A Synchrotron Radiation Structural Biology Resource

同步辐射结构生物学资源

• 批准号: 10578809
• 负责人: BRITT HEDMAN
• 金额: $ 38.97万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10578809
• 关键词: Biological; Biomedical Research; Clinic; Collaborations; Communities; Complex; Computer software; Cryoelectron Microscopy; Crystallography; Data; Data Analyses; Dedications; Detection; Education and Outreach; Educational workshop; Electronics; Experimental Designs; Fostering; Generations; Goals; Hybrids; Image; In Situ; Individual; International; Investments; Length; Libraries; Ligand Binding; Light; Measurement; Medical Imaging; Methods; Modification; Molecular Biology; Optics; Peer Review; Performance; Phase; Process; Research; Resolution; Resources; Roentgen Rays; Sampling; Schedule; Schools; Science; Scientist; Services; Site; Source; Spectrum Analysis; Synchrotrons; System; Techniques; Technology; Temperature; Time; Training; Training Programs; United States; X ray spectroscopy; absorption; biological systems; design; detector; experience; experimental study; future implementation; imaging facilities; imaging program; improved; innovation; innovative technologies; instrumentation; millisecond; multimodality; online resource; operation; outreach; outreach program; spectroscopic imaging; structural biology; structural imaging; submicron; success; synchrotron radiation; theories; tool; web portal

Synchrotron radiation (SR) is an extremely bright and tunable x-ray source that enables forefront research in structural molecular biology (SMB). The goal of “A Synchrotron Structural Biology Resource" at the Stanford Synchrotron Radiation Lightsource (SSRL) is to provide users access to an integrated, mature SMB Resource with state-of-the-are synchrotron beam line facilities for macromolecular crystallography, x-ray absorption/emission/imaging spectroscopy and small angle x-ray scattering/diffraction, that form the three Resource Technical Operations Cores. Special emphasis is to create streamlined user access, provide dedicated user support and services, to train users, and to perform outreach on the scientific benefits of the capabilities of these specialized, yet mature facilities to the biomedical research community. Multiple innovative access mechanisms will be provided, that will include both single- and multiple-technique approaches to access the Cores, based on a transparent and robust external peer-review process. A multifaceted training and outreach program will include individual training, workshops, summer schools, on-the-road, and support clinic segments by experienced science and technical staff. A Resource web portal will provide streamlined scientific, technical, training, outreach and administrative material and other relevant information. A principal aim is to optimize and maintain, for reliable and forefront performance, experimental facilities and instrumentation, detectors, software and computing and network capabilities on the SMB Resource’s 8+ beam lines at SSRL, capitalizing on the high SR x-ray performance of SSRL’s 3rd generation storage ring SPEAR3, and at the MFX station at LCLS. A multi-facility proposal mechanism will facilitate access to complementary Cryo-EM and LCLS stations on-site at SLAC. With a specialized focus on user training, support and service, the SMB Resource will enable the scientific success for challenging and routine projects in the biomedical sciences.

同步辐射(SR)是一种非常明亮和可调的X射线源，它使最前沿 结构分子生物学(SMB)研究。《同步加速器结构生物学》的目标 斯坦福大学同步加速器辐射光源(SSRL)的“资源”是为用户提供访问 到具有先进的同步加速器束线设施的集成、成熟的SMB资源 大分子结晶学、X射线吸收/发射/成像光谱和小分子 角X射线散射/衍射，这构成了三个资源技术操作核心。 特别强调的是创建简化的用户访问，提供专门的用户支持和 服务，培训用户，并就以下能力的科学惠益进行宣传 这些专门的，但成熟的设施，以生物医学研究社区。多重创新 将提供访问机制，包括单一技术和多种技术 以透明和有力的外部同行审查为基础的获取核心的方法 进程。一个多方面的培训和推广计划将包括个人培训、研讨会、 暑期学校，在路上，并由经验丰富的科学和技术人员支持诊所部分 工作人员。一个资源门户网站将提供精简的科学、技术、培训、外联和 行政资料和其他相关信息。一个主要目标是优化和维护， 为获得可靠和前沿的性能，实验设施和仪器、探测器、 SSRL的SMB资源的8+波束线路上的软件、计算和网络能力， 利用SSRL的第三代存储环SPEAR3的高SR x射线性能， 在LCLS的MFX车站。多设施建议机制将便利获得 SLAC现场配套的Cryo-EM和LCLS站点。以用户为重点 培训、支持和服务，中小企业资源将使挑战的科学成功 以及生物医学科学中的常规项目。