Core D: Biostatistics Core

核心 D：生物统计学核心

• 批准号: 10573313
• 负责人: Mary E. Putt
• 金额: $ 12.3万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573313
• 关键词: Address; Animals; Biometry; Biostatistics Core; COVID-19 pandemic; Canis familiaris; Carbon; Clinical; Clinical Trials; Code; Collaborations; Consult; Data Analyses; Data Storage and Retrieval; Dose; Dose Rate; Electrons; Ensure; Grant; Graph; Growth; Institution; Knowledge; Malignant - descriptor; Manuscripts; Mission; Modality; Normal tissue morphology; Phase; Population; Preparation; Program Research Project Grants; Protocols documentation; Protons; Public Health; Qualifying; Radiation Dose Unit; Radiation Oncology; Radiation therapy; Reproducibility; Reproducibility of Results; Research; Research Design; Research Personnel; Research Project Grants; Sample Size; Secure; Statistical Data Interpretation; System; Testing; Time; United States National Institutes of Health; Work; analytical tool; anticancer research; cloud based; data sharing; design; experience; experimental study; innovation; interest; particle; pre-clinical; pre-clinical research; programs; skills; tool; translational study; tumor growth

Summary Core D aims to provide state of the art support for the biostatistics needs of the pre-clinical experiments proposed in the P01 Grant. Core D will work with project investigators to create innovative feasible designs for the dose- finding studies in canine clinical trials, and to create efficient study designs for the mechanistic animal studies. We will execute efficient and robust statistical analyses, and work with the investigators to effectively present their results for presentation. All of the analyses will be carried out using workflows and well-documented code, thus ensuring the highest possible level of reproducibility for the findings relevant to the scientific questions of interest. Secure cloud-based data storage systems will be used to share data, documents, protocols, and analyses across all Projects and Cores, providing for real time coordination and review of experimental progress and analyses. These tools have proven extremely valuable during the COVID-19 pandemic and will continue to be used, assuring seamless collaboration with investigators situated in other institutions.

概括 核心D旨在为提出的临床前实验的生物统计学需求提供最新支持的状态 在P01赠款中。核心D将与项目调查人员合作，为剂量创建创新的可行设计 - 在犬临床试验中找到研究，并为机械动物研究创建有效的研究设计。 我们将执行高效且强大的统计分析，并与研究人员合作以有效地呈现 他们的演示结果。所有分析将使用工作流和有据可查的代码进行， 从而确保与与科学问题相关的发现的最高可重复性水平 兴趣。安全的基于云的数据存储系统将用于共享数据，文档，协议和 在所有项目和核心上进行分析，提供实时协调和审查实验进度 和分析。这些工具在COVID-19大流行期间已被证明非常有价值，并将继续 可以使用，确保与其他机构中的调查员无缝合作。