Administrative Core

行政核心

• 批准号: 10577764
• 负责人: JUN YAN
• 金额: $ 68.6万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577764
• 关键词: Acceleration; Adoptive Cell Transfers; Advisory Committees; Applications Grants; Area; Award; Bacterial Infections; Basic Science; Bioinformatics; Biometry; Cancer Biology; Cancer Center; Cancer Patient; Centers of Research Excellence; Clinical; Clinical Research; Collaborations; Coupled; Credentialing; Decision Making; Education; Ensure; Evaluation; Feasibility Studies; Feedback; Feeling hopeless; Funding; Goals; Grant; Human; Human Resources; Immune checkpoint inhibitor; Immune mediated destruction; Immune response; Immune system; Immunology; Immunotherapeutic agent; Individual; Interdisciplinary Study; International; Leadership; Learning; Malignant Neoplasms; Mentors; Mentorship; Molecular; Molecular Profiling; Nobel Prize; Oncolytic viruses; Participant; Patients; Physicians; Pilot Projects; Prediction of Response to Therapy; Procedures; Productivity; Qualifying; Research; Research Personnel; Resistance; Role; Scientist; Specimen; Strategic Planning; Study Section; Testing; Training Programs; Translational Research; Treatment outcome; Tumor Escape; United States National Institutes of Health; Universities; Writing; cancer immunotherapeutics; cancer immunotherapy; career; diversity and inclusion; experience; improved; innovation; interest; meetings; member; multidisciplinary; neoplastic cell; next generation; novel; operation; programs; response; senior faculty; success; translational study; tumor; tumor immunology

The goal of the CCII COBRE is to establish a thematic multidisciplinary research center of excellence at the University of Louisville that focuses on improving our understanding of cancer immunology and developing novel immunotherapeutic approaches. Importantly, with the recent clinical successes of immune checkpoint inhibitors and oncolytic viruses, there is great interest and momentum in understanding the interaction between the host immune system and neoplastic cells. Our projects proposing basic immunology research coupled with translational and human specimen studies are expected to ultimately lead to entirely new immunotherapeutic approaches, as well as strategies for overcoming resistance to existing agents. The Administrative Core (AC) will coordinate the professional activities of the more than 40 individuals who will constitute the new Center for Cancer Immunology and Immunotherapy (CCII). The AC will provide administrative, fiscal, and scientific oversight and planning for junior investigators, mentors, projects, the research core, a pilot program, and advisory committees. In addition to governance functions, the AC will provide key research and mentoring support. This will include the awarding of project grants, assignment of mentors, provision of a grant writing mentorship program, biostatistics and bioinformatics support, compliance and regulatory oversight, mentoring of pilot projects, and encouragement of diversity and inclusion. Internal advisors and an External Advisory Committee (EAC) that consists of five leading scientists in the CCII thematic area will guide the AC. The EAC will provide scientific guidance and constructive feedback regarding center/project progress and be involved in CCII strategic planning and in the selection of replacement and pilot projects. The two PIs of the overall CCII program will direct the AC with key support from two co-Is who have extensive experience administering multi- component grant programs and from two additional co-Is who are well qualified to oversee the essential biostatistics and bioinformatics support. Their efforts will supplement a mentoring program that is anchored by eight senior investigators who are experienced mentors and have been highly productive and well funded in the thematic area. The three specific aims of this Administrative Core that encompass all of these functions are to: (1) Establish procedures for CCII administration, planning, and decision-making; (2) Provide a mentorship program to accelerate the careers of the CCII junior investigators; and (3) Create a CCII pilot grant program that will stimulate new projects and collaborations. Innovative features of the AC are built on lessons learned from establishing other multidisciplinary thematic centers and include a shared governance approach that aims to ensure engagement of all participants and a holistic mentoring strategy that provides comprehensive guidance for our CCII junior investigators. By the end of the 5-year funding program, we expect that 4-6 CCII junior investigators will have been awarded R01 grants and that many of these graduates will remain key members of this new COBRE focused on cancer immunology and immunotherapy.

CCII COBRE的目标是建立一个卓越的主题多学科研究中心， 路易斯维尔大学，专注于提高我们对癌症免疫学的理解， 新的免疫学方法。重要的是，随着免疫检查点最近的临床成功， 抑制剂和溶瘤病毒，有很大的兴趣和动力，在了解之间的相互作用 宿主免疫系统和肿瘤细胞。我们的项目提出基础免疫学研究，以及 翻译和人类标本研究有望最终导致全新的免疫学 方法，以及克服现有药剂耐药性的战略。行政核心（AC） 将协调40多个人的专业活动，他们将组成新的中心， 癌症免疫学和免疫治疗（CCII）。AC将提供行政，财政和科学 监督和规划初级研究人员，导师，项目，研究核心，试点计划， 咨询委员会。除了治理职能外，咨询委员会还将提供关键的研究和指导 支持.这将包括项目赠款的授予，导师的分配，提供赠款写作， 导师计划，生物统计学和生物信息学支持，合规和监管监督，指导 试点项目，并鼓励多样性和包容性。内部顾问和外部顾问 由CCII专题领域的五位主要科学家组成的EAC委员会将指导AC。选管会 将提供有关中心/项目进展的科学指导和建设性反馈，并参与 CCII的战略规划以及在替换和试点项目的选择。整体CCII的两个PI 该计划将指导AC的关键支持，从两个共同的是谁拥有丰富的经验，管理多， 组成部分赠款计划，并从两个额外的共同是谁是很有资格监督的基本 生物统计学和生物信息学支持。他们的努力将补充一个指导计划， 八名资深调查员，他们是经验丰富的导师，在以下方面富有成效和资金充足： 专题领域。这一行政核心涵盖所有这些职能的三个具体目标是： 目的是：（1）建立CCII管理、规划和决策程序;（2）提供指导 加速CCII初级研究人员职业生涯的计划;（3）创建CCII试点补助金计划 这将刺激新的项目和合作。AC的创新功能是建立在经验教训的基础上的 建立其他多学科专题中心，并包括一个共同的治理方法， 确保所有参与者的参与和全面的指导战略， 为我们的CCII初级调查员提供指导。到5年资助计划结束时，我们预计将有4-6个CCII 初级研究人员将获得R 01赠款，这些毕业生中的许多人将继续发挥关键作用， 这个新的COBRE成员专注于癌症免疫学和免疫疗法。