Equipment Supplement to 1R01GM141391-01A1 (Easily Used Kits to Evolve Reagents that Covalently Tag and Inactivate Proteins)

1R01GM141391-01A1 的设备补充（易于使用的试剂盒，用于进化共价标记和灭活蛋白质的试剂）

• 批准号: 10580301
• 负责人: STEVEN A BENNER
• 金额: $ 13.5万
• 依托单位: FOUNDATION FOR APPLIED MOLECULAR EVOLUTN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10580301
• 关键词: 16 year old; Administrative Supplement; Award; Diagnostic; Disease Management; Equipment; Foundations; Funding; Genetic; Goals; Grant; Ligands; Molecular Evolution; National Institute of General Medical Sciences; Proteins; Reagent; Research; Research Personnel; Role; U-Series Cooperative Agreements; United States National Institutes of Health; catalyst; equipment acquisition; imager; instrument; interest; receptor; repaired; response; success

Equipment Supplement for 1R01GM141391-01A1 (Easily Used Kits to Evolve Reagents that Covalently Tag and Inactivate Proteins) Foundation for Applied Molecular Evolution Steven Benner Abstract The Foundation for Applied Molecular Evolution (FfAME) holds a current NIGMS R01 research award (R01GM141391, Easily Used Kits to Evolve Reagents that Covalently Tag and Inactivate Proteins). Under this award, FfAME is requesting supplemental equipment funds that will be used to replace a 16-year-old BioRad PMI phosphorimager, an instrument that serves as the workhorse for the R01 project. The main goal of the funded R01 grant is to utilize FfAME’s artificially expanded genetic alphabet (AEGIS) to develop a platform to create receptors, ligands, and catalysts on demand. These molecules can be used to covalently modify, tag, and destroy proteins that are chosen by researchers and clinicians to target and solve many scientific, diagnostics, and disease management problems. This administrative supplement, if granted, will facilitate the purchase of an Amersham Typhoon Biomolecular Imager, which will replace the BioRad PMI and will serve a critical role in the success of the funded R01 project.

1 R 01 GM 141391 - 01 A1设备补充 （易于使用的试剂盒，用于开发可标记和灭活蛋白质的试剂） 应用分子进化基金会 史蒂文·本纳 摘要 应用分子进化基金会（FfAME）目前正在进行NIGMS R 01研究。 奖项（R 01 GM 141391，易于使用的试剂盒，以开发可标记和灭活的试剂 蛋白质）。根据该合同，FfAME正在申请补充设备资金， 用于取代16岁的BioRad PMI磷光成像仪，该仪器用作 R 01项目的主力。 资助R 01赠款的主要目标是利用FfAME的人工扩增基因， Alphabet（AEGIS）开发了一个平台，可以根据需要创建受体、配体和催化剂。 这些分子可用于共价修饰，标记和破坏由蛋白质选择的蛋白质。 研究人员和临床医生的目标和解决许多科学，诊断和疾病， 管理问题。 这项行政补充，如果批准，将有助于购买一个阿默舍姆 Typhoon Biomolecular Imager将取代BioRad PMI，并将发挥关键作用 R 01项目的成功。