Crosstalk in Polymer Microelectrode Arrays.
Crosstalk in Polymer Microelectrode Arrays.
复制标题
聚合物微电极阵列中的串扰。
DOI：
10.1007/s12274-021-3442-8
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发表时间：
2021-09
期刊：
影响因子：
9.9
通讯作者：
Fang H
中科院分区：
文献类型：
--
作者：
Qiang Y;Gu W;Liu Z;Liang S;Ryu JH;Seo KJ;Liu W;Fang H
薄膜聚合物微电极阵列(MEAs)以其优异的机械柔顺性为高分辨率神经记录提供了便利。然而，密集排列的电极和互连以及超薄的聚合物封装/衬底层会引起不可忽略的串扰，这可能会导致对神经信号记录的严重干扰。由于神经电极阵列中的串扰缺乏标准化的表征或建模，到目前为止，聚合物MEA中的串扰仍然知之甚少。在这项工作中，实验测量了相邻两个聚合物微电极之间的串扰，并使用等效电路对其进行了建模。重要的是，这项研究展示了一个双孔测量平台，并系统地表征了聚合物微电极中的串扰，真正隔离了受扰通道，并精确控制了其接地条件。从详细的电路模型出发，提出了一个简单、统一的方程来计算不同环境下的串扰。进一步进行了有限元分析，以探索更大尺寸的聚合物电极丝中的串扰。除了标准化神经电极阵列的串扰特性外，本研究不仅揭示了聚合物MEA中的串扰与各种关键器件参数的依赖关系，而且还为设计用于高质量神经信号记录的薄聚合物MEA提供了一般性的指导。
Thin-film polymer microelectrode arrays (MEAs) facilitate the high-resolution neural recording with its superior mechanical compliance. However, the densely packed electrodes and interconnects along with the ultra-thin polymeric encapsulation/substrate layers give rise to non-negligible crosstalk, which could result in severe interference in the neural signal recording. Due to the lack of standardized characterization or modeling of crosstalk in neural electrode arrays, to date, crosstalk in polymer MEAs remains poorly understood. In this work, the crosstalk between two adjacent polymer microelectrodes is measured experimentally and modeled using equivalent circuits. Importantly, this study demonstrated a two-well measuring platform and systematically characterized the crosstalk in polymer microelectrodes with true isolation of the victim channel and precise control of its grounding condition. A simple, unified equation from detailed circuit modeling was proposed to calculate the crosstalk in different environments. Finite element analysis (FEA) analysis was conducted further to explore the crosstalk in more aggressively scaled polymer electrode threads. In addition to standardizing neural electrode array crosstalk characterization, this study not only reveals the dependence of the crosstalk in polymer MEAs on a variety of key device parameters but also provides general guidelines for the design of thin polymer MEAs for high-quality neural signal recording.
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