A Synchrotron Radiation Structural Biology Resource
同步辐射结构生物学资源
基本信息
- 批准号:10578809
- 负责人:
- 金额:$ 38.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:BiologicalBiomedical ResearchClinicCollaborationsCommunitiesComplexComputer softwareCryoelectron MicroscopyCrystallographyDataData AnalysesDedicationsDetectionEducation and OutreachEducational workshopElectronicsExperimental DesignsFosteringGenerationsGoalsHybridsImageIn SituIndividualInternationalInvestmentsLengthLibrariesLigand BindingLightMeasurementMedical ImagingMethodsModificationMolecular BiologyOpticsPeer ReviewPerformancePhaseProcessResearchResolutionResourcesRoentgen RaysSamplingScheduleSchoolsScienceScientistServicesSiteSourceSpectrum AnalysisSynchrotronsSystemTechniquesTechnologyTemperatureTimeTrainingTraining ProgramsUnited StatesX ray spectroscopyabsorptionbiological systemsdesigndetectorexperienceexperimental studyfuture implementationimaging facilitiesimaging programimprovedinnovationinnovative technologiesinstrumentationmillisecondmultimodalityonline resourceoperationoutreachoutreach programspectroscopic imagingstructural biologystructural imagingsubmicronsuccesssynchrotron radiationtheoriestoolweb portal
项目摘要
Synchrotron radiation (SR) is an extremely bright and tunable x-ray source that enables forefront
research in structural molecular biology (SMB). The goal of “A Synchrotron Structural Biology
Resource" at the Stanford Synchrotron Radiation Lightsource (SSRL) is to provide users access
to an integrated, mature SMB Resource with state-of-the-are synchrotron beam line facilities for
macromolecular crystallography, x-ray absorption/emission/imaging spectroscopy and small
angle x-ray scattering/diffraction, that form the three Resource Technical Operations Cores.
Special emphasis is to create streamlined user access, provide dedicated user support and
services, to train users, and to perform outreach on the scientific benefits of the capabilities of
these specialized, yet mature facilities to the biomedical research community. Multiple innovative
access mechanisms will be provided, that will include both single- and multiple-technique
approaches to access the Cores, based on a transparent and robust external peer-review
process. A multifaceted training and outreach program will include individual training, workshops,
summer schools, on-the-road, and support clinic segments by experienced science and technical
staff. A Resource web portal will provide streamlined scientific, technical, training, outreach and
administrative material and other relevant information. A principal aim is to optimize and maintain,
for reliable and forefront performance, experimental facilities and instrumentation, detectors,
software and computing and network capabilities on the SMB Resource’s 8+ beam lines at SSRL,
capitalizing on the high SR x-ray performance of SSRL’s 3rd generation storage ring SPEAR3,
and at the MFX station at LCLS. A multi-facility proposal mechanism will facilitate access to
complementary Cryo-EM and LCLS stations on-site at SLAC. With a specialized focus on user
training, support and service, the SMB Resource will enable the scientific success for challenging
and routine projects in the biomedical sciences.
同步辐射(SR)是一种非常明亮和可调的x射线源,使前线
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BRITT HEDMAN其他文献
BRITT HEDMAN的其他文献
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{{ truncateString('BRITT HEDMAN', 18)}}的其他基金
A Synchrotron Radiation Structural Biology Resource
同步辐射结构生物学资源
- 批准号:
10350698 - 财政年份:2020
- 资助金额:
$ 38.97万 - 项目类别:
SINGLE CRYSTAL XAS STUDIES ON O2 ACTIVATING HEME PROTEINS
O2 激活血红素蛋白的单晶 XAS 研究
- 批准号:
8362248 - 财政年份:2011
- 资助金额:
$ 38.97万 - 项目类别:
S K-EDGE XAS STUDIES AS A PROBE OF ELECTRONIC STRUCTURE/CONTRIBUTION TO FUNCTION
SK-EDGE XAS 研究作为电子结构/功能贡献的探针
- 批准号:
8362398 - 财政年份:2011
- 资助金额:
$ 38.97万 - 项目类别:
XAS COMPARISON OF NITROGENASE MOFE PROTEIN MUTANTS
固氮酶 MOFE 蛋白突变体的 XAS 比较
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8362047 - 财政年份:2011
- 资助金额:
$ 38.97万 - 项目类别:
INVESTIGATION OF ELECTRONIC STRUCTURES OF FE-S AND MO-S ACTIVE SITES AND THEIR R
FE-S和Mo-S活性位点的电子结构及其R的研究
- 批准号:
8362082 - 财政年份:2011
- 资助金额:
$ 38.97万 - 项目类别:
100-ELEMENT GE DETECTOR SYSTEM FOR X-RAY ABSORPTION SPECTROSCOPY
用于 X 射线吸收光谱的 100 元件 GE 探测器系统
- 批准号:
8362139 - 财政年份:2011
- 资助金额:
$ 38.97万 - 项目类别:
100-ELEMENT GE DETECTOR SYSTEM FOR X-RAY ABSORPTION SPECTROSCOPY
用于 X 射线吸收光谱的 100 元件 GE 探测器系统
- 批准号:
8170071 - 财政年份:2010
- 资助金额:
$ 38.97万 - 项目类别:
INVESTIGATION OF ELECTRONIC STRUCTURES OF FE-S AND MO-S ACTIVE SITES AND THEIR R
FE-S和Mo-S活性位点的电子结构及其R的研究
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8169978 - 财政年份:2010
- 资助金额:
$ 38.97万 - 项目类别:
SINGLE CRYSTAL XAS STUDIES OF NITROGENASE PROTEINS
固氮酶蛋白的单晶 XAS 研究
- 批准号:
8169950 - 财政年份:2010
- 资助金额:
$ 38.97万 - 项目类别:
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