Simian Vaccine Evaluation Unit: Operation of a Nonhuman Primate Breeding Colony

有效的HIV疫苗和其他预防策略的开发依赖于在临床前研究中使用非人灵长类动物（NHP）。为了满足这一需求，猿猴疫苗评估单位（SVEU）提供NHP资源，主要支持艾滋病疫苗和预防方式的临床前评估。SVEU计划将为NIAID提供使用NHP模型评估候选艾滋病疫苗的能力，在NHP模型中可以进行全身和粘膜免疫应答的全面评估，可以容易地测试疫苗效力，可以确定降低病毒获得风险的相关性，以及可以进行增强免疫原性和临床疫苗效力的方法。SVEU将为NIH支持的研究人员提供一个反应灵敏、灵活的疫苗资源，可以支持艾滋病疫苗研究的各个阶段，从候选艾滋病疫苗的临床前评估或临床试验，目的是确定一种能够产生免疫反应的疫苗，以预防或控制病毒感染。SVEU的工作范围包括为国家卫生机构提供住房和维持生活，开展研究以支持艾滋病预防研究，重点是艾滋病疫苗，支持国家卫生机构的繁殖群体，以及这些活动的一般行政和管理。

The development of effective HIV vaccines and other prevention strategies relies on the use of nonhuman primates (NHPs) in preclinical studies. To meet this need, the Simian Vaccine Evaluation Units (SVEUs) provide NHP resources that primarily support preclinical evaluation of AIDS vaccines and prevention modalities. The SVEU program will provide NIAID the ability to evaluate candidate AIDS vaccines using NHP models in which thorough evaluations of systemic and mucosal immune responses can be conducted, vaccine efficacy can easily be tested, correlates of reduced risk of virus acquisition can be identified, and approaches to enhance immunogenicity and efficacy of clinical vaccines can be conducted. The SVEUs will provide a responsive, flexible vaccine resource that is available to NIH-supported researchers and can support all stages of AIDS vaccine research, from preclinical evaluation or clinical testing of candidate AIDS vaccines, with the objective of identifying a vaccine that will generate immune responses able to prevent or control viral infection. The scope of the SVEUs includes housing and maintenance of NHPs, the conduct of studies supporting AIDS prevention research, with an emphasis on AIDS vaccines, support of a NHP breeding colony, and general administration and management of these activities.