Core D: Biostatistics Core

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Summary Core D aims to provide state of the art support for the biostatistics needs of the pre-clinical experiments proposed in the P01 Grant. Core D will work with project investigators to create innovative feasible designs for the dose- finding studies in canine clinical trials, and to create efficient study designs for the mechanistic animal studies. We will execute efficient and robust statistical analyses, and work with the investigators to effectively present their results for presentation. All of the analyses will be carried out using workflows and well-documented code, thus ensuring the highest possible level of reproducibility for the findings relevant to the scientific questions of interest. Secure cloud-based data storage systems will be used to share data, documents, protocols, and analyses across all Projects and Cores, providing for real time coordination and review of experimental progress and analyses. These tools have proven extremely valuable during the COVID-19 pandemic and will continue to be used, assuring seamless collaboration with investigators situated in other institutions.