权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Vestibular System Function Following Blast Exposure

爆炸暴露后的前庭系统功能

基本信息

批准号：
10570841
负责人：
J David Dickman
金额：
$ 42.54万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10570841
关键词：
Address Affect Age Air Pressure Anatomy Animals Automobile Driving Bass Behavior Behavioral Blast Injuries Brain Stem Cells Clinical Cochlea Devices Discrimination Disease Disorientation Dizziness Equilibrium Etiology Exhibits Exposure to Eye Movements Functional disorder Hair Cells Head Human Injury Laboratories Measures Military Personnel Modernization Morphology Motion Mus Nature Neurons Neurosciences Partner in relationship Patient Self-Report Patients Persons Physiological Physiology Property Public Domains Questionnaires Recovery Reporting Reproducibility of Results Research Rodent Science Semicircular canal structure Shock Societies Source Structure Symptoms System Testing Time Trauma Traumatic Brain Injury Tube Vestibular nucleus structure Visual behavioral response behavioral study blast exposure common symptom equilibration disorder experience experimental study functional loss gaze insight mouse model neural neural correlate operation otoconia pressure receptor response spiral ganglion vestibulo-ocular reflex

项目摘要

PROJECT SUMMARY Blast exposures are unfortunately becoming a common experience in the military and public domains. Balance disorders, including dizziness, visual instability, and spatial disorientation are among the most common symptoms reported in blast injury patients. Although the etiology is unknown, it is possible that damage to the vestibular receptors and their innervating afferents has occurred, even with low blast intensity levels. We have developed a whole body blast generator (shock tube) for rodent use that delivers a pressure waveform which mimics that produced by improvised explosive devices (IED). We will capitalize on our unique expertise in vestibular research to perform a combination of anatomical, physiological, and behavioral studies to gain insight into how the vestibular system is affected by blast exposure and leads to vestibular dysfunction. In Aim 1, we will examine the anatomical structure of the semicircular canal and otolith receptors in C57/Bl6 mice, as well as their innervating afferents, in groups of animals receiving different intensities of a single blast wave exposure at multiple post-blast survival days and compare them to same age litter-mate controls with no blast exposure. In Aim 2, we will examine the dynamic response properties of canal and otolith afferents to motion stimulation following blast exposure. In Aim 3, we will examine the response vestibuloocular reflex (VOR) and its neural correlates in the vestibular nuclei in animals exposed to the same blast conditions and compare them to non-blast litter mate controls. Together, these experiments seek to understand how blast exposure affects vestibular system structure and function so that more effective protective measures and treatment options can be developed for blast exposure patients.

项目总结