Novel Transparent, Ultra-soft Neuroelectrode Arrays Based on Nanomeshing Conventional Electrode Materials SUPPLEMENT

点击翻译按钮获取中文摘要

Abstract The objective of our parent award RF1NS118301 is to develop and validate proof-of-concept, nanomesh- microelectrode-based, transparent, ultra-soft, high-density (NANOMESH) array with at least 256 high-performance nanomesh microelectrodes and artifact rejecting wireless data link. The proposed dissemination supplement is within the scope of the parent award, but beyond the original dissemination plans. As the focus of the parent award is to generate proof-of-concept for NANOMESH arrays, we decided at the time when applying for our parent award that a plan for dissemination of proposed technology in it may be premature. Over the past project duration, PI Fang’s lab has established the fabrication and testing of flexible nanomesh microelectrode arrays (MEAs) with up to 256-ch in wired connections. Although the parent award aims to achieve also ultra-softness for the arrays in addition to fully wireless system, wire-connected nanomesh MEAs are still highly useful and particularly suitable for electrophysiology applications with concurrent in vivo imaging, where the animals are going to be head-fixed anyway. This dissemination will not only fulfill some urgent needs in the community for such electrode arrays, it will also in turn, provide valuable feedback on both the further technology development and how to best disseminate novel neuroelectronic devices. Consequently, we feel it’s appropriate to pursue small dissemination efforts of our existing and/or easily-achievable wired, soft nanomesh MEAs, which will significantly benefit three end-user laboratories, while being highly synergistic with the parent award. This grant supplement will significantly facilitate the intended small dissemination efforts by (1) providing two pieces of equipment that will scale-up and automate the device fabrication process of soft nanomesh MEAs, (2) purchasing materials and supplies for building additional devices, (3) supporting research assistants in the PI’s lab to conduct training on the soft nanomesh MEAs being disseminated and their handling/utilization, and (4) supplying dedicated recording systems for one of our end-users for chronic experiments.