Development of a Digital Cognitive Screening Test to detect Mild Cognitive Impairment and Dementia in Clinical Settings.

项目摘要 阿尔茨海默氏病和相关痴呆症是我们老龄化人口中日益严重的健康问题。 对认知功能进行评估以早期发现对于识别可能 受益于治疗与现有的对症药物治疗轻度痴呆症以及未来 正在积极开发并在临床研究中进行测试的疾病缓解疗法 审判目前的认知筛查工具很耗时，并且没有常规使用或记录在 忙碌的初级保健机构。因此，我们需要易于使用的工具，例如患者自我管理 措施，筛选个人在初级保健设置，以指导咨询，转诊和干预。 拟议的STTR第一阶段项目旨在开发和测试一种创新的数字认知筛查方法， RIMCAT（罗得岛移动的认知评估工具），用于识别轻度认知障碍 老年痴呆症和老年痴呆症。RIMCAT由10个组件组成， 自我管理的监督设置，如初级保健的做法，并提供了一个认知友好 界面允许语音输入、键盘输入和易于理解的指令。这个目标 STTR项目旨在通过心理测量学的方法检验RIMCAT的初步信度和效度。的 该项目还包括开发一个数字健康框架，以支持 MCI/痴呆筛查。要求这笔补充资金是为了满足意外需要， 容纳额外的40名参与者（由评审员建议），以准备远程研究中心， 罗得岛，并扩大数字健康框架。

Project Summary Alzheimer’s disease and related dementias are a growing health problem in our aging population. Assessment of cognitive functioning for early detection is critical to identify individuals who might benefit from treatment with the available symptomatic medications for mild dementia as well as future disease-modifying therapies that are actively under development and being tested in clinical research trials. Current cognitive screening tools are time-consuming and not routinely used or documented in busy primary care settings. As a result, we need easily accessible tools, such as patient self-administered measures, to screen individuals in primary care settings to guide counseling, referrals, and interventions. The proposed STTR Phase I project aims to develop and test an innovative digital cognitive screening instrument, RIMCAT (Rhode Island Mobile Cognitive Assessment Tool) to identify mild cognitive impairment and dementia in older adults. RIMCAT consists of 10 components and was designed for self-administration in supervised settings such as primary care practices and provides a cognitive-friendly interface allowing voice inputs, keyboard typing, and easy-to-understand instructions. The goal of this STTR project is to examine the initial reliability and validity of RIMCAT through a psychometric study. The project also includes the development of a digital health framework to support the workflow of MCI/dementia screening. This supplementary fund is requested to meet the unanticipated needs to accommodate the additional 40 participants (suggested by reviewers), to prepare remote study sites in Rhode Island, and to scale the digital health framework.