Biostatistics & Data Science Core

(核心C-BDSC：生物统计与数据科学核心) 项目总结 描述：生物统计与数据科学核心(BDSC)提供全面和专业的分析工具 对于希望在定量实验设计、生物统计学和信息学技术方面获得支持的IDDRC用户 特别强调机器学习。核心在以下两个领域拥有实质性的专门知识 分核心(1)生物统计学，由生物统计、流行病学和信息学系的教员在 宾夕法尼亚大学(宾夕法尼亚大学)支持基础科学、临床试验和 观察性研究和随后数据的分析(2)信息学和机器学习，有教员 来自费城儿童医院(CHOP)生物医学健康信息学系，提供 支持高级别的数据集成，包括解释、分类和预测 模特儿。第三个分核心将支持职业发展和教育。核心成员承诺 导师和老师。玛丽·普特博士，生物统计学教授，前研究生副主任 流行病学和生物统计学小组和生物统计学研究生项目主席，是总体 核心主任和生物统计分核心主任。生物医学副教授王凯博士 CHOP和病理学(宾夕法尼亚大学)的健康信息学和生物医学研究所的高级研究员 信息学是信息学和机器学习分核心的副主任。副会长萧睿博士 生物统计学和儿科学教授，职业发展和教育小组副主任- 堆芯 与IDDRC任务的相关性：BDSC支持我们IDDRC的总体主题，特别是(1)有影响力 智力和发育障碍(IDD)相关疾病的病因和治疗研究 (2)新一代碘缺乏病研究人员的职业发展和教育。BDSC是从 以前的生物统计学和生物信息学核心；它与其他国际发展研究中心的活动互动和/或补充 核心以及研究项目。生物统计学系(帕特博士和肖博士)来自这个久负盛名的 CORE与同事、信息学和机器学习专家王凯博士联手成立了 新的生物统计和数据科学核心。生物统计学系通过与IDDRC的长期合作，是 融入IDD生物医学研究的多个领域，从基础科学到临床和翻译 医药。王博士通过他在机器学习和其他信息学方法方面的专业知识，最近 与IDDRC成员建立了合作关系，并在脑部疾病方面拥有丰富的经验，增加了一个新的和 新一代大数据分析和培训的激动人心的角度。 资格：这些服务适用于#年儿童医院经批准的IDDRC用户 费城/宾夕法尼亚大学(CHOP/Penn)和整个IDDRC网络中心的用户。

(CORE C- BDSC: BIOSTATISTICS & DATA SCIENCE CORE) PROJECT SUMMARY Description: The Biostatistics & Data Science Core (BDSC) provides comprehensive and expert analytic tools for IDDRC users desiring support in quantitative experimental design, biostatistics, and informatics techniques with particular emphasis on machine learning. The Core has substantive expertise in areas represented by two sub-cores (1) Biostatistics, with faculty from the Department of Biostatistics, Epidemiology & Informatics at the University of Pennsylvania (PENN) supporting experimental design of basic science, clinical trials and observational studies and the analysis of the ensuing data (2) Informatics and machine learning, with faculty from the Department of Biomedical Health Informatics at Children’s Hospital of Philadelphia (CHOP), providing support for high-level data integration of ‘omics’ data along with interpretation, classification and predictive modelling. A third sub-core will support Career Development and Education. Core members are committed mentors and teachers. Dr. Mary Putt, Professor of Biostatistics and former Associate Vice-Chair of the Graduate Group in Epidemiology & Biostatistics and Program Chair of the Biostatistics graduate program, is the overall Core Director and Director of the Biostatistics Sub-Core. Dr. Kai Wang, Associate Professor of Biomedical Health Informatics at CHOP and Pathology (PENN) and, and Senior Fellow of the Institute for Biomedical Informatics, is Associate Director of the Informatics & Machine Learning Sub-Core. Dr. Rui Xiao, Associate Professor of Biostatistics, and Pediatrics, is Associate Director of the Career Development & Education Sub- Core Relevance to IDDRC Mission: The BDSC supports the overall themes of our IDDRC, specifically (1) impactful research into the cause and treatment of conditions related to intellectual and developmental disability (IDD) and (2) career development and education of a new generation of IDD researchers. The BDSC evolved out of the previous Biostatistics & Bioinformatics core; it interacts with and/or complements the activities of the other IDDRC Cores as well as the Research Project. The Biostatistics faculty (Drs. Putt and Xiao) from this well-established core have joined forces with colleague, Dr. Kai Wang, expert in Informatics and Machine Learning to form the new Biostatistics & Data Science core. The Biostatistics faculty, through long association with the IDDRC, are integrated into multiple domains of IDD biomedical research, from basic science to clinical and translational medicine. Dr. Wang, through his expertise in machine learning and other informatics approaches, his recently established collaborations with IDDRC members and extensive experience in brain disorders, adds a new and exciting angle to the new generation of big data analytics and training. Eligibility: These services are available both to approved users of the IDDRC at Children’s Hospital of Philadelphia/University of Pennsylvania (CHOP/PENN) and to users at Centers throughout the IDDRC Network.