Administrative supplement to Duke G20 award

杜克大学G20奖的行政补充

基本信息

批准号：
10626469
负责人：
Colin S. Duckett
金额：
$ 326.48万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-23 至 2025-02-28
项目状态：
未结题

项目摘要

Project Summary/Abstract: The Duke Regional Biocontainment Laboratory (RBL) was constructed with funding from the National Institutes of Health (NIH) to support basic research necessary to develop drugs, diagnostics, and vaccines for emerging/reemerging infections and biodefense. The state-of-the-art biocontainment facility, designed to support lab and small animal research, was fully commissioned and opened for operation in 2007 on the Duke University Medical School Campus in Durham, NC. The Duke RBL facility supports grant/contract-funded investigators and also provides biocontainment labs, innovative host monitoring assays and small animal models through Core Service Center Units on a cost recovery basis. Fourteen years of use and time have rendered some of the Duke RBL facilities, systems and critical core research equipment obsolete, or in need of repair, replacement or modernization. Since award of the parent G20 we have identified additional critical deﬁciencies of the facility’s existing physical infrastructure that limit biosafety, security or threaten the provision of services it offers and research-related activities it supports. We will address these additional deficiencies through this supplement funding in our three original Specific Aims: 1) Modernize Building Control Systems – Replace and upgrade obsolete air compressor and the BACNet (Building Automation Control Network); 2) Modernize Biosafety and Security Systems - Replace aged/damaged PAPR units; and 3) Modernize Research Resources – Replace or add additional major equipment to the Duke RBL Research Service Cores - liquid handling automation equipment, ELISpot reader, next-generation Luminex reader, upgraded cell counter, replacement incubators, freezers and centrifuges, advanced fluorescence microscopy capability in BSL3, additional Allentown Biocontainment mouse caging, and live animal imaging with micro CT capability. These Aims/Goals will be accomplished by the highly integrated project management team assembled in the parent award with solid institutional support and trusted contractors/vendors that were part of the original design and construction of the facility.

项目摘要/摘要：杜克大学生物疗养实验室（RBL）是由国立研究所的资金建造的健康（NIH）支持开发药物，诊断和疫苗所必需的基础研究新兴/重新出现的感染和生物反应。旨在支持实验室和小型动物研究，并于2007年在杜克北卡罗来纳州达勒姆大学医学院校园。 Duke RBL设施支持赠款/合同资助调查人员，还提供生物内在实验室，创新的宿主监测测定法和小型动物模型通过核心服务中心单位以成本恢复为基础。使用和时间已经呈现了十四年一些杜克大学RBL设施，系统和关键的核心研究设备过时或需要维修，替代或现代化。自授予母公司G20以来，我们已经确定该设施现有的物理基础设施限制了生物安全，安全或威胁提供服务它支持的提供和与研究有关的活动。我们将通过此解决这些其他缺陷在我们的三个原始特定目的中补充资金：1）现代化建筑控制系统 - 更换和升级过时的空气压缩机和BACNET（建筑自动化控制网络）； 2）现代化生物安全和安全系统 - 更换老化/损坏的PAPR单位； 3）现代化研究资源 - 在Duke RBL研究服务核心 - 液体处理中更换或添加其他主要设备自动化设备，ELISPOT读取器，下一代Luminex读取器，升级的单元柜台，更换孵化器，冰柜和离心机，BSL3中的高级荧光显微镜能力，其他Allentown 生物疗法小鼠笼子和具有微CT功能的活动物成像。这些目标/目标将是由高度集成的项目管理团队完成的，由父母奖组成机构支持和值得信赖的承包商/供应商是原始设计和建设的一部分设施。