Bridging the micro and macro scales of seizure dynamics
连接癫痫动力学的微观和宏观尺度
基本信息
- 批准号:10574151
- 负责人:
- 金额:$ 7.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAntiepileptic AgentsAreaBehaviorBiological MarkersBrainBrain imagingCharacteristicsClinicalComplexDataData CollectionElectrodesElectroencephalographyElectrophysiology (science)EpilepsyExcisionExhibitsFellowshipFreedomFrequenciesFutureGoalsHigh Frequency OscillationImplantImplanted ElectrodesIntractable EpilepsyLeadMeasurementMeasuresMethodsMicroelectrodesModelingNatureNeurosciencesOperative Surgical ProceduresOutcomePatient-Focused OutcomesPatientsPatternPeriodicityPharmaceutical PreparationsPhasePhysiologicalPositioning AttributeProceduresPropertyQuality of lifeReportingResolutionSeizuresSourceStructureTestingTimeTissuesTravelVariantWorkbrain electrical activitybrain tissuechildhood epilepsydensitydesignimprovedimproved outcomemathematical modelmillimeterparent grantspatiotemporaltemporal measurementtwo-dimensional
项目摘要
PROJECT SUMMARY/ABSTRACT
In the most severe cases of epilepsy, where seizures persist despite multiple trials of anti-seizure medications,
patients may benefit from surgical removal of seizure-generating brain tissue. Prior to surgery, electrodes are
often implanted directly into or onto the patient’s brain and are used to continuously record electrical brain
activity over days. Ideally, this enables clinicians to capture seizure activity and determine its point of origin.
Then this information is used in combination with the results of brain imaging and other testing to guide
removal of brain tissue. While epilepsy surgery may lead to seizure freedom, 70-90% of surgery patients
remain on anti-seizure medications and roughly 50% of patients continue to have seizures. The fact that
seizures often persist after such a drastic, invasive procedure indicates that current methods for localization of
seizure-generating tissue are insufficient. Therefore, the long-term goal of this work is to improve the outcomes
of patients undergoing epilepsy surgery by developing more accurate methods to localize seizure-generating
tissue. However, in order to achieve accurate, patient-specific seizure localization and successful surgery,
there is a critical need to understand how seizures start and spread. Many studies have reported
electrophysiological characteristics of seizures, and these vary depending on the spatial scale at which they
are measured. Microelectrode arrays provide cellular-level electrophysiological detail, but only within a 4mm x
4mm area on a single gyrus. Standard clinical macroelectrodes provide broader spatial coverage, but they lack
the spatial resolution to accurately track seizure dynamics, leading to highly variable estimates of wave
sources and directions. Moreover, when measured at these two disparate scales, characteristics of the
complex electrical activity that occurs during a seizure can appear contradictory in nature. Therefore, a
significant barrier to our understanding of seizures is our inability to bridge the micro and macro spatial scales.
To address this, the overall objective of this proposal is to quantify and model seizure dynamics at an
intermediate spatial scale with high spatial and temporal resolution. The rationale is that this will unify our
understanding of seizure onset and spread across different spatial scales, ultimately improving our ability to
localize seizures and surgically treat epilepsy. To attain the overall objective, we will record seizures in patients
with refractory epilepsy using high-density subdural grids. Using this data, we will pursue the following specific
aims: (1) Quantify mesoscale cortical dynamics of seizure onset and spread. (2) Develop a mesoscale
mathematical model of non-uniform seizure wave propagation. Completion of these aims will provide an
unprecedented view of seizure dynamics at the millimeter scale, bridging the gap in spatial scales of existing
studies. This will have a positive impact by providing a more detailed understanding of how seizures start and
propagate, which has the potential to inform epilepsy surgical planning. This will lead to a greater chance of
seizure freedom and improved quality of life for patients with the most severe cases of epilepsy.
项目总结/文摘
项目成果
期刊论文数量(0)
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Beth Ann Lopour其他文献
Beth Ann Lopour的其他文献
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{{ truncateString('Beth Ann Lopour', 18)}}的其他基金
Seizure localization for epilepsy surgery using high frequency electrophysiological markers
使用高频电生理标记进行癫痫手术的癫痫发作定位
- 批准号:
10368114 - 财政年份:2021
- 资助金额:
$ 7.55万 - 项目类别:
Seizure localization for epilepsy surgery using high frequency electrophysiological markers
使用高频电生理标记进行癫痫手术的癫痫发作定位
- 批准号:
10211944 - 财政年份:2021
- 资助金额:
$ 7.55万 - 项目类别:
Seizure localization for epilepsy surgery using high frequency electrophysiological markers
使用高频电生理标记进行癫痫手术的癫痫发作定位
- 批准号:
10570953 - 财政年份:2021
- 资助金额:
$ 7.55万 - 项目类别:
Seizure localization for epilepsy surgery using high frequency electrophysiological markers
使用高频电生理标记进行癫痫手术的癫痫发作定位
- 批准号:
10606373 - 财政年份:2021
- 资助金额:
$ 7.55万 - 项目类别:
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