Cannabis use patterns and associations with cognitive impairment in older adults

大麻使用模式以及与老年人认知障碍的关联

• 批准号: 10572279
• 负责人: Ofir Livne
• 金额: $ 19.54万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10572279
• 关键词: Acute; Address; Adult; Aging; Attention; Attitude; Benefits and Risks; Biometry; Brain; Cannabis; Clinical; Cognition; Cognitive; Consumption; Data; Data Analyses; Data Collection; Development; Development Plans; Elderly; Elements; Epidemiology; Feasibility Studies; Frequencies; Goals; Harm Reduction; Health; Health and Retirement Study; Heterogeneity; Impaired cognition; Impairment; Individual; Intervention; Intoxication; K-Series Research Career Programs; Linear Models; Longitudinal Studies; Measures; Mentors; Mentorship; Methods; Motivation; National Institute of Drug Abuse; Neurocognitive; Neuropsychology; Outcome; Pattern; Pilot Projects; Policy Maker; Population; Prevalence; Prevention strategy; Public Health; Recording of previous events; Records; Research; Research Personnel; Research Proposals; Residual state; Respondent; Risk; Route; Sampling; Self Administration; Short-Term Memory; Structure; Substance Use Disorder; Surveys; Therapeutic Intervention; Training; Training Programs; adolescent drug use; age group; aging population; baby boomer; cannabis use behavior; career; career development; causal model; cognitive function; cognitive testing; cohort; cost; cost effective; design; digital; digital tool; executive function; health data; insight; interest; longitudinal analysis; marijuana use; marijuana user; middle age; neuropsychiatric disorder; normal aging; novel; online delivery; preventive intervention; recruit; response; risk perception; secondary analysis; skills; social media; sociodemographics; substance use; substance use treatment; substance user; tool; trend

PROJECT SUMMARY/ABSTRACT Significance. Cannabis use is increasing exponentially among older US adults (≥65 years), a population that is expected to comprise over 20% of the population in coming decades. Older adults are particularly vulnerable to cognitive impairment associated with cannabis use, and demonstrate increasingly heterogeneous patterns of cannabis use (including cannabis use histories and current use profiles). Consequently, this rapidly growing population of cannabis users will become a public health concern in coming years and merit preventive and therapeutic interventions. Extant information on cannabis use patterns and their associations with cognitive impairment is lacking in this critically understudied population. This research proposal examines associations between a range of cannabis use measures and cognitive impairment, particularly residual impairment (i.e., cognitive effects observed after acute intoxication has passed), in older adult cannabis users. Career Development Plan. Dr. Livne’s training program will include coursework and mentorship to develop his skills and expertise in survey design, aging and cognition-related research, and generalized linear modeling, causal modeling and longitudinal analyses. These are necessary for achieving his career goals of becoming an independent investigator performing impactful research on the intersection between cannabis use, cognition, and the aging population. Mentorship. Dr. Livne’s will be supported by a highly accomplished team of mentors who are experts in substance use epidemiology, biostatistics, aging, and cognition. Research Plan. For Aim 1, Dr. Livne will use data from the Health and Retirement Study, a large nationally representative study of older US adults, to examine associations between cannabis use predictors and domain-specific cognitive impairment, including residual impairment, among adults ≥65 years. For Aim 2a, Dr. Livne will recruit a large online sample of older adults via social media platforms, to describe cannabis use patterns (i.e., cannabis use histories, current profiles of use) and examine the associations between such patterns. For Aim 2b, Dr. Livne will conduct a pilot study of a subset of respondents from the online sample as well as sociodemographically comparable older adults with no lifetime cannabis use. Using self-administered neuropsychological assessments, he will assess the feasibility of integrating cognitive tests in online samples of older adults and provide preliminary data on associations between detailed measures of cannabis use patterns and domain-specific residual cognitive impairment, expanding on analyses from Aim 1. Public Health Impact. This project will illuminate patterns of cannabis use and associated cognitive impairment among older adults, thus informing clinicians, researchers, and policymakers of individual and public health risks in a growing yet understudied cannabis user population. Subsequently, findings will inform the development of harm reduction strategies and the feasibility of utilizing online research tools for cost-effective cognitive assessment of older adult substance users.

项目概要/摘要 意义。美国老年人（≥65 岁）的大麻使用量呈指数级增长，这一人群 预计未来几十年将占人口的 20% 以上。老年人特别容易受到 与大麻使用相关的认知障碍，并表现出日益异质的模式 大麻使用（包括大麻使用历史和当前使用概况）。因此，这个快速增长的 大麻使用者人口将在未来几年成为公共卫生问题，值得预防和预防 治疗干预。关于大麻使用模式及其与认知的关系的现有信息 在这个研究严重不足的人群中，缺乏损伤。该研究提案考察了协会 一系列大麻使用措施与认知障碍，特别是残余障碍（即， 急性中毒过去后观察到的认知影响），在老年大麻使用者中。职业 发展计划。 Livne 博士的培训计划将包括课程作业和指导，以发展他的技能 以及调查设计、老龄化和认知相关研究以及广义线性模型、因果关系方面的专业知识 建模和纵向分析。这些对于实现他成为一名职业生涯目标是必要的。 独立调查员对大麻使用、认知、 和人口老龄化。指导。 Livne 博士将得到一支卓有成就的导师团队的支持 他们是药物滥用流行病学、生物统计学、衰老和认知方面的专家。研究计划。对于目标 1， Livne 博士将使用健康与退休研究的数据，这是一项针对美国老年人的全国性大型研究 成年人，检查大麻使用预测因素与特定领域认知障碍之间的关联， 包括 65 岁以上成年人的残余损伤。对于目标 2a，Livne 博士将招募大量在线样本 老年人通过社交媒体平台描述大麻使用模式（即大麻使用历史、当前 使用概况）并检查这些模式之间的关联。对于目标 2b，Livne 博士将进行试点 对在线样本中的一部分受访者以及社会人口统计学上具有可比性的老年人进行研究 终生不吸食大麻的成年人。通过自我管理的神经心理学评估，他将评估 将认知测试纳入老年人在线样本的可行性并提供初步数据 大麻使用模式的详细测量与特定领域的残余认知之间的关联 损害，扩展了目标 1. 公共卫生影响的分析。该项目将阐明以下模式： 老年人使用大麻和相关的认知障碍，从而告知临床医生、研究人员、 以及政策制定者对日益增长但尚未得到充分研究的大麻使用者群体的个人和公共卫生风险的关注。 随后，调查结果将为制定减少伤害战略和利用的可行性提供信息 对老年物质使用者进行具有成本效益的认知评估的在线研究工具。