Evidence-Based Research in Hand Surgery

描述（由申请人提供）：循证研究是依赖证据而不是观察的医疗实践的关键组成部分。然而，手外科领域的大多数治疗建议都依赖于证据水平低和研究设计不够严谨的研究。该K24应用程序致力于在密歇根大学开发多学科研究组合，通过应用流行病学和临床试验原则研究桡骨远端骨折的治疗。包括手外科、风湿病学、矫形外科、普通外科、流行病学和手疗法在内的多个学科将在这一提案中合作，开展临床试验和卫生服务研究，以获得指导治疗的数据。这项研究计划将包括一个指导计划，为初级外科教师，外科住院医生，国际研究员和医学生。该研究项目的主题是基于应用密歇根手部结局问卷（MHQ）来获得桡骨远端骨折管理的结局数据，这种情况每年困扰着60多万美国人。由于创伤和骨质疏松症，桡骨远端骨折影响美国人群的所有阶层。这是昂贵的美国医疗保健系统，尽管其描述超过200年前，这种伤害的治疗仍然笼罩着不确定性和争议。MHQ由PI在其Robert Wood约翰逊临床学者任期内开发，是美国和世界各地使用最广泛的手部结局问卷之一。这项研究工作将根据美国国立卫生研究院的路线图提出，以促进医生和科学家增加临床研究工作。K24申请的资金将加强手外科的临床研究，这是一个致力于在其研究议程中开发循证方法的专业。该奖项的资金还将为跨学科合作提供急需的研究支持，这不仅有利于手外科专业，而且还将加强与手部疾病治疗密切相关的其他专业的上肢疾病治疗。

DESCRIPTION (provided by applicant): Evidence-based research is a key component of medical practice that relies on evidence rather than: observations. However, most treatment recommendations in the field of hand surgery are dependent on; research with low levels of evidence and inadequate rigor in research design. This K24 application strives to develop a multidisciplinary research portfolio at the University of Michigan to study the treatment of distal; radius fracture by applying epidemiology and clinical trial principles. Various disciplines will collaborate in this proposal, including hand surgery, rheumatology, orthopaedic surgery, general surgery, epidemiology and hand therapy, to carry out clinical trials and health services research that will derive data to guide treatments. This research program will incorporate a mentoring program for junior surgery faculty, surgery residents, international fellows and medical students. The theme of this research project is based on applying the Michigan Hand Outcomes Questionnaire (MHQ) to obtain outcomes data in the management of distal radius fracture, a condition afflicting over 600,000 Americans each year. Distal radius fracture affects all strata of the US population due to trauma and osteoporosis. It is costly to the US health care system and despite its description over 200 years ago; the treatment for this injury is still clouded by uncertainty and controversy. The MHQ was developed by the PI during his Robert Wood Johnson Clinical Scholar's tenure and is one of the most widely used hand outcomes questionnaire in this country and around the world. This research effort will be presented based on the roadmap of the National Institutes of Health to foster increasing clinical research efforts by physician; scientists. The funding from this K24 application will enhance clinical research in hand surgery, a specialty that is working to develop an evidence-based approach in its research agenda. Funding from this award will also provide much needed research support for an interdisciplinary collaboration that will not only benefit the hand surgery specialty, but will also enhance the treatment of upper extremity conditions for other specialties that have intimate ties to the treatment of hand disorders.