Research methodology to assess surgery for ulnar neuropathy at the elbow

项目概要/摘要： 手肘尺神经病变（UNE）是第二常见的压迫性神经病变 腕管综合症之后男性的发病率是女性的三倍， 美国每年确诊的新病例。UNE不成比例地影响工作 特别是在需要长时间或频繁弯曲手肘的任务中。麻木 无名指和小指刺痛，手肘疼痛，手臂失去知觉， 手和无名指是UNE的特征性症状。严重的病例也可能有 手部肌肉的运动缺陷。诊断是基于体征，症状和电诊断 问题研究 UNE最常见的手术治疗是尺骨原位（简单）减压 手肘神经或皮下前神经移位。手术技术的选择 不同的外科医生，并没有明确的证据，关于哪个程序是更多的 对哪种类型的患者有效。 这项补充的父母补助金，尺神经手术（SUN）研究 （1U 01 AR 073485）是一项随机双盲优效性临床试验，旨在比较 原位减压和皮下前路移位术疗效评价 患者报告和生理结局。本补充建议提供一个例外 医学生（硕士培训）与实践培训和必要的技能，她， 追求学术生涯。具体来说，她将从中获得的学习和指导 经验将使她能够协助调查电诊断之间的关联 参数、种族/民族差异和与尺神经病变相关的治疗结果。 此外，本补编将提供关于上述专题的文献， 提高对UNE治疗中这些因素的认识。

Project Summary/Abstract: Ulnar neuropathy at the elbow (UNE) is the second most common compression neuropathy after carpal tunnel syndrome. It is three times more frequent in men than women with 73,000 new cases diagnosed in the United States each year. UNE disproportionately affects working individuals, particularly in tasks requiring prolonged or frequent flexion of the elbow. Numbness and tingling of the ring and little fingers, pain at the elbow, and loss of sensation over the arm, hand and ring fingers are the characteristic symptoms of UNE. Severe cases can also have motor deficit of the hand muscles. Diagnosis is based on signs, symptoms and electrodiagnostic studies. The most common surgical treatments for UNE are in-situ (simple) decompression of the ulnar nerve at the elbow or subcutaneous anterior nerve transposition. Choice of surgical technique differs among surgeons and there is no clear evidence regarding which procedure is more effective and for which type of patient. The parent grant for this supplement, the Surgery of the Ulnar Nerve (SUN) study (1U01AR073485) is a randomized double-blind superiority clinical trial to compare the effectiveness of in-situ decompression and subcutaneous anterior transposition by assessing patient-reported and physiologic outcomes. This supplement proposes to provide an exceptional medical student (with master’s training) with hands-on-training and skills necessary for her to pursue an academic career. Specifically, the learning and guidance she will gain from this experience will enable her to assist in investigating associations between electrodiagnostic parameters, racial/ethnic variations, and treatment outcomes related to ulnar neuropathy. Additionally, this supplement will contribute to literature on the above-mentioned topics and advance the understanding of these factors in UNE treatment.