Administrative supplement to Duke G20 award

杜克大学G20奖的行政补充

• 批准号: 10626469
• 负责人: Colin S. Duckett
• 金额: $ 326.48万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626469
• 关键词: Address; Administrative Supplement; Air; Animal Experimentation; Animal Model; Automation; Award; Basic Science; Biological Assay; Cells; Computer Security; Containment; Contractor; Contracts; Diagnostic; Equipment; Facility Design and Construction; Facility Designs; Fluorescence Microscopy; Freezing; Funding; Goals; Grant; Incubators; Infection; Infrastructure; Laboratories; Laboratory Research; Liquid substance; Modernization; Monitor; Mus; Parents; Pharmaceutical Preparations; Reader; Recovery; Research; Research Personnel; Resources; Security; Service provision; Services; Solid; System; Time; Trust; United States National Institutes of Health; Universities; Vaccines; Vendor; aged; animal imaging; biocontainment facility; biodefense; cost; innovation; laboratory equipment; laboratory facility; medical schools; microCT; next generation; operation; repaired

Project Summary/Abstract: The Duke Regional Biocontainment Laboratory (RBL) was constructed with funding from the National Institutes of Health (NIH) to support basic research necessary to develop drugs, diagnostics, and vaccines for emerging/reemerging infections and biodefense. The state-of-the-art biocontainment facility, designed to support lab and small animal research, was fully commissioned and opened for operation in 2007 on the Duke University Medical School Campus in Durham, NC. The Duke RBL facility supports grant/contract-funded investigators and also provides biocontainment labs, innovative host monitoring assays and small animal models through Core Service Center Units on a cost recovery basis. Fourteen years of use and time have rendered some of the Duke RBL facilities, systems and critical core research equipment obsolete, or in need of repair, replacement or modernization. Since award of the parent G20 we have identified additional critical deficiencies of the facility’s existing physical infrastructure that limit biosafety, security or threaten the provision of services it offers and research-related activities it supports. We will address these additional deficiencies through this supplement funding in our three original Specific Aims: 1) Modernize Building Control Systems – Replace and upgrade obsolete air compressor and the BACNet (Building Automation Control Network); 2) Modernize Biosafety and Security Systems - Replace aged/damaged PAPR units; and 3) Modernize Research Resources – Replace or add additional major equipment to the Duke RBL Research Service Cores - liquid handling automation equipment, ELISpot reader, next-generation Luminex reader, upgraded cell counter, replacement incubators, freezers and centrifuges, advanced fluorescence microscopy capability in BSL3, additional Allentown Biocontainment mouse caging, and live animal imaging with micro CT capability. These Aims/Goals will be accomplished by the highly integrated project management team assembled in the parent award with solid institutional support and trusted contractors/vendors that were part of the original design and construction of the facility.

项目总结/文摘:

项目成果

A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice.

• DOI: 10.1128/jvi.00689-22
• 发表时间: 2022-08-10
• 期刊: Journal of virology
• 影响因子: 5.4

H3N2 influenza hemagglutination inhibition method qualification with data driven statistical methods for human clinical trials.

• DOI: 10.3389/fimmu.2023.1155880
• 发表时间: 2023
• 期刊: Frontiers in immunology
• 影响因子: 7.3

Targeted dose delivery of Mycobacterium tuberculosis in mice using silicon antifoaming agent via aerosol exposure system.

• DOI: 10.1371/journal.pone.0276130
• 发表时间: 2022
• 期刊: PloS one
• 影响因子: 3.7