Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU
Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU
批准号:
10570957
负责人:
Elizabeth Foglia
金额:
$21.43万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-02-11 至 2025-01-31
关键词:
AcademyAccident and Emergency departmentAdherenceAdultAdverse eventAirAmericanBlood gasCannulasCardiopulmonary ResuscitationCaringChildChildhoodComplexControl GroupsCritical IllnessDataDevelopmentEmergency SituationEnsureEvaluationEventFundingFutureGestational AgeHeart RateHumanHyperoxiaHypoxiaInfantInformed ConsentIntensive Care UnitsInterventionIntervention StudiesIntratracheal IntubationIntubationInvestigationKnowledgeLaryngoscopyLifeLungMasksMethodologyMethodsMulticenter StudiesNational Institute of Child Health and Human DevelopmentNeonatalNeonatal Intensive Care UnitsNeurodevelopmental ImpairmentNoseOperating RoomsOutcomeOxygenPatientsPediatricsPennsylvaniaPerformancePhasePhysiologyPopulationPremedicationProceduresProcessProcess AssessmentProtocols documentationPublishingPulse OximetryRandomizedRandomized, Controlled TrialsRecommendationRegimenRegistriesResearchRiskRunningSafetySecondary toSiteTimeTitrationsTraumaUniversitiesVideo Recordingadverse outcomearmclinical practicedesignexperiencegroup interventionhigh riskimprovedmedication administrationneonatal morbiditynovelpediatric patientsperformance sitepreventprimary outcomeprospectiverandomized trialrespiratoryroutine providersafety outcomessecondary outcomesuccesssupplemental oxygentooltreatment armventilation
中文摘要
对于危重婴儿来说,气管插管(TI)是一种常见的、救命的、高风险的手术。
在NICU环境下进行的气管插管中,18%会发生不良事件,几乎一半
(48%)新生儿重症监护病房插管并发严重的氧减饱和(≥下降20%
脉搏血氧饱和度[SpO2])。严重的去饱和度现在被认为是一个重要的
导致新生儿发病率和神经发育结果受损的因素。虽然可以修改
已经确定了预防不良气管插管相关事件的因素,有以下几种
持续预防插管期间严重氧减饱和的有限干预措施
NICU患者。
在NICU环境下插管期间的典型做法是在
喉镜检查和气管插管尝试。患者在此期间经常出现呼吸暂停,因为
给药前给药,这是美国科学院推荐的一种做法
儿科。呼吸暂停氧合是一种通过鼻腔提供自由流动氧气的策略。
喉镜检查和气管插管时的插管。窒息氧合已被证明
成人和年龄较大的儿童在插管期间防止或推迟氧气减饱和。到目前为止,没有
已发表的研究已系统地评估了气管插管期间呼吸暂停氧合的影响。
适用于NICU环境中的婴儿。在这个R21应用中,我们提出了一项试点随机试验
在新生儿重症监护室接受气管插管的28周校正胎龄的婴儿≥
设置以确定是否有呼吸暂停氧合,而不是呼吸支持或氧气
尝试喉镜和气管插管,减少血氧饱和度下降的幅度
在气管插管期间。
英文摘要
Tracheal Intubation (TI) is a common, life-saving, high-risk procedure for critically ill infants.
Adverse events occur in 18% of tracheal intubations performed in the NICU setting, and almost half
(48%) of NICU intubations are complicated by severe oxygen desaturation (≥20% decline in
pulse oximetry saturation [SpO2]). Severe desaturation is now recognized as an important
contributor to neonatal morbidity and impaired neurodevelopmental outcomes. While modifiable
factors have been identified that prevent adverse tracheal intubation associated events, there are
limited interventions that consistently prevent severe oxygen desaturation during intubation in
NICU patients.
Typical practice during intubation in the NICU setting is to remove respiratory support during
laryngoscopy and tracheal intubation attempts. Patients are often apneic during this period due
to pre-medication administration, a practice that is recommended by the American Academy of
Pediatrics. Apneic oxygenation is a strategy in which free flowing oxygen is provided via nasal
cannula during laryngoscopy and tracheal intubation. Apneic oxygenation has been demonstrated to
prevent or delay oxygen desaturation during intubation in adults and older children. To date, no
published studies have systematically assessed the impact of apneic oxygenation during intubation
for infants in the NICU setting. In this R21 application we propose a pilot randomized trial of
infants ≥28 weeks corrected gestational age who undergo tracheal intubation in the NICU
setting to determine if apneic oxygenation, compared with no respiratory support or oxygen during
laryngoscopy and tracheal intubation attempt, reduces the magnitude of decline in oxygen saturation
during tracheal intubation.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Understanding organizational culture and implementation of evidence-based resuscitation practices
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批准号:10591266
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项目类别:
-
资助金额:$8.9万
-
财政年份:2023
-
负责人:Elizabeth Foglia
-
依托单位:
Video repositories for clinical research: Overcoming barriers and testing utility
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批准号:10674051
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项目类别:
-
资助金额:$19.7万
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财政年份:2022
-
负责人:Elizabeth Foglia
-
依托单位:
Video repositories for clinical research: Overcoming barriers and testing utility
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批准号:10523823
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项目类别:
-
资助金额:$24.96万
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财政年份:2022
-
负责人:Elizabeth Foglia
-
依托单位:
Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU
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批准号:10373276
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项目类别:
-
资助金额:$27.04万
-
财政年份:2022
-
负责人:Elizabeth Foglia
-
依托单位:
Optimizing Tracheal Intubation Outcomes and Neonatal Safety (OPTION SAFE)
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批准号:10518807
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项目类别:
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资助金额:$72.9万
-
财政年份:2022
-
负责人:Elizabeth Foglia
-
依托单位:
Respiratory function monitoring during resuscitation of extremely preterm infants: An ancillary study to the SAIL trial
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批准号:9181219
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项目类别:
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资助金额:$8.54万
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财政年份:2016
-
负责人:Elizabeth Foglia
-
依托单位:
Respiratory function monitoring during resuscitation of extremely preterm infants: An ancillary study to the SAIL trial
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批准号:9346640
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项目类别:
-
资助金额:$8.54万
-
财政年份:2016
-
负责人:Elizabeth Foglia
-
依托单位: