Equipment Supplement to 1R01GM141391-01A1 (Easily Used Kits to Evolve Reagents that Covalently Tag and Inactivate Proteins)

1R01GM141391-01A1的设备补充 (易于使用的试剂盒，用于进化共价标记和灭活蛋白质的试剂) 应用分子进化基础 史蒂文·本纳 摘要 应用分子进化基金会(FfAME)拥有最新的NIGMS R01研究 获奖(R01GM141391，易于使用的试剂盒，用于进化共价标记和灭活的试剂 蛋白质)。根据这项奖励，FfAME正在申请补充设备资金，这将是 用于取代已有16年历史的BioRad PMI磷成像仪，该仪器用作 R01项目的主力。 受资助的R01赠款的主要目标是利用FfAME的人工扩展遗传 Alphabet(宙斯盾)开发一个平台，按需创建受体、配体和催化剂。 这些分子可以用来共价修饰、标记和破坏蛋白质，这些蛋白质由 研究人员和临床医生针对和解决许多科学、诊断和疾病 管理问题。 这一行政补充，如果获得批准，将促进购买一辆amersham 台风生物分子成像仪将取代BioRad PMI并发挥关键作用 为资助的R01项目的成功而努力。

Equipment Supplement for 1R01GM141391-01A1 (Easily Used Kits to Evolve Reagents that Covalently Tag and Inactivate Proteins) Foundation for Applied Molecular Evolution Steven Benner Abstract The Foundation for Applied Molecular Evolution (FfAME) holds a current NIGMS R01 research award (R01GM141391, Easily Used Kits to Evolve Reagents that Covalently Tag and Inactivate Proteins). Under this award, FfAME is requesting supplemental equipment funds that will be used to replace a 16-year-old BioRad PMI phosphorimager, an instrument that serves as the workhorse for the R01 project. The main goal of the funded R01 grant is to utilize FfAME’s artificially expanded genetic alphabet (AEGIS) to develop a platform to create receptors, ligands, and catalysts on demand. These molecules can be used to covalently modify, tag, and destroy proteins that are chosen by researchers and clinicians to target and solve many scientific, diagnostics, and disease management problems. This administrative supplement, if granted, will facilitate the purchase of an Amersham Typhoon Biomolecular Imager, which will replace the BioRad PMI and will serve a critical role in the success of the funded R01 project.