。虽然父母奖旨在实现超软的阵列，除了完全无线系统，有线连接纳米网MEA仍然是非常有用的，并且特别适用于电生理学应用，同时进行体内成像，动物的头部无论如何都会被固定。这种传播不会这不仅满足了社区对这种电极阵列的一些迫切需求，关于进一步技术发展和如何最好地传播新的神经电子装置.因此，我们认为这是适当的追求小的传播努力，我们现有的和/或易于实现的有线软纳米网MEA，这将大大有利于三个最终用户实验室，与家长奖高度协同。这一补助金补充将通过以下方式大大促进预期的小型传播工作：（1）提供两件设备，将扩大和自动化软纳米网的设备制造过程多边环境协定，（2）购买材料和用品，以建立额外的设备，（3）支持研究助理在PI的实验室进行培训的软纳米网多边环境协定正在传播和他们的处理/利用，以及（4）为我们的最终用户之一提供专用记录系统，用于长期实验